Monovisc Generic Name – About Sodium Hyaluronate

A relevant study published in Orthopedic Reviews found that viscosupplementation with sodium hyaluronate significantly reduces knee pain and improves function in patients with osteoarthritis. This finding underscores the importance and effectiveness of sodium hyaluronate in treating joint-related issues, providing a non-surgical option for pain relief and enhanced mobility.

Monovisc, a leading product in this category, utilizes sodium hyaluronate as its active ingredient. It is specifically designed for patients suffering from knee osteoarthritis who have not found sufficient relief from conservative treatments. Monovisc offers a single-injection regimen to lubricate and cushion the knee joint, thereby reducing pain and improving joint function.

This article will explore the science behind sodium hyaluronate, uncover Monovisc’s unique properties, and discuss its benefits and potential risks. 

Key Takeaways

• Sodium hyaluronate is the active ingredient in Monovisc, a viscosupplement used to treat knee osteoarthritis.
• It is a natural substance found in the body, crucial for joint health and function.
• Sodium hyaluronate works by lubricating and cushioning the joints, relieving osteoarthritis symptoms.
• Clinical trials have demonstrated the efficacy and safety of sodium hyaluronate in treating knee osteoarthritis.

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What is Sodium Hyaluronate?

Sodium hyaluronate is the sodium salt form of hyaluronic acid, a natural substance found in the human body. Its main job is to hold water and keep tissues well-lubricated, making it valuable in medical and cosmetic applications due to its exceptional moisture-retaining properties.

In the human body, sodium hyaluronate provides essential cushioning, which is crucial for maintaining joint health. It is widely used in treatments such as injectable fillers for skin hydration, eye drops, wound healing, and reducing wrinkles.

Sodium hyaluronate is abundantly present in the synovial fluid within our joints, where it acts as a lubricant and shock absorber, ensuring smooth and pain-free movement. Its natural presence in connective tissues underscores its critical role in keeping joints and eyes healthy.

Pharmacological Properties of Sodium Hyaluronate

Sodium hyaluronate is a large molecule with a molecular weight ranging from 1 to 2.9 million Daltons. This substantial size contributes to its effectiveness in joint lubrication and cushioning. Its structure resembles a coiled spring—flexible yet sturdy—making it ideal for absorbing shocks and ensuring smooth joint movement.

The magic of sodium hyaluronate extends beyond its size. As a viscoelastic substance, it balances viscous and elastic properties to cushion when your knee bends or twists. This balance is crucial for joint health, helping to reduce pain and improve joint function.

In the body, sodium hyaluronate is a lubricant and shock absorber for joints. It helps maintain healthy joints by regulating the breakdown and creation of new hyaluronic acid, ensuring optimal joint function. Attracting water forms a thick, slippery fluid that acts like oil in an engine, allowing bones to glide over each other without pain.

Sodium Hyaluronate in Osteoarthritis Treatment

Monovisc received FDA approval as a knee osteoarthritis treatment after promising results in a pivotal phase III clinical trial involving 369 patients.

The results were precise—those treated with Monovisc reported better pain relief at 12 weeks compared to those who didn’t get this treatment. What stands out is how safely it works; the study pointed out a meager rate of adverse events, and no adverse severe issues arose.

Treatment	Efficacy	Adverse Events Rate	Remarks
Monovisc	Significant improvement in pain score at 12 weeks	Extremely low, with no serious adverse events reported	Benefits from sodium hyaluronate’s role in lubricating joints
Control Group (Placebo)	Lesser improvement compared to Monovisc	N/A	Highlights Monovisc’s effectiveness
Licofelone (Merckle and EuroAlliance partners)	Under investigation	N/A	Represents potential future competition

Formulation of Monovisc and Sodium Hyaluronate

Osteoarthritis affects over 10 million people in the US alone, underscoring the need for effective treatments like Monovisc. Notably, it is the first FDA-approved single injection explicitly designed for knee osteoarthritis, offering a groundbreaking approach to managing this widespread condition.

Monovisc consists of sodium hyaluronate, a key ingredient central to its effectiveness in treating knee osteoarthritis. This ingredient is derived from Anika Therapeutics’ innovative hyaluronic acid (HA) technology.

Monovisc’s prescribing information highlights its unique formulation, which includes partially cross-linked sodium hyaluronate (NaHA) that provides long-lasting relief from joint pain. Each pre-filled syringe delivers 88 mg of hyaluronan in a 22 mg/mL concentration, ensuring that patients receive a high molecular weight solution that targets pain directly at its source.

This concentration offers immediate and enduring benefits, making Monovisc an optimal choice for those seeking relief from the chronic discomfort associated with osteoarthritis.

Conclusion

Sodium hyaluronate, tucked inside Monovisc, relieves knee-deep osteoarthritis pain. It’s like a science-backed balm straight from nature—easing stiff joints without missing a beat.

With its FDA nod, this injection is not just another option but a beacon of hope for smoother moves and happier knees. Doctors have this tool ready for that sweet spot of comfort and mobility.

So here are the steps taken with ease and the lives lived fuller – all thanks to the wonders packed in each shot of Monovisc!

FAQs

1. What’s the generic name for Monovisc?

The generic name for Monovisc is Sodium Hyaluronate.

2. Can you tell me more about Sodium Hyaluronate?

Sodium hyaluronate is a naturally occurring substance in the human body. It’s used in medicine because it can bind large amounts of water.

3. How does Sodium Hyaluronate work as a medication?

Sodium Hyaluronate acts like a lubricant and shock absorber in the joints that have lost their natural cushioning due to conditions like osteoarthritis.

4. Is there any specific use of Monovisc or Sodium Hyaluronate?

Yes, Monovisc or Sodium Hyaluronate is often used as an injectable treatment for knee pain caused by osteoarthritis when other treatments have not worked.

References

Peck J, Slovek A, Miro P, et al. A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthopedic Reviews. 2021;13(2). doi:10.52965/001c.25549

WebMD. (n.d.). Sodium hyaluronate (intra-articular) – Uses, side effects, and more. Retrieved from https://www.webmd.com/drugs/2/drug-4037/sodium-hyaluronate-intra-articular/details

RXList. (n.d.). Monovisc (sodium hyaluronate) drug. Retrieved from https://www.rxlist.com/monovisc-drug.htm