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The Saypha dermal filler range is developed by Croma-Pharma using high-quality, biodegradable, and non-animal derived hyaluronic acid in a sterile, non-soluble gel implant. This treatment is CE certified to smooth out lines and wrinkles, contour areas such as the cheeks and chin, and add volume to the lips. FDA has approved the use of hyaluronic acid fillers because they only remain temporarily and get absorbed by the body over time. With over 40 years of expertise, Croma-Pharma is a trusted source of safe and effective hyaluronic acid-based cosmetic fillers. As well, Saypha also offers skincare products, such as facial masks, so patients can continue to see results from home.

What Makes A Good Candidate?

You can recommend Saypha treatments to individuals looking for a safe and effective temporary solution for nasolabial folds, marionette lines, thinning lips, and hollow cheeks.

Adult patients over the age of 21 can choose from a wide range of Saypha products available in the market. There are formulations with added lidocaine to minimize discomfort and increase treatment adherence. Patients requiring a boost in hydration can choose the variant with added glycerol (Saypha Rich). As well, those will dull or dry skin, can benefit from the Saypha skincare line. They are also suitable for use after aesthetic treatments.

Areas Treated with Saypha

The naturally occurring, resorbable hyaluronic acid can be injected into almost any area in the face; although, one must make sure not to inject the product into the blood vessel as it can cause permanent complications. Saypha provides long lasting benefits for these problem areas:

  • Forehead creases;
  • Temples;
  • Nasolabial folds;
  • Perioral wrinkles;
  • Marionette lines;
  • Lip volume.

How Does Saypha Work?

The main component of Saypha dermal fillers is hyaluronic acid or hyaluronan—a non-sulfated glycosaminoglycan that is essential in keeping skin firm, hydrated, and elastic. The level of hyaluronic acid in the body decreases as people age, and it further depletes in a faster rate when the skin is often exposed to UV rays and other harmful environmental factors.

The hyaluronic acid in Saypha products is created through biofermentation, using their ground-breaking technology known as Supreme Monophasic and Reticular Technology (SMART). The meticulous process creates a type of hyaluronic acid that mimics what is produced in the human body. This way, hypersensitivity is avoided and long-term adverse effects rarely occur.

Different products in the Saypha filler range are formulated to address specific needs of each patient. By injecting any of these hyaluronic acid fillers into the skin, visible signs of aging are adequately taken care of. Patients will experience reduced visibility of lines and folds, restored volume and elasticity, and increased skin hydration.

Treatment Details

Choose a Saypha product with added lidocaine for highly sensitive areas of the face. Topical anesthesia can also be applied for products that do not contain lidocaine. The gel implant is then injected into the mid to deep dermis, depending on the depth of wrinkle to be corrected. Gently massage the treated area to ensure even distribution of the gel underneath the skin. If additional dose is needed, the second injection must be done within 14 days. Saypha Rich is administered over 3 sessions at a 2 to 3-week interval.

Saypha skincare products can be used by patients safely in their home. Refer to the product pamphlet for details.

How Long Does Saypha Last?

The Saypha dermal filler range provides a safe and highly effective solution for various skin imperfections. The results are temporary, but can last up to 12 months, depending on which filler is used.

Safety Information

This treatment was evaluated using an open-label uncontrolled, multi-center study and showed a 97.9% subject satisfaction rate and scored 97.9% on Global Aesthetic Improvement Scale (GAIS). Certain individuals may not be suitable to receive these fillers or use the skincare products. Take a full medical history of each patient. The whole procedure, including potential adverse effects and complications, must be discussed with your patients before the initial session.

Cautions and contraindications:

  • Pregnant and breastfeeding women;
  • Patients, who are prone to hypertrophic scarring;
  • Patients with known hypersensitivity to hyaluronan, lidocaine, and gram-positive bacterial proteins;
  • Areas with cutaneous, inflammatory conditions or active infection.

Recovery Time

The procedure takes approximately 15 to 30 minutes, and the patient can go home and resume daily activities immediately afterwards. Post-treatment discomfort is mild and temporary, usually disappearing in less than 7 days. Patients may expect redness, swelling, tenderness, or bruising at the site of injection.

Cost of Saypha

Depending on the desired result and chosen product derivative, the cost of each Saypha filler and mesotherapy injectable pack ranges from $80 to $900.

Please note that Princess has recently been rebranded to Saypha. However, Princess’s mask products are still sold under the Princess brand. You can find Princess masks here.

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