HYAFILIA®

What Are HYAFILIA® Fillers?

HYAFILIA® is a line of high-quality hyaluronic acid (HA) dermal fillers, developed for safe and natural facial rejuvenation. Produced in South Korea, HYAFILIA® products are made from non-animal stabilized HA and are classified as medical devices designed to temporarily improve the appearance of wrinkles and restore facial volume. HYAFILIA® fillers are known for their clear, colorless, viscoelastic gel texture and optimal cross-linking, which delivers long-lasting results with a smooth, natural finish. The brand uses BDDE (1,4-butanediol diglycidyl ether) to stabilize HA, increasing its durability and effectiveness in tissue integration. Read our comprehensive article on the Hyafilia Manufacturer.

HYAFILIA® Product Range

The HYAFILIA® Plus line consists of advanced formulations with optimized particle sizes and enhanced flow characteristics. Two standout products include:

HYAFILIA® Grand Plus

• Type: Cross-linked HA filler
• Particle Size: ~1100 μm
• HA Concentration: 20 mg/ml
• Indications: Deep wrinkles, folds, and volume loss
• Injection Depth: Deep dermis or subcutaneous tissue
• Syringe Sizes: 1 ml, 2 ml, 3 ml (with 23G or 27G needles)

Grand Plus is ideal for:

• Nasolabial folds
• Marionette lines
• Chin, cheek, and jawline augmentation

HYAFILIA® Petite Plus

• Type: Cross-linked HA filler
• Particle Size: ~200 μm
• HA Concentration: 20 mg/ml
• Indications: Fine facial wrinkles and delicate areas
• Injection Depth: Superficial to mid dermis
• Syringe Sizes: 1 ml, 2 ml, 3 ml (with 27G or 29G needles)

Petite Plus is ideal for:

• Crow’s feet
• Forehead lines
• Perioral wrinkles
• Tear troughs

How Long Do HYAFILIA® Fillers Last?

HYAFILIA® fillers are designed to provide natural volume and wrinkle correction lasting up to 6 months, depending on:

• The patient’s metabolism
• Treated area
• Product type

In clinical observations, the residual volume and skin thickness were maintained consistently for 3–6 months after treatment. This mid-term duration makes HYAFILIA® suitable for routine aesthetic maintenance.

Indications of HYAFILIA®

HYAFILIA® is indicated for a wide range of aesthetic concerns:

• Correction of facial wrinkles and folds
• Restoration of lost volume
• Contouring of facial features
• Improving hydration and elasticity in aging skin

The filler types correspond to treatment depth:

• Petite Plus for delicate and superficial areas
• Grand Plus for deep volumizing and structural enhancement

HYAFILIA® Ingredients

Each HYAFILIA® filler contains:

• Cross-linked hyaluronic acid (non-animal origin)
• BDDE (cross-linking agent to increase longevity and stability)
• Sterile, pyrogen-free water for injection

The fillers are biocompatible, biodegradable, and iso-osmotic, ensuring safety and minimal risk of inflammatory response. No lidocaine is included, allowing practitioners to tailor pain management protocols independently.

HYAFILIA® Administration Technique

The administration technique varies by product and treatment goal:

HYAFILIA® Grand Plus:

• Needles: 23G or 27G
• Injection plane: Deep dermis or subcutaneous
• Volume: Usually 1–2 ml depending on area
• Method: Linear threading, fanning, or bolus for structural augmentation

HYAFILIA® Petite Plus:

• Needles: 27G or 29G
• Injection plane: Superficial to mid-dermis
• Method: Microdroplet, serial puncture, or linear threading for precision in fine lines

Practitioners are advised to adhere to aseptic technique and tailor the injection strategy to each patient’s anatomy and skin quality.

Contraindications and Side Effects

Contraindications:

• Known allergy or hypersensitivity to HA or BDDE
• Active skin infections at the injection site (e.g., acne, herpes)
• Pregnancy and breastfeeding
• Autoimmune disorders
• Bleeding disorders or use of anticoagulants

Side Effects:

• Mild, transient effects may include:
  • Swelling
  • Bruising
  • Tenderness
  • Redness
• Rare complications:
  • Lumps or nodules
  • Tyndall effect (if injected too superficially)
  • Vascular occlusion (with improper technique)

Clinical studies report no serious adverse events, and all observed effects were mild and self-resolving.

Storage Instructions

To maintain product efficacy and safety:

• Store at 1–30°C
• Avoid direct sunlight
• Do not freeze
• Keep in original sterile packaging until use

Shelf life is 36 months from the manufacturing date under proper storage conditions.

Who Manufactures HYAFILIA®?

HYAFILIA® is developed and manufactured in South Korea, under certified Good Manufacturing Practice (GMP) standards and ISO 13485 quality systems. The brand is associated with Korean biomedical innovation and trusted by aesthetic professionals globally. Manufacturing includes:

• High-purity HA synthesis
• Precision particle sizing via mesh filtration

Advanced cross-linking with minimal residual BDDE