DUROLANE®

Knee Osteoarthritis: Symptoms and Treatment

Knee osteoarthritis (OA), a degenerative joint disease, typically arises from wear and tear, especially common among the elderly. OA progresses gradually and can lead to rheumatoid arthritis and even disability. Symptoms, including knee pain intensified by activity, stiffness, swelling, and worsening discomfort over time, vary in severity and frequency. While medications may slow RA progression, there are no confirmed disease-modifying agents for knee OA. 

While weight loss can significantly reduce the symptoms of knee osteoarthritis, continued treatment may be needed to manage the chronic condition, with exercise, physiotherapy , painkillers, and possible joint replacement surgery. Some patients may require sodium hyaluronate injections which mimic the nature of joint fluid, and provide cushioning and lubrication to prevent pain, inflammation and mobility issues associated with osteoarthritis.

Read our comprehensive article on Durolane Dosage.

Buy DUROLANE® Online for Effective Treatment: Benefits and Characteristics

What to know before you order DUROLANE® online? DUROLANE® is an innovative remedy in the management of knee pain from osteoarthritis, offering a natural, non-opioid alternative which is non-addictive. This particular treatment uses hyaluronic acid, which is known for its lubricating and shock absorbing properties once inside the knee joint. What sets DUROLANE® apart? Its meticulously stabilized concentration of hyaluronic acid, designed to resist degradation, prolonging its presence in the joint and enhancing its enduring efficacy. 

Its safety for repeated therapy courses and superior longevity in pain relief compared to steroid injections underscore its results in osteoarthritis management. Moreover, the derivation of hyaluronic acid from a non-animal source mitigates the risk of allergic reactions, further solidifying DUROLANE®’s appeal as a reliable treatment option.

The Superior Hyaluronic Acid Solution

Hyaluronic acid (HA) serves as a fundamental molecule naturally present throughout the human body, particularly crucial in joint fluid, known as synovial fluid. Within the context of normal, healthy knees, it plays a pivotal role in furnishing lubrication and cushioning. However, in the presence of osteoarthritis, the breakdown and dilution of hyaluronic acid occur, diminishing its innate elastic properties. Consequently, this deterioration contributes to the further erosion of cartilage tissue and heightened joint discomfort. 

The hyaluronic acid formulation in DUROLANE® mirrors the composition of the body’s natural counterpart, albeit in a concentrated form, uniquely stabilized to counteract the degradation induced by osteoarthritis. This specialized formulation is administered through a single-injection directly into the knee, offering targeted relief.

DUROLANE® vs Competition

Since its global introduction in 2001, DUROLANE® has undergone extensive clinical scrutiny, surpassing any other single-injection hyaluronic therapy in research studies. DUROLANE® has been clinically proven to be equivalent in effectiveness to five hyaluronic acid injections: the conclusion is that Durolane (one injection) is non-inferior to Artz (five injections). 

Furthermore, compared to direct intrathecal steroid injections, DUROLANE® provided longer pain relief. In direct comparison with injectable steroids, DUROLANE® demonstrated superior pain relief. In a level 1 study: DUROLANE® was shown to be as effective as intra-articular steroid injections at 6 weeks. Results indicated DUROLANE’s superiority in reducing WOMAC pain, function, and stiffness scores from weeks 12 to 26. DUROLANE® achieved a significant reduction in WOMAC pain scores from baseline to week 26 compared to steroids.

A single injection of DUROLANE led to significant improvements across all Knee and Osteoarthritis Outcome Score (KOOS) parameters within just 2 weeks, with these enhancements sustained for up to 24 weeks.

Precautions and Contraindications: Safely Administering DUROLANE®

DUROLANE® is specifically intended for alleviating pain associated with knee osteoarthritis (KOA) in individuals who haven’t responded adequately to conservative non-pharmacological therapy or basic analgesics like acetaminophen. 

Refrain from administering DUROLANE® to patients with knee joint infections, skin disorders, or other localized infections. Similarly, individuals with known hypersensitivity or allergic reactions to sodium hyaluronate formulations should not use it, as adverse effects such as temporary pain or swelling at the injection site may occur. Importantly, DUROLANE® has not been tested in pregnant or breastfeeding women, or in pediatric populations.

Buy DUROLANE® for Your Patients

When you buy DUROLANE® wholesale, it ensures authenticity but also offers cost-effectiveness and a reliable supply chain, so you can efficiently manage your inventory, ensuring that you never face shortages, thereby providing consistent care for your patients.

For a secure purchase, it is imperative to acquire DUROLANE® from reputable and licensed sources. Ensure the legitimacy and reliability of the supplier to guarantee the authenticity and effectiveness of the product, thus prioritizing the safety and well-being of patients.