RESTYLANE®

About Restylane® — Galderma’s HA Dermal Filler Range

Restylane® is manufactured and marketed by Galderma, headquartered in Zug, Switzerland,, and one of the largest dedicated aesthetics companies globally. The brand launched in Europe in 1996 as one of the first hyaluronic acid or HA dermal fillers available to practitioners, followed by its first FDA approval in the US market in 2003. Since then, the Restylane® family has been used in tens of millions of cosmetic treatments worldwide.

What is Restylane®? Who made Restylane®?

The family of injectable Restylane® dermal fillers are formulated differently depending on their intended treatment area and clinical purpose. Some are designed for firm structural lift, others for softer, more flexible support in areas with constant movement like the mouth. Galderma is the company behind the brand (the short answer to who makes Restylane®), and its products carry CE marking in Europe alongside multiple individual FDA approvals in the US. [1][2]

Restylane® Filler Technology — NASHA® and XpresHAn™

Two proprietary technologies underpin the range, and knowing which product relies on which one helps practitioners match formulation to indication.

• NASHA® Technology stands for Non-Animal Stabilized Hyaluronic Acid. It produces a firmer, more particulate gel with a defined degree of crosslinking, built for precision placement and structural support. NASHA® is the technology behind Restylane® LYFT, Restylane® EYELIGHT™, and the SKINBOOSTERS™ line, all products where a controlled lift or firm positioning matters more than flexibility. [3]
• XpresHAn Technology™, also referred to globally as OBT (Optimal Balance Technology), takes a different approach. It varies the degree of crosslinking to produce a softer gel that flexes and moves with surrounding tissue rather than resisting it. This is the technology behind Restylane® KYSSE, Restylane® DEFYNE, and Restylane® REFYNE, products designed for areas with significant natural movement such as the lips and the lower face. [4]

RESTYLANE® SKINBOOSTERS™ VITAL and VITAL LIGHT share the same NASHA® manufacturing heritage but are formulated as a finer, more fluid gel meant to disperse through the skin for hydration rather than sit in place for volume or structure.

Both core technologies start with HA produced through bacterial fermentation rather than animal extraction, which is part of why allergy skin testing is not required before treatment, as it was with older animal-derived fillers. And because every Restylane® injectable is HA-based, all of them can be dissolved with hyaluronidase if a correction or reversal is ever needed. That reversibility is a meaningful clinical safeguard across the entire range of Restylane® injectables. [3][4]

Restylane® Products — Full Range Overview

All ten products in the current Restylane® range are listed below. Each targets a specific indication or treatment area.

RESTYLANE® SKINBOOSTERS™ VITAL with Lidocaine is an HA skin booster built for deep hydration and general skin quality improvement. It is typically used on the face, neck, and hands across a series of sessions rather than a single visit.

RESTYLANE® 1ml with Lidocaine is the original Restylane® formula, still in use today for nasolabial folds, lip volume, and finer facial lines. It is the product that started the brand.

RESTYLANE® DEFYNE with Lidocaine uses XpresHAn Technology™ and is designed for deeper lines and folds where the goal is correction without losing natural facial movement. It also carries an FDA approval for chin augmentation. [5]

RESTYLANE® EYELIGHT™ was developed specifically for the tear trough and periorbital area, targeting under-eye hollowing and the dark shadowing that accompanies it. It uses NASHA® Technology in a 0.5 mL syringe format specifically branded and packaged for periorbital treatment. FDA clinical study data demonstrated effectiveness for up to 12 months. [1]

RESTYLANE® KYSSE with Lidocaine is Galderma’s dedicated lip filler. Built on XpresHAn Technology™, it is formulated to move naturally with the mouth rather than feel rigid, which is a large part of why Restylane® KYSSE lip filler has become the most requested lip product in the line.

RESTYLANE® LYFT uses NASHA® Technology and is positioned for cheek augmentation, midface volume restoration, and moderate-to-severe folds. It carries FDA approval for both cheek augmentation and correction of volume loss in the back of the hands, making it one of the more versatile Restylane® fillers in the range.

RESTYLANE® LYFT with Lidocaine is the same Restylane® LYFT dermal filler formulation with lidocaine included for improved patient comfort during injection.

RESTYLANE® REFYNE with Lidocaine is the softer counterpart to DEFYNE, also built on XpresHAn Technology™ and intended for moderate lines and folds where flexibility matters more than firm structure.

RESTYLANE® SKINBOOSTERS™ VITAL LIGHT with Lidocaine is a lighter version of the VITAL formula, suited to thinner or more delicate skin where a heavier Restylane® skinbooster product would be excessive.

RESTYLANE® VOLYME with Lidocaine is a deeper volumizing filler aimed at cheek and midface augmentation, delivering pronounced fullness and volume for patients presenting with significant age-related volume deficit.

Treatment Areas and Clinical Indications for Restylane® Injectables

• Lips: Restylane® KYSSE is the primary option for lip enhancement Restylane® practitioners reach for, purpose-built for Restylane® lip injections and designed to hold up under constant oral movement. Restylane® Silk was the first product specifically approved for subtle lip augmentation and smoothing of fine perioral lines, and remains a good option for patients who want a more understated result. Restylane® 1ml is a reasonable alternative for subtler volume additions as well. Together these cover most of what is needed for Restylane® lip filler applications, whether the goal is fullness, definition, or softening perioral lines. The clinical data behind KYSSE, including its up-to-12-month duration, makes a strong case for its effectiveness.
• Cheeks and midface: LYFT and VOLYME handle the heavier volumizing work, restoring fullness and volume in patients with age-related midface flattening. Restylane® cheek filler options are among the best-supported in the HA filler category. Practitioners also use Restylane® LYFT along the jawline off-label, though it is worth noting that Restylane® DEFYNE, not LYFT, holds the FDA approval for chin augmentation. [5] Fillers restore a youthful appearance in this zone particularly well because the midface is where volume loss first becomes visible.
• Under-eye: One of the Restylane® injections under eyes is EYELIGHT™, which addresses hollowing and the dark shadowing that often accompanies periorbital volume loss.
• Lines and folds: DEFYNE and REFYNE cover moderate to severe facial wrinkles and folds. Restylane® DEFYNE handles deeper lines and wrinkles, while Restylane® REFYNE suits moderate lines and wrinkles where preserving natural expression is the priority. Restylane® for wrinkles is one of the more common reasons practitioners build their inventory around this brand. Restylane® contour work in the chin area is also covered by DEFYNE’s FDA-approved chin augmentation indication. Restylane® before and after results in this area tend to show meaningful improvement in fold depth with natural expression maintained.
• Skin quality: SKINBOOSTERS™ VITAL and VITAL LIGHT focus on skin hydration, quality, and elasticity rather than volume, useful for patients whose primary concern is skin texture and radiance rather than reshaping facial features.

How Long Does Restylane® Last?

Duration varies by product and treatment area, which is something worth discussing during consultations. LYFT and VOLYME in the cheeks and midface typically last 12 to 18 months. KYSSE in the lips has shown results lasting up to 12 months in FDA clinical trial data, a longer duration than many practitioners associate with lip fillers given how actively the area moves. DEFYNE and REFYNE in the folds generally last 9 to 12 months. EYELIGHT™ under the eyes has demonstrated effectiveness for up to 12 months in clinical study data. SKINBOOSTERS™ results last around 6 months with maintenance sessions to sustain the effect. How long will Restylane® last in any individual case depends on metabolism, injection technique, and product placement.

As for whether Restylane® migrates, the risk is low when the product is placed correctly. The XpresHAn™ products in particular are designed to integrate with surrounding tissue and move with it rather than shift out of position.

Restylane® Compared to Other HA Fillers

Several other HA filler brands compete with Restylane® across overlapping indications. The differences come down to crosslinking technology, gel consistency, regulatory footprint, and range depth. Below is how Restylane® stacks up against the five most commonly compared alternatives available through Doctor Medica.

vs JUVÉDERM®

Restylane® comes from Galderma, JUVÉDERM® from AbbVie, and the two rely on fundamentally different crosslinking approaches. JUVÉDERM® uses VYCROSS® or HYLACROSS™ technology, which produces a more cohesive, monophasic gel that many practitioners find smooth for lips and superficial lines. Restylane® leans on NASHA® or XpresHAn™ crosslinking instead, producing a gel that is either more particulate and structural or more flexible and dynamic depending on the product. Both brands last roughly 6 to 18 months depending on the specific formulation, and both are reversible with hyaluronidase. The clearest differentiator is that Restylane®’s XpresHAn™ line was purpose-built to move with facial expressions, which matters most in Restylane® for lips and other high-movement areas. Restylane® vs JUVÉDERM® is one of the most common comparisons practitioners encounter, and neither brand is categorically superior; the choice depends on indication and injector preference.

vs BELOTERO®

BELOTERO®, made by Merz, uses Cohesive Polydensified Matrix (CPM) technology. This creates a very soft, highly cohesive gel that blends into tissue particularly well for fine superficial lines, an area where it often outperforms Restylane® 1ml. Restylane®’s advantage runs the other direction: a ten-product range covering volumizing, contouring, lips, and skin quality far more comprehensively than BELOTERO®’s current portfolio, and a dedicated lip product (KYSSE) with a clinical data set BELOTERO® does not currently match. Both are HA-based and reversible. Duration is broadly comparable across the two brands.

vs TEOSYAL®

TEOSYAL®, from Teoxane in Switzerland, uses patented RHA® (Resilient Hyaluronic Acid) technology, engineered so the gel withstands repeated facial movement more effectively. This is a similar clinical goal to what XpresHAn™ accomplishes for Restylane®. TEOSYAL® REDENSITY I competes directly with Restylane® SKINBOOSTERS™ in the skin quality space, and TEOSYAL® has a strong European clinical evidence base overall. Restylane®’s edge is regulatory breadth: LYFT’s FDA approval for both cheeks and hands gives it a more extensive US market presence than TEOSYAL® currently holds. Both are reversible with hyaluronidase.

vs REVANESSE®

REVANESSE®, made by Prollenium in Canada, is known for a very pure formulation and a reputation for lower post-treatment swelling, a tolerability claim backed by clinical data. REVANESSE® LIPS+ goes head-to-head with Restylane® KYSSE in the lip filler category. Where Restylane® pulls ahead is depth of range: ten products against REVANESSE®’s smaller lineup, along with broader CE and FDA approvals. REVANESSE® tends to be priced competitively, and both brands are reversible.

vs STYLAGE®

STYLAGE®, from Laboratoires VIVACY in France, uses IPN-Like (Interpenetrating Network) crosslinking with mannitol included as an antioxidant. The mannitol is intended to reduce post-injection swelling and extend product longevity by neutralizing free radicals at the injection site, a specific differentiator that Restylane® products do not currently include. STYLAGE® holds its own in facial volumizing and lip augmentation, but Restylane® retains the deeper global regulatory footprint, including its US FDA approvals, and STYLAGE® does not have a direct equivalent to Restylane® SKINBOOSTERS™ or the XpresHAn™ dynamic-expression line. Both are reversible with hyaluronidase.

Clinical Benefits of Restylane® for Aesthetic Practitioners

A ten-product range under one brand gives a practice a full-face protocol without needing to source from multiple manufacturers. Lips, cheeks, folds, under-eye correction, and skin quality are all covered, which simplifies inventory and training for clinical teams.

The dual-technology approach adds a layer of precision on top of that breadth. NASHA® handles the structural, high-lift indications, while XpresHAn™ covers areas that need to keep moving naturally after treatment. That split lets practitioners match product to indication with specificity rather than stretching one formulation into a role it was not built for.

Some clinics begin with KYSSE and LYFT as their two highest-demand Restylane® treatments and build outward from there, adding DEFYNE for fold work and EYELIGHT™ as their under-eye cases grow. The modularity of the line makes that kind of gradual adoption straightforward, and it tends to improve case consistency when the same technology family is used across a full treatment plan.

Regulatory depth matters in this category as well. Restylane® carries CE marking and multiple individual FDA approvals across its range, giving it one of the strongest overall regulatory footprints among HA filler brands.

Regulatory Status – Where to Purchase Restylane®

Restylane® is CE-marked for the European and UK markets. In the US, individual FDA approvals cover LYFT (cheeks and hands), KYSSE (lips), DEFYNE (folds and Restylane® chin filler augmentation), and REFYNE (folds), among other Restylane® injections in the range. [1][2][5] Galderma manufactures the line to ISO standards. As with any HA filler, Restylane® can be dissolved with hyaluronidase, though this is generally considered an off-label use of hyaluronidase in most markets rather than a formally labeled indication.

As with any HA filler, Restylane® can be dissolved with hyaluronidase, though this is generally considered an off-label use of hyaluronidase in most markets rather than a formally labeled indication.

Side Effects and Safety

Common side effects of Restylane® injections include bruising, swelling, and tenderness at the injection site, all typically transient and resolving within days. Rarer complications include vascular occlusion, which is technique-dependent and underscores the importance of advanced injection training, and nodule formation. Potential risks should be discussed with every patient before treatment, and standard filler consent documentation should be part of every session regardless of how routine the procedure feels. These considerations apply equally to Restylane® and to other aesthetic and plastic surgery injectable procedures.

Buy Restylane® Wholesale — Doctor Medica

Buy Restylane® from Doctor Medica today. Browse the full catalogue above or contact our team directly for wholesale pricing on any product in the range. We supply licensed practitioners with verified Galderma products and handle shipping to clinics across a wide range of markets. Practitioners looking to order Restylane® online will find the process straightforward: select your products, confirm quantities, and our team will provide a quote. We can walk you through product selection if you are building a Restylane® filler kit for a new practice or expanding an existing one.

Restylane® cost varies by product and order volume. Practitioners who buy Restylane® wholesale in larger quantities can often take advantage of better per-unit pricing. Reach out for a quote specific to what your practice needs, whether that is a single case of KYSSE or a full-range order. You can also purchase Restylane® online through our website for a streamlined ordering experience with reliable shipping timelines.

Frequently Asked Questions

What is Restylane® used for?

Restylane® covers most facial aesthetic indications: lip enhancement (KYSSE), cheek and midface volume (LYFT, VOLYME), nasolabial folds (DEFYNE, REFYNE), under-eye hollows (EYELIGHT™), fine lines (Restylane® 1ml), and skin hydration (SKINBOOSTERS™).

Who makes Restylane®?

Galderma, a global dermatology and aesthetics company headquartered in Zug, Switzerland, manufactures and markets the entire Restylane® range. Galderma is one of the largest HA filler manufacturers in the world.

How long does Restylane® last?

Results last 6 to 18 months depending on the product and treatment area. LYFT and VOLYME in the cheeks can last up to 18 months. KYSSE in the lips has demonstrated results lasting up to 12 months. SKINBOOSTERS™ results last around 6 months with a maintenance schedule.

Can Restylane® be removed?

All Restylane® products are hyaluronic acid-based and can be dissolved with hyaluronidase. Migration risk is low when the product is placed correctly, and XpresHAn™ products are specifically engineered to integrate with tissue movement.

Is Restylane® safe?

Restylane® has a well-established safety profile. Several products hold both CE marking and FDA approval. Common reactions include temporary bruising, swelling, and tenderness. Rare risks include vascular occlusion, which is technique-dependent.

What is the difference between Restylane® and JUVÉDERM®?

They use different crosslinking technologies: Restylane® relies on NASHA® and XpresHAn Technology™, while JUVÉDERM® uses VYCROSS® and HYLACROSS™. Restylane®’s XpresHAn™ fillers are designed for natural movement in dynamic facial areas. Both brands are CE-marked and FDA-approved across multiple products.

Where can practitioners buy Restylane® wholesale?

Licensed practitioners can buy Restylane® wholesale through Doctor Medica. Browse the Restylane® catalogue or contact Doctor Medica’s staff for product availability, wholesale pricing, and shipping details.

For licensed medical professionals only. This content is for informational purposes only and does not constitute medical advice.

Citations and Resources

[1] Galderma. “Galderma Receives FDA Approval for Its Newest Hyaluronic Acid Filler, Restylane® Eyelight™.” Galderma, 5 June 2023.

[2] Galderma. “Galderma Receives FDA Approval for Restylane® Kysse, a New Hyaluronic Acid (HA) Filler Specifically Designed and Indicated to Add Fullness to the Lips and Help Smooth the Wrinkles Above the Mouth.” Galderma, 6 May 2020.

[3] Galderma. “Restylane® Science & Technology.” Restylane USA, www.restylaneusa.com/restylane-science.

[4] Galderma. “Galderma Announces FDA Approval of Restylane® Refyne and Restylane® Defyne Dermal Fillers for Treatment of ‘Laugh Lines.’” Galderma US, 12 Dec. 2016, www.galderma.com/us/news/galderma-announces-fda-approval-restylane-refyne-and-restylane-defyne-dermal-fillers.

[5] Galderma. “Galderma Receives FDA Approval for Restylane® Defyne for Chin Augmentation.” Galderma, 4 Feb. 2021, www.galderma.com/news/galderma-receives-fda-approval-restylaner-defyne-chin-augmentation.

Written by Doctor Medica’s Editorial team

The content on this page has been written and fact-checked in accordance with our Editorial Policy. Clinical claims are sourced from peer-reviewed literature, regulatory documentation, and manufacturer specifications. Where citations are provided, it is always in accordance to our editorial standards.