PLINEST®

PLINEST® at a Glance

PLINEST® is an injectable Class III medical device formulated with PN-HPT™ (Polynucleotides – Highly Purified Technology). It’s designed for intradermal use to improve skin texture, elasticity, and hydration through bio-regeneration.

• Composition: PN-HPT™ 40 mg/2 mL, sterile, non-pyrogenic, viscoelastic gel
• Format: 1 prefilled syringe + 2 x 30G ½ needles
• Indications: Prevention, maintenance, and recovery in photo-aged or fibrotic skin

Performance Benefits for Clinical Use

PLINEST® shows measurable clinical improvements in skin quality with a strong safety profile. Used across 143 patients, results confirm visible and quantifiable skin improvements after 3–4 sessions.

• 91% of patients showed clinical improvement (73% improved, 18% highly improved)
• +14.7% increase in hydration (baseline vs post)
• +21.8% improvement in elasticity
• 16.7% reduction in skin roughness within 30 days
• No severe side effects reported; high tolerability confirmed

Available PLINEST® Options – Product Range

PLINEST®

• Standard formulation for skin bio-regeneration and wrinkle reduction
• Targets face, neck, and décolleté

PLINEST® ONE

• 2 mL monodose for flexible, targeted treatment areas
• Suitable for scarring, photoaging, and sensitive zones

PLINEST® EYE

• For the periocular area to treat fine lines, tone, and laxity
• Adapted for low-tolerance regions

PLINEST® HAIR

• For scalp regeneration in androgenic alopecia or telogen effluvium
• Promotes microcirculation and follicular support

Ideal PLINEST® Use Cases and Patient Profiles

Designed for bio-repair and aesthetic priming across multiple patient profiles, PLINEST® suits a range of preventive and corrective treatments.

• Younger skin prevention: 3 sessions, 1 every 3 weeks
• Aging skin recovery: 4 sessions, 1 every 1–2 weeks
• Maintenance: Every 1–3 months
• Suitable for acne scars, neck/décolleté, and skin priming before energy-based procedures

PLINEST® Core Ingredients and Their Roles

PLINEST® contains high-purity DNA fragments that stimulate dermal cell activity and collagen synthesis. These polynucleotides support hydration, repair, and elasticity.

• PN-HPT™: Long-chain deoxyribonucleotide polymers
• Restores dermal structure through fibroblast stimulation
• Promotes angiogenesis, hydration, and re-epithelialization
• Safe due to high biocompatibility and purification

PLINEST® Injection Techniques and Application Guide

Injections should be intradermal, performed by a qualified medical professional. Protocols are tailored to indication.

• Face/Neck/Décolleté:
  • 2 mL/session intradermally via micro-droplets or linear retrograde
  • 30 micro-droplets of 0.1–0.2 mL per point
  • 3 sessions, spaced 14–21 days
• Scarring: 4 mL per session, every 3 weeks, total of 2–3 sessions
• Combine with fillers, lasers, RF, peels, or needling for enhanced synergy

PLINEST® Storage, Shelf Life, and Handling

PLINEST® must be stored and handled according to device guidelines to maintain sterility and performance.

• Sterile, single-use, non-pyrogenic
• Keep in original packaging
• Store under controlled room temperature (specific range not stated in leaflet)
• Do not reuse or resterilize

PLINEST® Side Effects: What to Monitor

Clinical tolerance is high with minimal adverse events reported. Most reactions are mild and self-resolving.

• Injection site reactions: Possible redness, swelling, or mild discomfort
• No serious adverse events observed in clinical trials
• Avoid injecting in infected or inflamed areas

Key Practitioner Questions About PLINEST® Answered

How many treatments are needed?

• Younger skin: 3 treatments, every 3 weeks
• Aged or scarred skin: 4 treatments, every 1–2 weeks
• Follow-up: Maintenance every 1–3 months

Where can it be injected?

• Face, neck, décolleté, and scalp (HAIR)
• Avoid periorbital injections unless using PLINEST® EYE

Can it be combined with other procedures?
Yes. PLINEST® is effective as a priming agent before lasers, peels, microneedling, RF, and fillers.

What is the injection depth?
Intradermal, using micro-droplet or retrograde techniques.

How to Order PLINEST® for Your Practice

PLINEST® is a CE-certified Class III medical device available through licensed medical distributors. Only certified practitioners may purchase and administer the product.

Order PLINEST® online at Doctor Medica today!

Written by Doctor Medica’s Editorial team

The content on this page has been written and fact-checked in accordance with our Editorial Policy. Clinical claims are sourced from peer-reviewed literature, regulatory documentation, and manufacturer specifications. Where citations are provided, it is always in accordance to our editorial standards.