Side Effects (Reactions)
- Injection-related reactions including bruising, erythema (redness), itching, swelling, pain, or tenderness at the injection site. These typically resolve within a few days after a skin injection or a week after lip injection.
- Papules or nodules.
- Induration (hardening).
- Rarely, abscess, acne, atrophy, scarring, blisters, dermatitis, discoloration, granuloma, hypersensitivity, infection, ischemia (blood supply restriction), necrosis (tissue death), mass, paresthesia (tingling) or other neurological symptoms, pruritus (itching), rash, herpes reactivation, short duration of effect, telangiectasia (spider veins), or urticaria.
- Vascular compromise from intravascular injection or compression, with blanching, discoloration, necrosis, or ulceration near injection site.
- Rarely, visual disturbance from intravascular injection.
- Rarely, ischemia or necrosis of the nose, especially in patients who have had rhinoplasty.
- Rarely, lumps in the dermis remaining for several months or longer than a year.
- Inflammation symptoms shortly after injection or two to four weeks later.
- Post-inflammatory pigment changes in people with dark skin, Fitzpatrick Type IV-VI.
If there is unexplained inflammation, exclude infections and treat if necessary, since infections that are not treated adequately could cause complications such as abscess. Do not treat with just oral corticosteroids, use concurrent antibiotic treatment. Carefully assess need for prolonged medication, such as corticosteroids or antibiotics, since this may carry a risk for the patient. If there is persistent or recurrent inflammation, you may need to use aspiration or drainage, extrusion, or hyaluronidase injections to remove. Before removal, you can reduce swelling by using NSAIDs for two to seven days or corticosteroids for less than seven days. If patient has a clinically-significant reaction, consider cause and significance before retreatment. These may not be all the possible side effects.