Beyond the Lab: Orthovisc and Biotechnology Advancements

According to the Global Osteoarthritis Patient Perception Survey (GOAPPS), more osteoarthritis (OA) patients seek additional treatments to manage joint pain. These patients prioritize non-pharmaceutical and minimally invasive interventions, highlighting a growing demand for enhanced management interventions in OA healthcare.

Fortunately, advancements in biotechnology are paving the way for innovative treatment options. One such example is Orthovisc, a product that harnesses the power of biotechnology to address knee osteoarthritis. As a hyaluronan injectable, Orthovisc mimics the natural joint fluid to lubricate and cushion the bones. This injection delivers enhanced joint function and patient comfort.

In this article, we will explore Orthovisc’s use of the latest biotechnology advancements to relieve knee pain experienced by OA patients and allow them to recover their mobility and quality of life.

Key Takeaways

• Orthovisc is a viscosupplement used to treat osteoarthritis, relieving pain and stiffness in the knee joint.
• It replenishes the natural lubricating fluid in the joint, reducing friction and inflammation for improved joint function.
• The development of Orthovisc showcases the intersection of biotechnology advancements and orthopedic medicine, offering hope and relief to individuals living with osteoarthritis.

Understanding Orthovisc

Orthovisc represents a significant advancement in treating knee pain associated with osteoarthritis. It is part of a category of viscosupplements designed to alleviate pain and improve joint function through a non-surgical approach. The active ingredient in Orthovisc is hyaluronan, better known as hyaluronic acid (HA), and it acts similarly to the fluid surrounding the joints.

Because of osteoarthritis, the natural HA within the joint becomes degraded and lessens. Now that the joint lacks sufficient HA, individuals afflicted with osteoarthritis experience increased friction, inflammation, and pain during movement. Orthovisc injections replenish the HA within the joint, offering several potential benefits:

• Improved lubrication: The injected HA acts as a lubricant, reducing friction between the bones within the joint and allowing for smoother movement.
• Enhanced shock absorption: HA helps to absorb shock and distribute pressure more evenly within the joint, protecting the cartilage from further damage.
• Pain relief: Orthovisc can help reduce osteoarthritis pain by improving lubrication and shock absorption.
• Increased joint function: With reduced pain and improved joint mechanics, Orthovisc may help to improve your range of motion and overall joint function.

A healthcare provider directly injects Orthovisc into the knee joint. Patients may receive a series of injections, typically one per week for three to four weeks. The goal is to restore adequate levels of hyaluronic acid in the joint, which can relieve pain for several months.

Differences Between Orthovisc and Traditional Osteoarthritis Treatments

Various treatment options are available when managing osteoarthritis. Orthovisc, as a viscosupplement, offers a different approach than traditional treatments. Here’s a detailed comparison between these treatments:

• Type of Treatment: Traditional treatments for osteoarthritis often include painkillers, anti-inflammatory drugs, corticosteroid injections, and surgery for severe cases. Orthovisc is a non-surgical treatment involving injecting hyaluronic acid into the knee joint.
• Principal Component: The main components in traditional treatments can vary from analgesics and steroids to the physical components used in surgery. Orthovisc’s main component is hyaluronic acid, a substance naturally found in the synovial fluid of joints.
• Method of Action: Traditional treatments generally focus on reducing pain and inflammation or repairing and replacing damaged joint components. Orthovisc works by restoring the natural viscoelasticity of the synovial fluid, which helps lubricate and cushion the joint.
• Application: Traditional treatments can be oral, topical, or invasive surgical procedures. Orthovisc goes directly into the knee joint through intra-articular injections.
• Pain Relief Duration: Pain relief from traditional treatments can be short-term and may require ongoing or repeat interventions. Orthovisc provides longer-lasting pain relief, lasting up to six months after an entire treatment cycle.
• Suitability: Traditional treatments are suitable for a broad range of osteoarthritis patients, including different stages of the disease. Orthovisc is particularly beneficial for patients who have not responded adequately to other non-surgical treatments.
• Research and Development: Traditional treatments have been developed over many years and are well-established in medical practice. Orthovisc represents a newer class of treatments, with ongoing research focusing on the long-term benefits and potential applications in other joints beyond the knee.

The Role of Viscosupplements in Joint Care

Viscosupplements like Orthovisc are crucial in managing joint pain, particularly in osteoarthritis. They aim to improve the quality of the synovial fluid, which diminishes in quantity and quality in arthritic joints. 

Here’s how viscosupplements like Orthovisc fit into the broader picture of joint care for osteoarthritis:

• First-line Therapy: Typically, doctors recommend conservative measures like exercise, weight management, and pain relievers for managing OA symptoms. Doctors may suggest viscosupplementation after these initial approaches haven’t provided sufficient relief.
• Pain Management: Orthovisc can be a valuable tool for managing pain associated with OA. Studies suggest it can offer pain relief that lasts for several months.
• Improved Function: By reducing pain and stiffness, viscosupplements can help to improve your ability to perform daily activities and maintain an active lifestyle.
• Delayed Joint Replacement: In some cases, viscosupplementation may help to delay the need for joint replacement surgery by managing symptoms and slowing down the progression of OA.

Hyaluronic acid’s viscoelastic properties enable it to act as a lubricant, facilitating smoother joint movement and providing cushioning against impacts. However, viscosupplementation is not a cure for osteoarthritis. 

It’s also important to note that the effectiveness of viscosupplementation can vary among individuals. Some patients may experience significant pain relief, while others may not find it as beneficial. The treatment is generally considered safe, with a risk profile similar to a placebo in clinical studies.

The Science Behind Orthovisc

Orthovisc is a product of ongoing research and development efforts to find practical solutions for osteoarthritis (OA). Here’s a detailed look at the science behind Orthovisc.

Research and Development of Orthovisc

The development of Orthovisc involved comparing its rheological properties with those of healthy knee synovial fluid. Studies aimed to ensure that products like Orthovisc would have properties similar to those of the natural fluid found in a healthy joint, thus restoring the joint’s natural function.

The research indicated that Orthovisc’s linear chain structure and molecular weight closely resemble healthy knee synovial fluid. These developments in research also help enlighten individuals who ask questions such as, “Does Orthovisc really work?” or if it can relieve pain,  making it a suitable treatment option for knee osteoarthritis.

Formulation and Composition of Orthovisc

Orthovisc is a high-molecular-weight hyaluronan, a viscous mixture of highly purified hyaluronan derived from rooster combs. Hyaluronan is a natural substance in the body, particularly in joint tissues and the fluid that fills the joints.

Even with less weight, its power to ease the pain from osteoarthritis is strong because of how many active components are inside. Moreover, the formulation of Orthovisc features a biocompatible design, meaning it is well-tolerated by the body and minimizes the risk of adverse reactions.

Safety and Efficacy Studies

Clinical trials have evaluated the safety and effectiveness of Orthovisc in providing pain relief for patients with knee osteoarthritis. These studies have shown that Orthovisc is safe and can effectively treat mild to severe osteoarthritis of the knee. The treatment is associated with a safety profile similar to saline injections, even during retreatment.

However, individuals interested in this treatment should still consider that the effectiveness of Orthovisc can vary, depending on factors like the severity of a patient’s osteoarthritis or individual differences. More research is ongoing to understand the long-term effects of Orthovisc further and its potential role in managing OA progression.

Long-Term Benefits of Orthovisc for Osteoarthritis Patients

Osteoarthritis (OA) is a chronic condition, and managing its symptoms requires a long-term approach. While Orthovisc isn’t a cure, it can offer several long-term benefits for OA patients. Below, we explore the duration of relief and improved joint function, as well as the impact on the quality of life for those who have undergone this treatment.

Duration of Relief and Improved Joint Function

Orthovisc injections offer symptomatic relief for knee osteoarthritis. The treatment involves a series of injections that can lead to significant pain reduction and enhanced joint mobility. 

The effects of Orthovisc can last up to six months, providing long-term relief from the symptoms of osteoarthritis. This extended period of relief can significantly improve joint function, allowing patients to engage in daily activities with less discomfort and greater ease.

Impact on Quality of Life

The pain and limited mobility caused by osteoarthritis can severely impact the quality of life of patients who suffer from this degenerative disease. However, Orthovisc offers long-term benefits, such as the following:

• Increased Mobility: Reduced pain and improved joint function can lead to increased mobility and independence in daily activities. You can walk, climb stairs, and participate in hobbies more easily.
• Enhanced Physical Activity: With less pain, you may be more inclined to engage in physical activity, which is crucial for maintaining overall health and managing OA in the long term.
• Improved Mental Well-being: Chronic pain can significantly impact mental well-being. Orthovisc’s long-term pain relief can contribute to improved mood, reduced stress, and a better overall sense of well-being.

Patient Success Stories and Testimonials

Orthovisc has changed the lives of many osteoarthritis patients. Stories and testimonials shared on WebMD highlight how many patients this treatment has helped by relieving the pain in their joints. Moreover, actual patients sharing their experience with this treatment helps others know what to expect after Orthovisc injections.

One of the top-rated reviews on this forum comes from a senior female patient who received Orthovisc because she didn’t find relief with other treatments like cortisone shots.

Since nothing seemed to be working, this patient’s doctor recommended Orthovisc. Although she didn’t feel relief during her first shot, it was because of the second shot that the patient started regaining mobility and experiencing pain relief in her knees. 

According to this patient, her knee completely cooperated with her, allowing her to perform activities such as hiking and biking. She recommends Orthovisc to others going through the same thing as her, claiming that she sees Orthovisc as a small miracle.

Another female patient, Billie, highly recommends Orthovisc to others with knee osteoarthritis. According to Billie, Orthovisc injections have given her her life back. Now, she walks without pain. She feels better with each series of shots and loves how the relief lasts longer.

The Future of Joint Care

The viscosupplementation market is experiencing significant growth, driven by the increasing prevalence of osteoarthritis and musculoskeletal disorders, particularly among the aging population. Continuous advancements in product development and the extension of applications to various joints are fueling further market growth.

Biotechnology holds the potential to revolutionize osteoarthritis treatment. Advances in stem cell-based therapies have shown promise in contributing to cartilage repair, anti-inflammatory modulation, and immune regulation in OA patients.

Moreover, developing mammalian protein production platforms and transfected protein packaging cell lines could lead to the over-production of therapeutic proteins and growth factors, enhancing intra-articular regenerative therapies.

The future of joint care looks promising with the integration of biotechnology and ongoing research in viscosupplements. Many expect these advancements to provide more effective, long-lasting, and minimally invasive treatment options for osteoarthritis patients, significantly improving their quality of life.

Conclusion

Orthovisc represents a prime example of how biotechnology advancements are shaping the future of healthcare, particularly in orthopedic medicine. By harnessing the power of biotechnology, researchers have developed a treatment that offers hope and relief to millions of individuals living with osteoarthritis. 

As ongoing research continues to uncover new insights and innovations, the potential for Orthovisc and other biotechnology-based treatments to transform joint care remains promising.

About: DoctorMedica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices in the market. Whether you need a specific product or various options, we can help you find the best deals for your needs. Plus, you can enjoy our promotions and free shipping for orders over $500. With DoctorMedica, you can offer your patients the best results for less.

FAQs

1. What is Orthovisc?

Orthovisc is a viscosupplement injection containing hyaluronic acid. Doctors use it to treat knee pain associated with osteoarthritis by lubricating and cushioning the joint.

2. How long do the effects of an Orthovisc injection last?

On average, the effects of an Orthovisc injection typically last between 4 to 6 months.

3. What should I do after getting Orthovisc treatment?

After receiving Orthovisc treatment, refrain from strenuous activities for 48 hours and follow other post-injection care instructions from your provider.

References

Vitaloni M, Bemden ABV, Sciortino R, et al. A patients’ view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study. BMC Musculoskeletal Disorders. 2020;21(1). doi:10.1186/s12891-020-03741-0

Drugs & medications. https://reviews.webmd.com/drugs/drugreview-81236-orthovisc-intra-articular?conditionid=2810&sortval=2&next_page=true