Manufacturer : Merz Pharmaceuticals

Active Substance(s) : Hyaluronic acid, mannitol

Strength : 23mg/ml

Pack Size : 2-1ml prefilled syringes

Accessories : Package insert, 4-27G 1/2" needles, 4 traceability labels


$139.00 / unit

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Quantity Our Price
1 - 5 pack(s) $139.00 USD
6 - 10 pack(s) $135.00 USD
11 - 20 pack(s) $132.00 USD
21+ pack(s) USD$130.00 130.00USD

ETERMIS 3 - 23 mg/ml - 2 x 1 ml


Main Benefits

  • Helps smooth the look of moderate wrinkles and augments lips.
  • Includes mannitol for its antioxidant properties.
  • Hyaluronic acid holds moisture to help restore volume to skin while stimulating collagen growth.
  • Monophasic, cohesive gel provides natural-looking and long-lasting results.


Hyaluronic acid 23 mg/ml, sodium phosphate buffer pH 7.1 q.w. for 1 g, and mannitol.

Ingredients Information

  • Hyaluronic acid: holds moisture within skin to restore volume and helps stimulate collagen growth for improved elasticity.
  • Mannitol: an antioxidant to help trap free radicals, reducing hyaluronic acid degradation.

Use Instructions

  1. Inform patient of product indications, contraindications, incompatibilities, and risk of potential side effects. Ensure patient is aware of signs and symptoms of potential side effects.
  2. Ensure filler is at room temperature.
  3. Inspect package for damage. If there is damage, do not use. Do not use after expiry date.
  4. Gently unscrew syringe cap.
  5. Screw needle onto luer lock connection, gently turning until needle is firmly in place. The included needles are recommended. If you choose to use a cannula instead, depending on injection technique and treated area, use one with an inner diameter at least as big as the included needles.
  6. Pull protective needle cap horizontally to remove.
  7. Thoroughly disinfect treatment area.
  8. Use linear threading, fanning, cross-hatching, serial puncture, or sandwich injection techniques to slowly inject filler into the mid to deep dermis in the desired area. Use about a 30 to 35 degree angle between the needle and skin. The quantity you inject depends on the area you are correcting. Do not inject more than 20 ml of reticulated hyaluronic acid per person per year.
  9. If needle becomes blocked, do not apply force to the syringe plunger. Instead, stop injecting and replace the needle.
  10. If patient experiences vision changes, signs of a stroke, skin blanching, or unusual pain, stop injecting immediately. Ensure patient receives prompt medical attention, and possibly ensure they are evaluated by an appropriate specialist if there is intravascular injection.
  11. After injection, massage the treated area to ensure the gel is evenly distributed.
  12. Properly dispose of any used or opened syringes and needles.


  • Not for use in patients using NSAIDs, antiplatelet agents, anticoagulants, immunomodulators, or similar drugs.
  • Not for use in patients with allergic diseases, autoimmune disease, sarcoid-like granulomatous disease, or subacute bacterial endocarditis.
  • Not for use in patients with inflammation or skin infection, such as acne.
  • Not for use in patients with a known hypersensitivity to products containing hyaluronic acid.
  • Not for use in patients who are prone to developing skin inflammation or with a tendency to form hypertrophic scars or keloids.
  • Not for use in pregnant women.
  • Not for use in breastfeeding women.
  • Not for use in children and adolescents.
  • Not for injection in the nose or glabellar area.
  • Not for injection into tendons, muscles, or bones.
  • Not for increasing breast volume.
  • Not for intravascular injection. Injection into blood vessels may cause embolization, vessel occlusion, ischemia, or infarction. Inject slowly and use least amount of pressure necessary, to minimize risk.
  • Do not overcorrect.
  • Not for injection into an area that has recently been treated or that contains a non-resorbable filler.
  • Do not inject at the same time, and same area, as botulinum toxins.
  • Not for use with laser treatment, chemical peeling, or dermabrasion.
  • For twelve hours after injection, patient should not use makeup.
  • For two weeks after injection, patient should avoid prolonged exposure to sun, UV rays, cold temperatures, or heat, including sauna and steam rooms.
  • Not for injection into glabellar wrinkles, because of necrosis risk.
  • Only for use by trained healthcare professionals who have appropriate training and experience and who have anatomy knowledge of injection site and surrounding area.
  • Do not re-use because sterility cannot be guaranteed.
  • Do not re-sterilize.

Side Effects

  • Inflammation, including redness, erythema, edema, swelling, pain, and hyperthermia.
  • Itching and burning sensation.
  • Irritation, tenderness, and paraesthesia (tingling).
  • Bleeding, bruising, hematoma, and telangiectasia (spider veins).
  • Vascular occlusion (blood vessel blockage).
  • Formation of non-inflammatory and inflammatory nodules (lumps and bumps), induration (hardening), and asymmetry.
  • Skin discoloration. This is generally from superficial injection, causing a bluish discoloration called the Tyndall Effect. Sometimes from ischemia, if vein is blocked causing redness, or whiteness and blanching from a blocked artery.
  • Hyperpigmentation, especially in Fitzpatrick phototyping scale IV to VI skin types.
  • Hypersensitivity or allergic reactions that may be delayed, including urticaria (hives), anaphylaxis, or Quincke's edema.
  • Ocular and periorbital complications causing conjunctival infection, corneal edema (swelling), hyphema (blood in eye), ptosis (drooping), ophthalmoplegia (muscle weakness), or haemolacria (blood in tears).
  • Delayed inflammation, with persistent erythema (redness), formation of acne papules, or ecchymosis (bruising).
  • Infection, abscess, biofilm formation, or herpetic lesion recurrence in those with previous herpes.
  • Migration, displacement, or dislocation of gel.
  • Formation of non-inflammatory or inflammatory granulomas (foreign body reactions).
  • Dermal fibrosis, ulcer, scarring, or cellulitis (bacterial infection).
  • Lack of efficacy or a reduced effect.
  • Rarely, necrosis (tissue death).
  • Rarely, ocular and periorbital complications including temporary or permanent vision impairment to blindness, diplopia (double vision), and xanthelasma (fat deposits near eye).
  • Rarely, headache, dizziness, nausea, and vomiting caused by retinal or cerebral artery occlusion (blockage) or stroke.
  • Rarely, non-thrombotic pulmonary embolism, alveolar hemorrhage, or ground glass opacities in the lung,with dyspnoe (shortness of breath) or cough.
  • Rarely, formation of sarcoid granulomas (masses) in those with hepatitis C and interferon treatment.
  • Rarely, osteitis (bone inflammation).
  • Rarely, cerebral ischemia (inadequate blood supply) and cerebral hemorrhage or stroke.
  • Rarely, hypopigmentation (loss of skin color) in Fitzpatrick phototyping scale IV to VI skin types.

Reactions may be immediate or delayed. If reactions last longer than a week, patient should report them to a physician immediately. These may not be all the possible side effects.

Frequently Asked Questions


What is ETERMIS 3?

This dermal filler helps correct moderate wrinkles and enhances lips. The monophasic and cohesive hyaluronic acid gel helps provide lasting volume with a smooth and natural-looking consistency. This filler also contains mannitol, an antioxidant that acts as a free radical scavenger, reducing hyaluronic acid degradation for lasting results. A low extrusion force and low rate of adverse events make this a comfortable treatment with a good safety profile.

When should I use this dermal filler?

  • The results of this dermal filler usually last about twelve months, depending on the patient's age, gender, skin quality, lifestyle, injection area, and other factors.
  • Your patients should get another treatment about once a year to maintain their results.

Why do doctors use this dermal filler?

Dermatologists, plastic surgeons, and other doctors use this dermal filler to restore a more youthful look to aging skin. This hyaluronic acid filler can correct moderate wrinkles such as marionette lines and nasolabial folds, and you can also use the filler for lip enhancement, adding shape and volume to aging lips.

How does ETERMIS 3 work?

This dermal filler contains a smooth, cohesive hyaluronic acid gel. Hyaluronic acid tends to hold moisture within skin, and this added moisture can help plump volume within the dermis to smooth the appearance of wrinkles. The smooth consistency provides natural-looking results. With mannitol added to the hyaluronic acid, this filler gains antioxidant properties, acting as a free radical scavenger. This helps protect the hyaluronic acid from degradation, providing longer-lasting results.

When and how do I use ETERMIS 3?


How do I use this dermal filler?

You should inject this filler about once a year to maintain smooth-looking skin. Use a needle to inject the gel into the mid to deep dermis of the area affected by wrinkles. After injection, gently massage the treated area to ensure the gel is uniformly distributed.

  1. Inject about once a year.
  2. Use a needle to inject into the mid to deep dermis.
  3. Gently massage treated area to ensure uniform distribution.

Can this dermal filler be combined with other treatments?

Do not inject into an area with a permanent filler. Do not combine these injections with botulinum toxin, laser, chemical peel, or dermabrasion, in the same location at the same time.

How do I store ETERMIS 3?

Store between 2° C and 25° C (35.6° F and 77° F). Do not expose to heat or frost and do not freeze. Keep away from light. Avoid impacts.

Where can I buy ETERMIS 3?

You can buy ETERMIS 3 online at Doctor Medica by choosing a quantity and adding to cart. You can also phone a helpful customer service associate to order this dermal filler or other cosmetic and medical supplies.

Additional Information

ETERMIS 3 Website
Merz Aesthetics Corporate Website
More Mannitol Information

Through, cosmetic and orthopaedic products are offered wholesale to licensed practitioners, clinics and hospitals. Go to, call 1-866-343-2413, or e-mail for more information.

*Doctor Medica offers only genuine products from the original manufacturers. All brands listed here are the trademarks of their respective owners and Doctor Medica is not affiliated with them in any way.

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