DERMALAX™

About Dermalax®

Dermalax® is a line of Korean dermal fillers produced in Chuncheon, South Korea by Across Co., Ltd., the same medical device manufacturer that produces REVOLAX®, and exported to CE-recognizing markets under a CE-marked classification. Every Dermalax® product is built on the same base chemistry. Cross-linked hyaluronic acid (HA) is produced through bacterial fermentation rather than animal extraction, then stabilized with BDDE. That non-animal origin removes the residual protein contamination that used to complicate first-generation avian HA fillers, and it is now standard across the Korean segment. The current line spans four distinct SKUs at defined HA concentrations, lidocaine content, and needle gauges [4].

Commercial position is the other side of the story. Dermalax® sits in the mid-price Korean HA bracket, more affordable than most Western monophasic gels but not the cheapest CE-marked Korean HA on the market. That places it in the same wholesale tier as REVOLAX® and HYAFILIA®, and the substitution set for a clinic switching brands is small and well defined rather than open-ended.

Dermalax® Product Range – All Four Products

Dermalax® Deep

Contains 24 mg/mL HA with 0.3% lidocaine, supplied with a 27G needle, intended for deep dermal placement in nasolabial folds, moderate-to-severe lines, and cheek augmentation where a full structural lift is not the objective.

Dermalax® Implant Plus

This is the heaviest gel in the range. 24 mg/mL HA with 0.3% lidocaine, supplied with a 25G needle. Formulated for deep tissue placement in the cheek, chin, and jawline, and used for volume restoration in patients with more advanced deflation.

Dermalax® Plus

This is the range’s superficial product. 20 mg/mL HA with 0.3% lidocaine, supplied with a 30G needle for fine-line correction. Sits at the softest end of the line and suits perioral fine lines and superficial etched lines that a Deep-grade gel would over-fill.

Dermalax® Deep

20 mg/mL HA, applied in nasolabial folds and lip work where the injector is managing anesthesia separately, and often the option paired with topical or block anesthesia in longer sessions where the total lidocaine Dermalax® Implant Plus and Deep Plus dose needs to be capped across the visit.

What “Plus” Means

Dermalax® Plus, Deep Plus, and Implant Plus contain 0.3% lidocaine, while Dermalax® Deep does not. Clinics should still confirm the full product name, concentration, syringe volume, and pack size before ordering.

Licensed practitioners looking to buy Dermalax® wholesale can review current product availability, pack sizes, and professional ordering requirements through Doctor Medica. Always confirm local regulations and the correct formulation before purchase.

Cross-Linked HA Technology – How Dermalax® Works

Native hyaluronic acid degrades within days once injected, which is why every long-acting HA filler on the market is cross-linked. Dermalax® uses BDDE (1,4-butanediol diglycidyl ether) as its cross-linker, the same chemistry used across the majority of current CE-marked HA dermal fillers and similar products [3]. Cross-linking knits HA chains into a gel that resists hyaluronidase digestion in tissue, and the density of that network drives both how the gel feels and how much lift it produces.

Rheology tends to be described in terms of G′, the elastic modulus. A gel with higher G′ resists deformation and holds shape under tissue pressure, which is why Implant Plus behaves as a structural product. A gel with lower G′ deforms more freely and integrates into softer tissue, which is why Deep, Deep Plus, and Plus perform better in folds, lips, and fine lines than they would in cheek or chin projection. Cohesivity, particle size, and swelling ratio also influence behavior, so G′ alone does not describe the whole product, but it is the single most predictive number when comparing across the range.

Two other properties are the HA in every Dermalax® product, which is biocompatible and non-animal in origin. The entire line is fully reversible with hyaluronidase, which remains one of the main reasons the cross-linked HA class is preferred over permanent injectables for aesthetic work.

Treatment Areas and Clinical Indications

Dermalax® fillers cover several common facial indications, but each formulation has its own key benefits and intended outcomes.

Nasolabial Folds

Dermalax® Deep Plus is the standard pick for moderate-to-severe nasolabial folds, with Deep used for lighter correction. A multicenter randomized study of Dermalax® Deep in this indication reported sustained correction out to 48 weeks with a safety profile comparable to control [2], which is the strongest supporting evidence for the range in fold work.

Cheeks and Midface

Implant Plus is the primary choice for cheek augmentation and midface volume where structural lift is the goal. Deep Plus can handle lighter contouring where projection is not the objective, but it is not the product to reach for on a fully deflated midface.

Lips and Perioral Areas

Deep and Deep Plus are the Dermalax® lip filler options. Deep is typically preferred in the lip border and for softer lip work, while Deep Plus carries more body for volume-focused cases. For very fine perioral lines that surround the lips, Plus with its 30G needle handles superficial placement that Deep-grade gels would over-correct. Implant Plus does not belong in lip tissue.

Chin and Jawline

Implant Plus is the product used for chin projection and jawline definition. Placement is deep, and the gel’s high elastic modulus does the structural work rather than the injection volume alone.

Dermalax® for Delicate Skin – What Practitioners Should Know

Thin and translucent skin, particularly around the eyes and the lip border, calls for the softest formulations and the most conservative placement. Dermalax® Plus and Deep are the appropriate choices here. Both sit at 20 mg/mL, and Plus’s 30G needle is specifically suited to superficial fine-line work. Implant Plus and Deep Plus are not designed for superficial planes in delicate tissue and can produce visible contour, palpable nodules, or the bluish Tyndall discoloration that appears when any cross-linked HA is placed too shallow in thin skin.

Fine-gauge needles or cannulas reduce trauma but do not remove vascular risk, so anatomy remains central. Swelling in thin skin resolves more slowly than in thicker tissue, so a modest under-correction with review at two weeks is usually a better plan than a full result on the first visit. Prior filler history matters more here than elsewhere, since delayed reactions in previously treated tissue can present as focal swelling that patients read as a treatment failure rather than an immune-related event.

How Long Does Dermalax® Filler Last?

Longevity varies by product and by treatment area. Plus and Deep, placed in superficial fine lines, lips, and folds, typically last around six to nine months. Deep Plus, placed in deeper folds and light cheek work, generally lands in the same six-to-nine-month range, with one randomized trial documenting sustained improvement in nasolabial folds through 48 weeks [2]. Implant Plus, placed for cheek, chin, and deep volume work, usually runs longer, around nine to twelve months. Individual duration varies with metabolism, tissue movement, and volume placed, and clinical studies and real-world outcomes both track this pattern.

Dermalax® reviews from injectors describe duration in line with these figures and consistent with other established Korean HA fillers. In practical terms, that puts the range on comparable footing with REVOLAX® and HYAFILIA® for treatment planning.

Regulatory Status — CE Marking and FDA Position

Dermalax® has not received FDA clearance and is not authorized for sale or use in the United States. The line carries CE marking, which permits sale in the EU, UK, and other jurisdictions that recognize the CE framework, and Across Co., Ltd. also holds ISO 13485 certification for its manufacturing operations.

CE marking is not a substitute for local approval in every market. Practitioners who buy Dermalax® online for a jurisdiction they do not routinely order into should confirm three things before purchasing: whether the product is registered in that market, whether the intended indication falls inside that registration, and whether import and professional-use rules permit direct clinic supply. In markets that do not recognize CE, Dermalax® is not lawful for treatment there regardless of how it was procured.

Dermalax® Compared With Other HA Fillers

vs REVOLAX®

Dermalax® and REVOLAX® are both manufactured by Across Co., Ltd., making this the closest comparison in the group. REVOLAX® runs three formulations, Fine, Deep, and Sub-Q, against Dermalax®’s four. HA concentration sits in the same 20 to 24 mg/mL range for both brands, and both are BDDE cross-linked. REVOLAX® Sub-Q is the specific product for structural nasal and chin work and does not have a direct one-to-one match in Dermalax®, though Implant Plus provides comparable lift for cheek and chin volumizing. Neither range is FDA-approved.

vs NEURAMIS®

NEURAMIS® is manufactured by Medytox, one of the longer-established Korean botulinum toxin and HA houses. Its range includes Light for fine lines, Deep for folds and volume, Volume for cheek augmentation, and Deep Lidocaine, giving it a slightly wider spread than the four-product Dermalax® line. Dermalax® Deep Plus and NEURAMIS® Deep line up closely on HA concentration and cross-linking. Medytox’s manufacturing history gives NEURAMIS® strong brand recognition across parts of the Asian market, while Dermalax® has picked up broader European distribution.

vs HYAFILIA®

HYAFILIA® from HuMedix is a three-product Korean HA range — Classic, Plus, and Grand — frequently singled out for a particularly smooth gel texture. On indication and HA content, HYAFILIA® Plus lines up with Dermalax® Deep Plus, and Grand is the deeper-volume counterpart to Implant Plus. Both brands are CE-marked, both are hyaluronidase-reversible, and neither is FDA-approved. HYAFILIA® has a reasonably well-documented clinical evidence base for its segment; Dermalax®’s published evidence is thinner but concentrated on the fold indications where the range is most used.

vs HYAcorp®

HYAcorp® is manufactured in Germany by BioScience GmbH and is particularly known for higher-volume body contouring products. This makes it a less direct comparison, since Dermalax® is primarily designed for facial use. For facial volume, Dermalax® Implant Plus can be broadly compared with firmer HYAcorp® products such as MLF1 or MLF2. HYAcorp® is generally positioned at a higher price point and carries European manufacturing provenance.

vs PERFECTHA®

PERFECTHA® is manufactured by Laboratoire ObvieLine in France and distributed internationally by Sinclair Pharma. It uses E-BRID® cross-linking to produce a biphasic HA gel, and its range covers Fine Lines, Derm, Subskin, and Complement, with lidocaine variants across the range. On paper, the closest structural pair is Dermalax® Implant Plus against PERFECTHA® Subskin, though Subskin is used in larger volumes for subcutaneous placement, whereas Implant Plus is positioned for facial deep implantation. PERFECTHA® commands a premium consistent with European technology, and Dermalax® is generally the more accessible option on price.

Key Benefits of Dermalax® for Aesthetic Practitioners

Injectors who stock Dermalax® tend to cite a fairly consistent set of key benefits:

• A four-product CE-marked range covering superficial fine lines through structural deep volume without gaps
• 3% lidocaine in three of the four SKUs, plus a lidocaine-free option in Deep for cumulative-dose control across long sessions
• BDDE cross-linked HA in line with the established Korean segment, and full reversibility with hyaluronidase
• Wholesale pricing below most European premium HA brands at comparable viscosities
• A shared manufacturer with REVOLAX®, which many injectors already know and stock

These benefits of Dermalax®, alongside a growing base of injector-side reviews, are what clinics most often cite when moving to the range from higher-priced European lines.

Storage and Handling

Store Dermalax® between 2°C and 25°C, protected from direct sunlight, and never freeze the product. Freezing damages the HA matrix and voids the syringe. Temperature excursions in transit also matter, so cold-chain-appropriate shipping is worth confirming at wholesale volumes even though the product is not strictly refrigerated in the standard sense. On arrival, verify blister integrity, LOT number, expiry date, HA and lidocaine concentrations, and needle size against the current instructions for use before syringes go into clinical storage. Any syringe whose storage history is unclear should not be used.

Side Effects and Immune Reactions

Most Dermalax® side effects are the ordinary injection-site reactions common to any HA filler: bruising, swelling, redness, tenderness, and short-lived firmness at the injection point. These usually settle within a week without intervention. Less common events include delayed inflammatory nodules, prolonged edema, product migration, and hypersensitivity reactions.

The serious risk with any HA filler is intravascular injection or external vascular compression, which can produce tissue necrosis and, in the periorbital and glabellar regions, visual complications through anastomoses with the ophthalmic circulation [5]. Nothing in the Dermalax® formulation elevates that risk relative to peers, but nothing lowers it either. Technique and anatomical knowledge govern outcomes.

Can Dermalax® affect the immune system?

For most patients, no clinically significant immune reaction occurs, since HA is a molecule naturally present in tissue and the standard post-injection changes are inflammatory rather than immune-mediated. However, delayed hypersensitivity to the BDDE cross-linker has been documented across the cross-linked HA class, and regulators have described immune-related inflammatory reactions in patients with a previous filler treatment history, including facial swelling that appeared after later systemic triggers [1]. Pre-treatment screening should cover previous filler reactions, autoimmune history, active infection, and immune-modifying medication, alongside the contraindications in the current IFU.

Buy Dermalax® Filler Wholesale from Doctor Medica

Doctor Medica supplies the Dermalax® filler range directly to licensed aesthetic practitioners and authorized clinics at wholesale. The current listing covers Plus, Deep, Deep Plus, and Implant Plus, so a single order can stock the full viscosity spread the brand offers. Single-unit trial purchases and bulk resupply are both supported, and pricing tiers scale with volume for practices moving predictable weekly or monthly stock. Clients weighing Dermalax® vs JUVÉDERM® for a specific indication can speak with the team on where the two ranges cover overlapping ground and where they do not.

Shipping is arranged to keep the product inside its temperature envelope in transit, and account verification, LOT-based authenticity confirmation, and post-order support come standard. Alongside the broader dermal fillers catalog, the Dermalax® range is one of several Korean HA options carried on the site. To order Dermalax® online at wholesale, add products from the range above or contact the team for a bulk quote.

Frequently Asked Questions

What is Dermalax®?

Dermalax® is a four-product Korean HA filler line from Across Co., Ltd., cross-linked with BDDE and CE-marked. It covers fine lines, lip work, folds, cheek augmentation, and deep volume restoration.

How long does Dermalax® filler last?

Around six to twelve months. Plus, Deep, and Deep Plus sit at the lower end in fine lines, lips, and folds. Implant Plus sits at the higher end in cheeks, chin, and deep volume placements. Individual duration varies with tissue site, movement, and metabolism.

Is Dermalax® filler FDA approved?

No. Dermalax® is CE-marked but is not authorized by the FDA for use in the United States. Practitioners should confirm current regulatory status in their own market before ordering.

Is Dermalax® a good filler?

For the Korean HA segment it competes in, yes. It is CE-marked, hyaluronidase-reversible, backed by clinical evidence for its most common indication [2], and priced accessibly against European premium ranges.

Where can practitioners buy Dermalax® wholesale?

Licensed professionals can buy Dermalax® wholesale through Doctor Medica. The team supplies the full four-product range to licensed practitioners at wholesale, with LOT-traceable stock, verified authenticity, and shipping arranged with cold-chain-appropriate handling.

For licensed medical professionals only. This content is for informational purposes only and does not constitute medical advice.

Citations and Resources

[1] European Medicines Agency. “Meeting Highlights from the Pharmacovigilance Risk Assessment Committee (PRAC), 3–6 May 2021.” European Medicines Agency, 7 May 2021, www.ema.europa.eu/en/news/meeting-highlights-pharmacovigilance-risk-assessment-committee-prac-3-6-may-2021.

[2] Qiao, Ju et al. “The efficacy and safety of Dermalax^TM DEEP in the correction of moderate to severe nasolabial folds: a multicenter, randomized, double-blind clinical study.” The Journal of dermatological treatment vol. 32,5 (2021): 548-555. doi:10.1080/09546634.2019.1687814

[3] Faivre, Jimmy et al. “Crosslinking hyaluronic acid soft-tissue fillers: current status and perspectives from an industrial point of view.” Expert review of medical devices vol. 18,12 (2021): 1175-1187. doi:10.1080/17434440.2021.2014320

[4] Across Co., Ltd. “Botulinum Toxin Products.” Across, across.kr/eng/sub/sub02_06.php.

[5] U.S. Food and Drug Administration. “Dermal Fillers (Soft Tissue Fillers).” U.S. Food and Drug Administration, www.fda.gov/medical-devices/aesthetic-cosmetic-devices/dermal-fillers-soft-tissue-fillers.

Written by Doctor Medica’s Editorial team

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