Juvederm versus Restylane: Which Dermal Filler is Best?


Juvederm and Restylane are two of the most popular dermal filler brands, used by dermatologists and plastic surgeons around the world. When choosing a dermal filler, there are many factors to consider: how long it lasts, what type of material it is made of, how smooth is it, its filling ability, if it includes an anesthetic, how much it costs, and so much more. Some fillers even offer special ergonomic syringes and injector devices to make them more comfortable to use. With all the different dermal fillers to choose from, it can be overwhelming. Although it ultimately comes down to personal preference, Juvederm and Restylane do have some differences that might help you decide which dermal filler is right for you and your patients.


What is it made of?

Restylane dermal fillers are made of non-animal hyaluronic acid (NASHA) gel.

What types of fillers are available?

This dermal filler brand is available as regular Restylane, Restylane Lyft with thicker particles more suitable for volume-filling, products meant especially for the lips, and a variety of Skinboosters to help rehydrate and rejuvenate skin.

How long does it last?

The Skinboosters are a little different, requiring multiple treatments to maintain results, but most of the other Restylane injectables last about six months to a year after one treatment. Some research has suggested results can even last up to eighteen months.

Do these dermal fillers contain an anesthetic?

Some Restylane products are available with or without an anesthetic, Lidocaine, while some are only available with Lidocaine included. This could be an advantage since some patients are unable to use fillers containing an anesthetic.

What is its filling ability?

Each Restylane product has a different filling ability, ranging from Skinboosters to add hydration and Restylane for nasolabial folds and moderate wrinkles up to Lyft to restore lost volume. The gel has a slightly granular consistency versus Juvederm.

Is there anything else to know about Restylane?

Some Restylane products, formerly called Emervel, are made with a thorough purification process. This purification removes excess bacterial proteins which might otherwise cause a reaction. This may reduce the chance of patients experiencing skin irritation, an advantage for sensitive skin.


What is it made of?

Juvederm dermal fillers are made of non-animal, cross-linked hyaluronic acid gel, similar to Restylane.

What types of fillers are available?

This dermal filler brand is available in Juvederm 2, 3, and 4, for correcting moderate wrinkles up to restoring lost volume. The brand also has Hydrate and Volite for hydration and fine lines, Voluma and Volift for volume restoration, and Ultra Smile or Volbella for lip augmentation.

How long does it last?

Most of the dermal fillers in this brand last between six months to a year, with some lasting up to eighteen months. The one hydrating injectable, Volite, has results that last about six to nine months. What sets this mesotherapy injectable apart from most other brands is that the long-lasting hydration comes from just one injection. Most other brands, including Restylane, require a series of injections at first to restore hydration to skin.

Do these dermal fillers contain an anesthetic?

Almost all Juvederm injectables contain the anesthetic Lidocaine. Although this is great for pain relief, it does not leave any options for patients who are allergic to the anesthetic or who cannot have the anesthetic for other medical reasons.

What is its filling ability?

Each Juvederm product has a different filling ability, ranging from restoring hydration and filling fine lines to correcting moderate wrinkles and nasolabial folds up to volume restoration. The product range is similar to what Restylane offers. Juvederm fillers are created using special Vycross technology to produce a smooth and soft gel for natural-looking results.

Is there anything else to know about Juvederm?

There are concerns that Juvederm may not be suitable in the under-eye area, since it attracts too much water, swelling too much in the area and causing the Tyndall effect, which is a bluish discoloration. In this one particular region of the face, Restylane is more suitable.

Which is better, Restylane or Juvederm? The verdict

Both fillers are made of similar ingredients and come in a variety of products to correct fine lines, moderate wrinkles, deeper wrinkles, or volume loss, along with lip fillers and hydrating injectables. They last a similar amount of time, although this varies from product to product, but Juvederm Volite in particular requires fewer initial treatments to hydrate skin than the Restylane Skinboosters. Although some Restylane products are available with or without Lidocaine, almost all Juvederm fillers contain Lidocaine, which could be a problem for some patients who cannot have anesthetic. Some Restylane Skinboosters have the advantage of a comfortable injector which pre-measures hyaluronic acid gel, making treatments quicker and easier for the one administering the injections. Restylane has been around longer, but Juvederm has also been available for many years, both proving their safety in countless procedures. The two fillers have different consistencies, with Restylane's granular formula possibly more suitable for filling deeper wrinkles and Juvederm's smoother formula more suitable for treating wider areas since it may spread more. Ultimately, each brand of filler has its own advantages, and may be more suitable for one application versus another. In many cases, it may be just a matter of personal preference which filler to choose.

Juvederm may be better than restylane for nasolabial folds in Chinese patients

Although Juvederm Ultra Plus was tested in non-Asian populations, and proven effective for correcting severe nasolabial folds, evidence of safety and effectiveness in Asian patients was lacking. Since a previous study had found coarse wrinkles to be among the strongest signals of perceived age in Chinese women, a group of researchers tested the popular filler, along with Restylane for comparison, in 124 Chinese women and men. For the study, the researchers assessed the severity of each participant's nasolabial folds on a scale of 1 to 5. Doctors treated each participant with Juvederm Ultra Plus on one side and Restylane on the other side, then followed up after one month, six months, nine months, and a year. After one month, the participants were allowed to have a touch-up treatment up to 1.5 ml, up to 0.5 ml per nasolabial fold if needed.

The study participants were classed as a responder six months after treatment if their nasolabial folds improved by at least one point. To check safety, the patients recorded responses at the treatment site for the first 28 days, and the doctors were asked to rate the ease of use of the filler and whether there were any medical device or needle malfunctions during the procedure.

The study results

The practitioner performing the injections determined how much filler they needed to use for effective treatment, and it turns out that Restylane required an average of 1.0 ml of filler, ranging from 0.3 ml to 1.5 ml, while Juvederm only required an average of 0.8 ml of filler, ranging from 0.3 ml to 1.5 ml. Slightly fewer Juvederm patients required follow-up treatments after one month, at 27 versus 29. It seems that Juvederm required less volume for treatment, a potential advantage for practitioners or their patients who are hoping to save money by using less filler.

Although Restylane did have one device malfunction, Juvederm had none. Almost twice as many initial Juvederm injections were rated as very easy to handle, so it seems more practitioners enjoyed using Juvederm than Restylane.

The main goal of the study was to evaluate the effectiveness of Juvederm Ultra Plus for treating nasolabial folds. Six months after treatment, 90.4% of the Juvederm recipients had at least one point improvement in their nasolabial fold severity. This is compared to 89.6% of the Juvederm recipients. It seems that in the Chinese population, Juvederm may be more effective at correcting nasolabial folds, resulting in a more youthful appearance.

Although the doctors saw measurable improvements in their patient's wrinkles, what matters most is how the patients feel about their treatment. As the six month mark, 87.3% of Juvederm patients reported visible improvements versus 83.9% of Restylane patients. Almost half of the study participants noticed a difference between the fold treated with Juvederm and the fold treated with Restylane, and of these patients, 62.1% preferred the nasolabial fold injected with Juvederm. It seems that patients were happier with their Juvederm results.

Safety is also important, and about the same number of patients reported minor side effects with Juvederm as with Restylane. Swelling and tenderness occurred with both fillers, but Juvederm recipients were more likely to experience firmness while Restylane recipients were more likely to experience lumps. Restylane recipients were more likely to experience severe treatment site responses, but Juvederm's responses seemed to last longer, likely due to its larger needle size.

This study seems to suggest Juvederm Ultra Plus is better for treating nasolabial folds than Restylane, at least in Chinese patients. More practitioners found Juvederm to be easy to use, less filler was required, there were fewer severe side effects, and practitioners and patients seemed to see better results with Juvederm versus Restylane. All this adds up to suggest Juvederm may be a better choice in this type of wrinkle with this demographic.

To view the range of Juvederm and Restylane products available, to compare prices, or to purchase these fillers for your medical practice, visit DoctorMedica.co today.

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