LIPORASE® (Hyaluronidase) 1500U

LIPORASE® is a hyaluronidase-based injectable enzyme used in aesthetic and medical applications to dissolve hyaluronic acid-based fillers, enhance lipolytic injections, and treat post-procedural complications such as edema, fibrosis, or unwanted dermal deposits. Manufactured by Maypharm, LIPORASE acts by breaking down hyaluronic acid polymers, accelerating their absorption and removal from the body. It is commonly used to correct overfilled or misplaced dermal fillers, treat Tyndall effect, or improve fat-dissolving injections’ diffusion. LIPORASE is valued for its rapid action, high efficacy, and compatibility with lidocaine and saline-based formulations, making it a reliable agent for both emergency filler corrections and elective body contouring enhancement.

• Type: Injectable enzyme (hyaluronidase)
• Primary Use: Dissolving HA fillers, enhancing lipolytic injections
• Onset: Filler breakdown begins within hours of injection
• Applications: Aesthetic medicine, corrective treatments

LIPORASE is mixed with saline (and optionally lidocaine) before being injected into the target site. Administration protocols differ slightly depending on whether the target is hyaluronic acid filler or a fat-dissolving cocktail.

• For Filler Dissolution:
  • Mix 1 vial with 3 cc saline
  • Can dissolve approximately 3 cc of HA filler
  • Inject directly into the area of undesired filler
  • Filler begins to break down immediately and is absorbed within hours
• For Lipolysis Support:
  • Mix 1 vial with 5 cc saline for 10 cc lipodissolving solution
  • Use 2 vials for a 30 cc cocktail
  • Inject evenly into subcutaneous fat with lidocaine
  • Post-treatment: massage area for 15 minutes daily for 7 days, apply hot compress

LIPORASE is indicated for corrective aesthetic procedures and enhancement of fat reduction treatments.

Indications:

• Dissolution of hyaluronic acid dermal fillers
• Correction of overfilling, asymmetry, or Tyndall effect
• Treatment of granulomas, unhealthy edema, fibrosis, or post-lipolysis side effects
• Support in lipodissolving V-line injections
• Pre-surgical tissue conditioning

Contraindications:

• Known hypersensitivity to hyaluronidase
• Current infection or inflammation at injection site
• Pregnancy or breastfeeding (use with caution)
• Use in conjunction with non-HA fillers is not recommended

Side Effects:

• Mild redness, swelling, or bruising at injection site
• Rare allergic reactions (rash, itchiness)
• Overcorrection if too much filler is dissolved

LIPORASE contains purified hyaluronidase, an enzyme capable of hydrolyzing hyaluronic acid into smaller, absorbable fragments.

• Active Ingredient: Hyaluronidase (exact IU not always disclosed; dosage follows local guidelines)
• Form: Freeze-dried powder for reconstitution
• Reconstitution: Mix with sterile saline or lidocaine as required

LIPORASE is packaged in sterile vials, each formulated for single use after reconstitution.

• Package Includes:
  • 1 x vial of LIPORASE hyaluronidase (lyophilized powder)
• Packaging Type: Glass vial in a protective box
• Sterility: Sterile until opened and reconstituted

LIPORASE is generally safe when used properly but may result in localized or systemic reactions in sensitive individuals.

• Mild Effects:
  • Temporary redness, swelling, or bruising
  • Tingling or discomfort at injection site
• Moderate Effects:
  • Uneven volume loss or overcorrection
  • Short-term allergic reactions (itching, rash)
• Rare/Severe Effects:
  • Anaphylactic reactions (extremely rare)
  • Tissue damage if used improperly

To maintain potency and sterility, LIPORASE must be stored in controlled conditions both before and after reconstitution.

• Storage (Unopened): 2–25°C (do not freeze)
• After Reconstitution: Use immediately; discard unused solution
• Protection: Store away from moisture, light, and heat
• Shelf Life: Refer to expiration date on vial packaging