Monovisc Vs. Synvisc: Similarities And Differences Explained

Monovisc and Synvisc article image

Osteoarthritis is a progressive and debilitating disease of the synovial joint. It occurs when the protective articular cartilage, which sheathes the ends of bones within a synovial joint, breaks down due to years of wear and tear or injuries. As the cartilage deteriorates, the lubricating synovial fluid decreases in quantity, which results in painful friction between the bones.

Patients will then experience symptoms like pain, stiffness, tenderness, loss of flexibility, reduced mobility, and even bone spurs. While there is no cure for this chronic disease, patients can manage their condition via a combination of pharmacological approaches, such as oral analgesic agents and non-steroidal anti-inflammatory drugs, and non-pharmacological approaches, such as a healthy lifestyle, joint support gear, and physiotherapy.

Patients with advanced cases of OA may require second-line therapy, which involves the intraarticular injection of orthopedic implants, also known as viscosupplements. These are injectable gels that closely mimic the properties and actions of the natural synovial fluid and help to improve joint function. There are several brands of orthopedic injectables available for sale, with the most popular ones being Monovisc and Synvisc. These two products are similar in some aspects but also have several differences a medical professional should know before buying a viscosupplement online and using it to treat patients.

Similarities Between Monovisc And Synvisc

There might be a bit of confusion when you’re picking a viscosupplement to buy online, as Monovisc and Synvisc share the following similarities:

  • Active component. Both of these brands contain naturally occurring, cross-linked hyaluronic acid that is also found in the synovial fluid.
  • Mechanism of action. Both implants are designed to closely mimic the physiology and performance of synovial fluid. These implants not only lubricate the space between the bones but also help absorb shock during sudden impact, allowing the joints to move smoothly with minimal pain and discomfort.
  • Injection technique. Since Monovisc and Synvisc are orthopedic implants, they are injected into the articular space between the bones via intraarticular injection.
  • Possible side effects. Following treatment, patients will potentially experience localized inflammatory reactions, such as pain and swelling. These reactions typically happen due to the minimally invasive needle pricks. Patients may also experience fluid buildup around the joints that have been injected with the viscosupplement.
  • Contraindications. Both Monovisc and Synvisc are contraindicated in pregnant, breastfeeding, and pediatric patients. Clients whose joints are highly inflamed or even infected are also contraindicated. Failure to comply with the warning might result in the worsening of osteoarthritis symptoms.

Differences Between Monovisc and Synvisc

Despite their similarities, Monovisc and Synvisc can be differentiated on the basis of certain features, which include the following:

  • Origin of hyaluronic acid. The sodium hyaluronate (hyaluronic acid) in Monovisc is harvested from rooster combs. The final product contains 22mg/ml of cross-linked sodium hyaluronate that is presented in a 4ml syringe (88 mg/4ml). Because of its animal origin, Monovisc is not suitable for patients who are allergic to avian proteins. Synvisc contains hyaluronic acid that is manufactured via bacterial fermentation. The final product is composed of 8mg/ml cross-linked hyaluronic acid that is supplied in a 2 mL syringe (16 mg/2 mL).
  • Formulation. Although both brands function similarly, they have vastly different properties. Monovisc is formulated to have an average molecular weight of 1 to 2.9 million Daltons, while Synvisc is designed to have an average molecular weight of 6 million Daltons, which more closely resembles the synovial fluid in a healthy, young adult.
  • The number of injections. As the name suggests, Monovisc is a single-dose treatment that is injected into the affected joint one time. The results last for approximately six months. Synvisc is administered weekly for three weeks to provide the same results. Synvisc offers a single-injection version as well.
  • Versatility. Monovisc is mainly used to correct knee joints that are affected by osteoarthritis (OA), while Synvisc is a versatile implant that can correct many synovial joints, including the knees, hips, ankles, and shoulders. The dosage differs according to the area of treatment.
  • Cost of treatment. Patients who undergo Monovisc treatment can expect to pay approximately $1347.77, while Synvisc treatment costs approximately $1073.90.

Monovisc Vs. Synvisc — Which One To Choose

If you don’t know which viscosupplement to choose, you should know that both Monovisc and Synvisc have been proved to be safe and efficient against the symptoms of osteoarthritis. If you’re looking for effective and versatile treatment for your patients, Synvisc might be a better option, as it can be used for different types of joints. If knee joints are your main focus, consider getting Monovisc — having just one injection instead of 3-4 is highly valued by patients. Both brands of orthopedic injectables are available to buy online at DoctorMedica at a low price.


Note on articles: These articles are not endorsed by DoctorMedica nor reviewed for medical accuracy. Similarly, views and opinions expressed are those of the author only. Articles are meant for informational purposes only. Ask your doctor for professional medical advice.