Juvederm Volite Side Effects


Skin care


Juvederm Volite is a revolutionary product from one of the world’s leading cosmetic injectable brands.

Doctor Medica team

Juvederm Volite is a revolutionary product from one of the world’s leading cosmetic injectable brands. Not a traditional dermal filler, it is designed to intensely hydrate the skin, improving skin quality for up to 9 months. A conditioning gel made of hyaluronic acid (HA), it is injected into the middle layers of the dermis. The following are common side effects and precautions to keep in mind when treating patients with Juvederm Volite: 

Common Side Effects

  1. Inflammatory reactions, such as redness, edema, and erythema, possibly with itching, pain, pressure, or paresthesia (tingling). These may occur after injection and last for up to a week.
  2. Hematomas (bruising).
  3. Induration (hardening) or nodules (lumps) at the injection site.
  4. Staining or discoloring at injection site, especially with too superficial an injection, called the Tyndall effect.
  5. Poor or weak filling effect.
  6. Rare but serious side effects after intravascular injection and tissue compression. These may include temporary or permanent vision impairment, blindness, cerebral ischemia (insufficient blood flow to the brain) or cerebral hemorrhage leading to stroke, skin necrosis (death), and damage to underlying structures. Stop injection immediately if a patient has symptoms including vision changes, signs of stroke, skin blanching, or unusual pain during or soon after the injection. Ensure the patient receives prompt medical attention and possibly sees a specialist if there is an intravascular injection.
  7. Rarely, abscesses, granuloma, and immediate or delayed hypersenstivity. 
  1. Intended for injection by qualified medical practitioners with appropriate training and experience in injection techniques and anatomy knowledge.
  2. Only for intradermal injection.
  3. Not for use in breast augmentation or reconstruction.
  4. Injector must take into account the presence of lidocaine in this product. 
  5. Do not inject into the eyelids.
  6. Not for intravascular injection (into blood vessels) because this could cause embolization (blocked blood vessels), vessel occlusion (blockage), ischemia (inadequate blood supply), or infarction (obstruction of blood supply causing local tissue death).
  7. Not for use in patients who have untreated epilepsy; patients who tend to develop hypertrophic scarring; patients with a known hyaluronic acid sensitivity or gram-positive bacterial protein sensitivity, due to the fact that this hyaluronic acid is produced using Streptococcus-type bacteria; patients with a known lidocaine sensitivity or amide-type local anesthetic sensitivity; or patients with porphyria.
  8. Not for use in pregnant patients.
  9. Not for use in breastfeeding patients.
  10. Not for use in children.
  11. Not for use in areas with skin inflammation or infection, such as acne and herpes.
  12. Not for simultaneous use with laser treatment, deep chemical peels, or dermabrasion. Do not inject this product if there is a significant inflammatory reaction from surface peels.
  13. There is no clinical data about injecting into an area already treated with a filler or product from another brand.
  14. Not for injection into a site with a permanent implant.
  15. Injection carries an infection risk. Use standard precautions relating to injectable materials.
  16. There is no data regarding efficiency and tolerance of this product in patients who currently have, or have a history of, autoimmune deficiency or who are undergoing immunosuppressive therapy. Decide case-by-case whether to inject, depending on the nature of disease and its treatment. Monitor these patients and perform a preliminary skin test for hypersensitivity before treatment, avoiding injection if the disease is active.
  17. There is no data regarding tolerance in patients with a history of severe or multiple allergies. Decide case-by-case whether to inject, depending on the nature of the allergy. Specially monitor these patients. Propose a skin test for hypersensitivity or administer a suitable preventative treatment before injection. The manufacturer does not recommend injecting if there is a history of anaphylactic shock.
  18. Perform a skin test for hypersensitivity before injecting patients who have a history of streptococcal disease, including recurrent sore throats or acute rheumatic fever. The manufacturer does not recommend injecting if there is acute rheumatic fever with heart complications.
  19. Warn patients of potential increased risk of bleeding and hematomas (bruising) during injection if they are taking anti-coagulation drugs; using substances that can prolong bleeding, such as warfarin, acetylsalicylic acid, and nonsteroidal anti-inflammatory drugs; or using substances that increase coagulation time, such as herbal supplements containing garlic or ginkgo biloba.
  20. Since there is lidocaine in this product, the manufacturer does not recommend combining it with certain drugs that reduce or inhibit hepatic metabolism, such as cimetidine and beta-blockers.
  21. Since there is lidocaine in this product, use caution in patients with symptoms of cardiac conduction disorders.
  22. Inform the patient that they should not use makeup for at least twelve hours following injection.
  23. Inform the patient that they should avoid extended exposure to sun, UV, and temperatures below freezing, and sauna or hammam sessions, for at least two weeks following treatment.
  24. This product is compatible with magnetic resonance imaging (MRI) fields.
  25. The hyaluronic acid in this product is incompatible with benzalkonium chloride and other quaternary ammonium salts. Do not allow it to come into contact with these substances or with medical/surgical instruments treated with these substances.
  26. There is no known interaction with other local anesthetics.
  27. Do not modify this product or it could affect sterility, homogeneity, and product performance.
  28. Check expiry date on product label before use.
  29. If syringe contents are cloudy or show signs of separation, do not use.
  30. Do not re-use. Sterility cannot be guaranteed.
  31. Do not re-sterilize.
  32. Do not try to straighten a bent needle. Instead, replace it. 

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