
Viscosupplementation, a treatment for knee osteoarthritis, has been systematically reviewed for its effectiveness and safety, revealing its potential in managing pain and functional decline in patients. Studies suggest that with over 5.5 million physician visits annually for osteoarthritis-related treatment in the United States alone, options like viscosupplementation are increasingly critical.
Cingal, a next-generation viscosupplementation product, combines hyaluronic acid with a steroid to provide immediate and sustained relief from osteoarthritis pain. This innovative approach offers a promising solution for those seeking an alternative to traditional treatments.
In this article, we will delve into the specifics of Cingal, its application, benefits, and what patients can expect from this treatment.
Key Takeaways
- Cingal is a non-opioid option for managing chronic knee pain due to OA, making it an essential choice for individuals looking for alternatives to opioid-based medications.
- Cingal injections combine corticosteroids and hyaluronic acid to relieve pain quickly and provide long-lasting knee joint lubrication for osteoarthritis patients.
- Clinical studies back the effectiveness of Cingal, showing that it can relieve knee pain, reduce stiffness, and improve joint function for up to 26 weeks after just one injection.
- The treatment is safe and has few side effects, like swelling or discomfort at the injection site. However, people who are allergic to its ingredients or have certain health conditions should not consume it.
- Patients report significant improvements in mobility and quality of life shortly after receiving the injection, allowing them to engage more in daily activities without severe pain.
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Introduction to Cingal Injections
Cingal injections serve as a single-treatment solution for osteoarthritis (OA), targeting chronic knee pain. This innovative therapy combines a corticosteroid’s immediate pain relief properties with the long-lasting lubrication benefits of hyaluronic acid viscosupplement, offering patients a dual-action approach to managing OA symptoms effectively.
By integrating these two components, Cingal provides fast-acting and enduring relief from pain, stiffness, and functional limitations associated with knee osteoarthritis. Hyaluronic acid, a viscosupplement, offers long-lasting joint lubrication, mimicking the natural synovial fluid in knees to improve mobility and reduce friction.
Mechanism of Action

Patients experience immediate relief from osteoarthritis (OA) symptoms following a Cingal injection, which combines the anti-inflammatory properties of a corticosteroid with the joint lubrication benefits of hyaluronic acid.
This dual-action treatment provides quick pain reduction and long-term joint support, making it an effective non-opioid option for managing OA. Cingal’s fast-acting relief from inflammation and pain highlights its potential to fulfill a critical need in OA symptom management.
Treatments like Cingal and Monovisc injections offer immediate pain relief and sustained joint lubrication, effectively addressing chronic knee pain associated with OA.
Cingal’s Efficacy and Safety

Clinical studies and patient reviews confirm that Cingal, a single-injection OA treatment, delivers fast-acting, long-lasting knee pain relief. The dual-action formulation combines a corticosteroid for immediate pain reduction with hyaluronic acid for prolonged joint lubrication.
Researchers have found Cingal to be a safe and effective non-opioid treatment option for chronic knee pain associated with osteoarthritis. Patients report significant improvements in pain, stiffness, and overall joint function, underscoring Cingal’s role as a next-generation therapy in OA management.
- Studies have shown that the effects of Cingal last up to 26 weeks, with patients reporting ongoing improvements in knee function and reduced inflammation during this period.
- Individuals who had struggled with chronic knee pain associated with OA noted a marked reduction in pain intensity, which allowed them to decrease their reliance on oral pain medications.
- Some testimonials highlight Cingal’s role in enhancing mobility, where patients could engage in physical activities that were previously too painful or difficult to perform.
- Patient satisfaction scores reflect high approval rates for Cingal, underscoring its effectiveness in managing OA symptoms when other non-opioid treatments have fallen short.
- The combination therapy aspect of Cingal—merging hyaluronic acid with a corticosteroid—receives particular praise for addressing both the symptoms and the underlying causes of discomfort.
- Feedback from older adults illustrates significant lifestyle improvements post-Cingal injection, including increased participation in social activities and exercises like walking or cycling without the hindrance of knee pain.
- Medical professionals also report patient outcomes indicating reduced knee stiffness, making morning routines more accessible and less painful for OA patients.
Cingal’s Injection Protocol

Cingal is administered as a single intra-articular injection to provide fast-acting and long-lasting relief from osteoarthritis knee pain. Combining hyaluronic acid with corticosteroid, this unique formulation allows significant pain relief lasting up to 26 weeks.
Medical professionals administer Cingal as a single intra-articular injection. This direct approach allows combining hyaluronic acid and corticosteroid to target the affected joint, providing rapid pain relief for patients suffering from osteoarthritis (OA). Proper administration is crucial to achieving optimal outcomes with Cingal injections.
Potential Side Effects and Contraindications
Patients receiving Cingal injections may experience common side effects similar to those associated with corticosteroid and hyaluronic acid treatments, including pain at the injection site, swelling, bruising, stiffness, or warmth in the knee.
These side effects are generally mild and resolve within a few days. A small number of patients report mild headaches or nausea. Healthcare providers should inform patients of these potential reactions and reassure them of the treatment’s long-term benefits.
Cingal is contraindicated for patients with allergies to its components, infections at the injection site, or bleeding disorders. Pregnant or lactating women should consult their healthcare provider before using Cingal due to insufficient safety data.
Conclusion
Cingal offers a groundbreaking approach to OA treatment. It blends the quick relief from corticosteroids with the durable benefits of viscosupplements. It is a versatile and effective solution for managing chronic knee pain linked to osteoarthritis.
With its single-injection protocol, Cingal paves the way for both immediate and lasting relief, making it an appealing option for patients seeking non-opioid treatments. This innovative therapy marks significant progress in addressing knee pain and enhancing the quality of life for OA patients.
FAQs
1. What is a Cingal injection used for?
A Cingal injection treats pain in osteoarthritis (OA) joints.
2. How does the Cingal injection work?
The Cingal injection combines a steroid with hyaluronic acid to reduce pain and improve joint movement.
3. Is getting a Cingal injection painful?
You might feel some discomfort, but it’s generally quick and manageable.
4. How long does it take for the Cingal injection to start working?
Some people may notice improvement within a few days, but manifesting the full effects can take up to two weeks.
5. How often do I need to get a Cingal injection?
The frequency of injections depends on your condition, but typically, one injection provides relief for several months.
References
Pereira, T. V., Jüni, P., Saadat, P., Xing, D., Yao, L., Bobos, P., … & da Costa, B. R. (2022). Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. bmj, 378.
Hangody, L., Szody, R., Lukasik, P., Zgadzaj, W., Lénárt, E., Dokoupilova, E., Bichovsk, D., Berta, A., Vasarhelyi, G., Ficzere, A., Hangody, G., Stevens, G., & Szendroi, M. (2018). Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial. Cartilage, 9(3), 276–283. https://doi.org/10.1177/1947603517703732
Anika Therapeutics, Inc. (n.d.). Overview. Cingal. Retrieved from https://www.cingal.com/the-patient-experience/overview/
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