Comparison of Saypha and Radiesse Dermal Fillers

Skin care


Last Updated On: 2024-01-13

To help you select the best fillers for the job, we offer dermal fillers comparison for Saypha and Radiesse. Learn what these brands can do for your patients.

Doctor Medica team

Please be aware that the described products are intended for use by only medical professionals qualified in filler injections and have allocated clinical settings for the procedure. If performed by non-professionals in non-clinical, non-sterile, or other unsafe settings, the injections can cause serious damage to your health.

The current abundance of products for aesthetic treatments can confuse even the most experienced physician or plastic surgeon. If we tackle the hot topic of dermal fillers, new varieties regularly hit the market and position themselves as novelties. 

However, the difference between the new and older versions can be minimal. Different brands can manufacture similar fillers and offer them as something exceptional, thus making the selection process even harder.

To help you stay informed about the filler market, we provide this dermal fillers comparison for products created by brands Saypha and Radiesse. The article will cover the composition, main functions, areas of intended use, and other essential features of these fillers. 

The comparison will let you pick the dermal fillers that are most suitable for your patient’s needs and that will help them look attractive, hot, and youthful again.

Saypha Dermal Fillers Overview

Saypha is a brand name adopted in 2019 by the already-known and popular filler brand Princess (manufactured by the Austrian company Croma-Pharma GmbH). Remember this naming change if you plan to buy the Princess brand, as you can confidently buy Saypha products instead.

The most common characteristic of Saypha fillers is that they are made of sterile hypoallergenic non-animal hyaluronic acid. 

Hyaluronic acid is a polysaccharides-based substance naturally produced by the human body and responsible for the lubrication, hydration and cushioning of sensitive tissues. When it’s level decreases in the body, tissues shrink, wrinkles and folds appear, and the aging process becomes evident.

All these fillers (except Saypha Rich) are cross-linked through the special S.M.A.R.T. technology (Supreme Monophasic and Reticular Technology). 

The resulting products are gels with excellent elasticity and smoothness, fit for use in superficial and deep layers of skin, and carefully controlled and certified for medical quality. 

They replenish the level of hyaluronic acid, fill shallow and deep lines, and help the skin return to its normal fresh, plump condition.

Specialized Fillers By Saypha And Their Key Characteristics

The Saypha line includes several fillers intended for various facial areas. All products in the line are medically certified for safety and quality.

Since they are made of hyaluronic acid, the side effects are mild and will recede soon. They can include redness, mild pain, swelling, itchiness, and minor discomfort. 

Hyaluronic acid is a natural human body component, so adverse health effects like severe irritation, allergies, or vessel clogging are rare.

SAYPHA FILLER With Lidocaine

This gel is universal in its application. Cross-linked to 2/4 level, it can be injected into medium-depth and deep tissues, and lidocaine provides greater comfort during treatment. 

Buy Saypha online for:

  1. Correcting moderate and deep facial wrinkles, folds, and lines on cheeks, chin, and perioral area (marionette lines) 
  2. For reconstructing tissues with scarring, with areas of facial lipoatrophy, with deep cavities
  3. For fixing asymmetrical facial shapes
  4. For adding volume to lips and for improving their shape. The latter is an essential consideration since only SAYPHA FILLER and SAYPHA FILLER with lidocaine are officially approved for injecting into lips
  5. The implant can last up to 9 months.


This filler is universal and applicable for different facial areas but does not have lidocaine in its formula. The depth of injections is mid-to-deep skin layers. It can be injected into the following: 

  1. Facial cavities
  2. Cheeks, chin, cheekbones
  3. Nasolabial lines and marionette lines
  4. Lips
  5. Scarred areas and areas with loss of facial fatCross-linking level: 2/4
  6. Longevity: up to 9 months.


The high thickness and durability make this filler suitable for: 

  1. Injection into severe wrinkles and folds
  2. Contouring the face
  3. Restoring lost facial volume in middle parts
  4. Filling unwanted cavities
  5. Cross-linking level: 4/4
  6. Longevity: between 6 and 12 months
  7. Added lidocaine accounts for a painless procedure.

SAYPHA VOLUME With Lidocaine

With added lidocaine and a level of cross-linking 3/4, the thick gel keeps its shape well after injection. It is suitable for injecting into:

  1. Cheekbones and chin for contour correction
  2. Cheeks and cavities for filling the hollowness
  3. Deep wrinkles like marionette wrinkles
  4. Areas with absent facial fat
  5. Cross-linking level: 3/4
  6. Longevity: 9 months.


This filler is similar to SAYPHA VOLUME with lidocaine but does not have an anesthetic in its formula. You should consider buying the Saypha filler gel of higher density for:

  1. Cheekbones and chin for contour correction
  2. Cheeks, cavities, temple hollows
  3. Deep wrinkles like marionette wrinkles and nasolabial folds
  4. Areas lacking facial fat
  5. Cross-linking level: 3/4
  6. Longevity: minimum nine months.


In this non-cross-linked filler, hyaluronic acid is stabilized by glycerol. The thin gel is intended for filling fine lines and mesotherapy that replenishes moisture in skin layers and returns it to its natural glow and younger look. The filler is:

  1. Injected superficially
  2. Intended for fine lines like crow’s feet or smoking lines around the mouth
  3. Boosts elasticity and evenness of skin tone
  4. Three sessions of therapy may be needed at 3-week intervals
  5. Longevity: up to 6 months

Radiesse Dermal Fillers Overview

Radiesse is a line of fillers of a different type, developed and manufactured by Merz Aesthetics, the global medical company with headquarters in Germany. 

Decades of manufacturing experience and sophisticated research allowed the company to create dermal fillers based on synthetic calcium hydroxylapatite, which accounts for the longevity of effect and unique ability of fillers to trigger the production of collagen in the human body. 

When injected into tissues, the liquid component of filler plumps the treated areas immediately, and calcium hydroxylapatite microspheres start degrading slowly. 

Released elements signal the body to begin producing protective and healing substances, and the injection area is gradually filled with naturally produced collagen, firm and long-lasting. 

This means you can buy Radiesse filler online to fill relatively big areas or cavities on the face and hands. 

Specialized Fillers By Radiesse And Their Key Characteristics

All fillers in this range are made up to the strictest medical standards and approved and certified by international institutions responsible for medical supplies safety, including FDA.

Since the fillers contain hard particles, they can cause mild irritation, swelling, dermatitis, or inflammation a few days after injection. Anti-inflammatory treatment is recommended in this case. 

Formation of nodules in tissues can occur due to improper injection or aftercare. This adverse effect should be treated in clinical settings.  

When you plan to purchase Radiesse products, remember that standard precautions related to all Radiesse fillers are: 

  1. They should not be injected into the glabella area (because blood vessel clogging may occur).
  2. They should be injected into deep tissues; superficial injection is not recommended.


Composition: calcium hydroxylapatite (CaHa), sodium carboxymethyl cellulose, glycerin, water.

Intended areas of treatment: Buy Radiesse 1.5 ml if you need to treat moderate and deep folds and wrinkles on the face, scars, and pits from acne, uneven skin on the nose and chin, and hollow temples. The filler can be injected to contour the jaw, chin, and cheeks; it performs well when used for cavities on aging hands. 

Longevity: 18 months or longer (for collagen implant naturally created by the human body).

RADIESSE (+) 1.5 ml with lidocaine

Composition: calcium hydroxylapatite (CaHa), sodium carboxymethyl cellulose, glycerin, water, lidocaine.

Intended areas of treatment: moderate and deep folds and wrinkles on the face, acne scars and indentations, uneven skin, and bumps on the nose and chin. The filler can be injected to contour the jaw, chin, and cheeks; to fill temple cavities. It shows promising results in treating aging hands. 

Longevity: 18 months or longer (for collagen implant).


Composition: calcium hydroxylapatite (CaHa), sodium carboxymethyl cellulose, glycerin, water.

Intended areas of treatment: moderate and deep folds and wrinkles on the face, scarring from acne and blemishes, and uneven skin on the nose and chin. The filler can be injected to contour the jaw, chin, and cheeks; purchase it if your patients want to fill cavities on aging hands and temples. 

Longevity: 18 months or longer (for collagen implant).

RADIESSE (+) 0.8 ml with lidocaine

Composition: calcium hydroxylapatite (CaHa), sodium carboxymethyl cellulose, glycerin, water, lidocaine.

Intended areas of treatment: moderate and deep folds and wrinkles on the face, acne scars and indentations, uneven skin, and bumps on the nose and chin. The filler can be injected to contour the jaw, chin, and cheeks; it shows good results in treating aging hands and is suitable for temples and other facial cavities. 

Longevity: 18 months or longer (for collagen implant).

Comparison of Saypha and Radiesse Fillers Lines

Both reviewed filler brands are good in their own way. As a responsible dermal fillers supplier, we will outline particularities to consider.

Similarities Shared By Fillers

  1. Both brands are made of substances naturally occurring in the human body and are biocompatible and biodegradable.
  2. Both brands can be safely injected into facial parts and skin and décolletage for filling wrinkles, smoothing skin unevenness, filling cavities and indentations, contouring, and gentle face sculpting.
  3. They can have lidocaine in their formula for a better injecting experience.

Differences Among Fillers 

Although similar in some aspects, Saypha and Radiesse have their distinctive features: 

  1. Saypha filler can be injected into lips and glabella area, while Radiesse is not recommended for it yet can be injected into the backs of the hands
  2. Saypha line is made of hyaluronic acid, and Radiesse – of calcium microspheres suspended in the liquid
  3. Saypha products have various degrees of density, and viscosity
  4. Saypha fillers last up to 9 months, while Radiesse lasts up to 18 months
  5. Radiesse fillers start the production of collagen in the body, while Saypha fillers do not.

Efficacy and Safety Overview

Regarding safety and efficiency, both filler brands live up to high expectations and do what they are expected to. Patients report improvements in skin, facial shape, and plumpness and have no complaints about side effects.

Both brands manufacture their fillers according to strict medical standards and put them through the international approval process. You can buy dermal fillers online from us confidently.

Tips on Choosing the Appropriate Dermal Filler For The Task

Technically speaking, it’s a matter of preference what filler to inject since both are efficient; however, there are fine distinctions to consider. 

Saypha fillers, with their varying thinness and fluidity, can be injected to treat fine lines, lips, and glabella areas. They can be injected superficially and into mid and deep layers of skin. 

Hyaluronic acid that makes up the filler also provides the hydrating effect. Skin and tissues, after treatment, retain their softness and mobility.

Buy Radiesse online to fill larger areas and hollows, as it creates a firm implant, a frame to support tissues. It keeps shape perfectly and is excellent for contouring and shaping facial parts like cheekbones. The tissues become relatively denser, which is OK for areas that are not very mobile and flexible.

Besides, if hyaluronic acid is neutral and usually does not cause allergies, then Radiesse is made of substances that can trigger allergies in some patients.

Treatment And Post-Treatment Recommendations

When you choose a filler type, it is crucial to observe the required procedures before and after treatment to ensure optimal results and reduce the risk of adverse effects.

Preparation and Injection technique for Saypha and Radiesse 

The preparation step is similar for both fillers: 

  1. Disinfect the treatment area
  2. Assemble the syringe and the needle
  3. Push out all the air from the syringeInject
  4. Gently massage or smooth the filler under the skin to distribute it evenly, without lumps
  5. If the gel remains in the syringe, discard it.

The injection steps differentiate because of the properties and consistency of fillers. 

Radiesse is to be injected into deep layers of skin or muscles, the needles being at 30 degrees angle to the skin surface. The filler is deposited in parallel lines in tissues to avoid clotting and lumping. 

Thin Saypha fillers can be injected superficially in directions required by the desired results. 

Dense Saypha fillers are to be deposited in mid and deep layers of tissues. If a cavity is filled, the gel is injected till the desired results. For smoothing lines and small indentations, inject the gel in tiny portions to control the outcome. 

When used to augment lips, the filler must be injected according to the lip anatomy and desired effect (cherry lips, plumping, tenting, contouring, etc.).

Aftercare For Better Results And Lower Risks Of Complications

After injections, patients should avoid hot environments, baths, and beaches for 24 hours. It is advisable to sleep on one’s back and to skip the facial massage and intensive physical training in the first 24 hours to avoid misplacement or deformation of an implant. 

Downtime is usually not required; an ice pack can be used to reduce discomfort immediately after the injection.

Results and Patient Satisfaction delivered by Saypha and Radiesse

All fillers as cosmetic products were initially designed to fill wrinkles and unwanted cavities and to plump and refill dehydrated skin. Another goal was to improve the shape of cheeks, chin, cheekbones, and lips, thus making people look younger, fresher, and more beautiful. 

Both Saypha and Radiesse are expected to provide this effect of augmentation and rejuvenation of the face and décolletage, making contours more defined, skin plumper, and lips juicier. In addition, Radiesse should help fill cavities on the backs of the hands that appear with age.

Patient Satisfaction in Numbers

Ultimately, the primary outcome in treatment is not the filler longevity as such or specific processes happening in the body but how patients feel about themselves and if they are happy with what they see in the mirror. 

When the patients’ feedback is taken into consideration, the performance of Saypha and Radiesse is close to perfection.  

Saypha: 98% of patients who had injections into facial parts and lips are satisfied with the results and will repeat the procedure.

Radiesse: 97% of patients who got treatment for facial wrinkles and hands are happy with the outcomes and will get a maintenance treatment.

Comparison Of Actual Outcomes, According To Patients

As the results show, both types of fillers perform exceptionally well. They both cope with the task of dermal filling and rejuvenation. Saypha is also great at plumping lips, and Radiesse provides defined and long-lasting contours to the face, making it look younger and healthier. 

The longevity of results was also as promised, according to the patients’ reports.


The reviewed fillers belong to top-class products that are safe, tested, and very effective in filling wrinkles, hollows, and imperfections. They last longer, do not cause discomfort when injected properly, and help patients feel younger and prettier again. 

Pick the specific gel for particular tasks from any described brands, and the treatment results will leave your patients happy.



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