Orthovisc Vs Supartz – Which One Is Best?

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Osteoarthritis (OA) is a progressive inflammatory disease of the synovial joints that results from cartilage degeneration.

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What is osteoarthritis (OA)?

Osteoarthritis (OA) is a progressive inflammatory disease of the synovial joints that results from cartilage degeneration. A synovial joint comprises two bones that are covered with strong articular cartilage. This protective membrane continuously secretes lubricating synovial fluid via a process known as weeping lubrication. This fluid ensures that the joints move smoothly without any painful friction between the bones. However, inevitable wear-and-tear combined with risk factors like excessive weight, genetics, and previous injuries cause the articular cartilage to break down. The bones will then painfully grind together and symptoms like reduced joint flexibility, tenderness, and stiffness will manifest.

Following OA diagnosis, most patients are advised by their physicians to undergo a combination of non-pharmacological (e.g. assistive devices, physical therapy, weight reduction if necessary, etc.) and pharmacological (e.g. analgesic agents, non-steroidal anti-inflammatory drugs, etc.) treatment modalities. However, this first line therapy may not always be successful at providing adequate relief to patients. Such patients are recommended to undergo second line therapy, which is viscosupplementation.

This medical procedure involves injecting the arthritic synovial joints with lubricating hyaluronic acid gel. Hyaluronic acid gel is a key component of the natural synovial fluid but is found in lower concentrations in osteoarthritic joints. Once the orthopedic implant had been administered into the affected joints, it will not only restore the usual joint function, but it may also help to postpone the need for corrective surgeries. The two most commonly used brands of viscosupplement are Orthovisc and Supartz.

What are the similarities between Orthovisc and Supartz?

Popular viscosupplementsOrthovisc and Supartz share some similar features:

Clinical Indication

These orthopedic gels are indicated for patients who had failed to respond adequately to simple pain relief medications and lifestyle modifications. Compared to other brands that can be used on a wide range of synovial joints, Orthovisc and Supartz are intended only to manage arthritic knee joints.

Active Ingredient

Both Orthovisc and Supartz contain highly purified hyaluronic acid gel that is free from potentially harmful pyrogens.

Mechanism of Action

Both brands are designed to mimic the biological action of the naturally occurring synovial fluid. Once the viscosupplement is injected into the articular space between the bones, the bones glide against each other smoothly. Painful symptoms of osteoarthritis are significantly reduced, and patients can enjoy a better quality of life.

Administration Technique

Both Orthovisc and Supartz must be administered into the synovial space between the bones. This intraarticular injection process can only be done by a certified and skilled healthcare professional once the affected joint has been assessed, cleaned, and disinfected. Any fluid effusion must be removed prior to implantation to reduce the risk of undesirable side effects.


Though these two brands are of high quality, they are contraindicated for use in some groups of patients due to an unestablished safety profile. These groups include expecting or breastfeeding patients, pediatric patients, patients who are affected by serious joint inflammation, and patients who have skin disorders affecting the proposed area of injection. Failure to comply to the warnings can result in health complications; hence, it is best that the patient’s medical history is extensively reviewed during the pre-procedural session.

Possible Side Effects

Following the viscosupplementation process, patients may develop some commonly reported inflammatory reactions such as swelling and pain. These side effects are generally contained within the injection area. Patients may also experience fluid buildup around the treated joints. Patients must obtain quick medical attention if their side effects worsen or persist.

What are the differences between Orthovisc and Supartz?

Despite their similarities, Orthovisc and Supartz differ from one another in a number of ways:  

Origin of Hyaluronic Acid

Although both viscosupplements contain hyaluronic acid, the molecules are extracted from different sources. The hyaluronic acid particles in Orthovisc are manufactured biotechnologically via a bacterial fermentation process. The injectable gel has a hyaluronic acid strength of 15mg/ml, which is supplied in a 2ml syringe. The hyaluronic acid molecules in Supartz are harvested ethically from rooster combs. The final product has a hyaluronic acid concentration of 10mg/ml and is packaged in a 2.5ml syringe. Patients who are allergic to avian proteins can be treated with Orthovisc to prevent any allergic attacks.


Besides the origin of the active ingredients, these intraarticular implants also have different molecular weights. Orthovisc has an average molecular weight of approximately 1 to 2.9 million Daltons whereas the average molecular weight of Supartz is approximately 0.62 to 1.17 million Daltons. These molecular weights are much lighter compared to that of natural synovial fluid found in healthy young adults, which has an average molecular weight of 6 million Daltons.

Number of Injections

For optimal outcome, Orthovisc is administered into the affected joint a total of three to four times, one week apart. As for Supartz, a complete treatment course requires five injections, also given on a weekly basis. Both injections relieve pain for approximately 6 months

Cost of Treatment

The estimated cost of treatment for Orthovisc and Supartz is $1,355.70 and $1,264.80, respectively, in the United States. 

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