Synvisc vs Durolane – Which is the Better Viscosupplement

Viscosupplementation is a widely used treatment for osteoarthritis, involving hyaluronic acid (HA) injections to enhance joint lubrication and reduce pain. Research suggests that this therapy can effectively delay the need for more invasive procedures, such as knee replacement, and is particularly beneficial for managing pain in early to moderate cases of osteoarthritis.

Two leading HA-based viscosupplements are Synvisc and Durolane. Synvisc uses a cross-linked formula designed for longer-lasting results, while Durolane offers a single-injection solution with a high concentration of HA. Both treatments aim to improve joint function but differ in administration and formulation.

In this article, we will compare Synvisc vs Durolane, exploring their effectiveness, potential side effects, and benefits to help you choose the best option for your needs.

Key Takeaways

•  Synvisc and Durolane are treatments for knee pain caused by osteoarthritis. Synvisc, made from rooster combs, requires three shots, while Durolane, made from non-animal hyaluronic acid, requires only one shot.
• Durolane might work longer because of its NASHA technology, but studies show that three shots of Synvisc can provide better relief than one of Durolane.
• Both have side effects like pain at the injection site or swelling. Yet, they help many with joint pain and movement.
• Patients like Durolane for its one-shot ease and lasting results. Synvisc is also helpful, but it might require more doctor visits.
• Choosing between them depends on personal needs, like how often you want to visit the doctor or if you prefer animal-based products.

About: Doctor Medica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices in the market. If you’re looking to order Synvisc online for your practice, contact the Doctor Medica today.

Introduction to Viscosupplements

Viscosupplements are a therapeutic option for treating knee osteoarthritis by injecting hyaluronic acid (HA) directly into the joint. In osteoarthritis, the protective synovial fluid that cushions joints becomes thinner and less effective, leading to pain, stiffness, and reduced mobility.

Viscosupplements containing hyaluronic acid (HA) mimic this natural fluid, enhancing joint lubrication and acting as a shock absorber. This helps to reduce pain, improve joint movement, and can delay the need for more invasive treatments, such as knee replacement surgery.

Composition and Mechanism of Action

• Synvisc: Synvisc is derived from rooster combs and contains hyaluronic acid. Its primary function is to act as a lubricant and shock absorber within the knee joint, helping reduce friction and cushion the knee during movement. By mimicking the body’s natural joint fluid, Synvisc helps alleviate pain and improve joint function for those with osteoarthritis.
• Durolane: Durolane, a single-injection hyaluronic acid treatment, uses non-animal-based hyaluronic acid produced through NASHA technology. This advanced technology enhances the product’s viscosity and longevity, providing prolonged pain relief and improved joint function. The single-injection format also offers convenience, making it a popular choice for osteoarthritis patients seeking effective and lasting treatment.

Effectiveness in Osteoarthritis Management

Synvisc

Clinical studies show Synvisc helps with knee osteoarthritis. One study found that three shots of Synvisc gave better relief than one shot of another medicine, Durolane. This means Synvisc can make a big difference for people with this joint problem.

Doctors see that patients who get Synvisc feel better. They have less pain and move more efficiently. This is because Synvisc works well as a shock absorber and lubricant in the knee. A study demonstrates the interest in high molecular viscosupplementation with Synvisc in managing severe knee OA patients. 82% of candidates for total knee replacement at baseline were able to delay this surgical treatment.

Durolane

Durolane has also been extensively studied for its effectiveness in treating osteoarthritis of the knee. Clinical trials have demonstrated that Durolane provides significant pain relief and improved joint function in patients who have not responded adequately to conservative treatments such as physical therapy and analgesics.

A systematic review of clinical evidence highlighted that Durolane injections significantly reduced pain and enhanced mobility for patients with knee osteoarthritis. The review included multiple randomized controlled trials and observational studies, reinforcing the consistent positive outcomes associated with Durolane treatmen

Safety Profiles and Side Effects

Both Synvisc and Durolane can lead to several common side effects following the injection. These include:

• Pain at the Injection Site: Mild pain or discomfort is common shortly after receiving the shot.
• Swelling in the Knee: Fluid buildup may cause temporary swelling around the joint.
• Stiffness: The knee may feel tighter, making movement more difficult for a short period.
• Heat in the Knee: Patients often report a warm sensation near the injection area.
• Rash or Itching: Skin irritation may occur around the knee, such as redness or itching.
• Trouble Walking: Pain or swelling could temporarily hinder mobility.
• Bruising: Minor bruising may appear at the injection site.

Rare but Serious Side Effects

While uncommon, both Synvisc and Durolane can cause more severe side effects, including:

• Severe Allergic Reactions: Synvisc, derived from rooster combs, may pose a higher risk for individuals allergic to bird proteins, feathers, or egg products. Symptoms include swelling of the face, difficulty breathing, or severe itching.
• Infection or Inflammation: In rare cases, the injection site can become infected, leading to more serious complications.
• Excessive Swelling or Pain: If swelling or pain worsens after a few days, it could indicate a more serious issue requiring medical attention.

Patient Satisfaction and Long-Term Outcomes

Many people with knee osteoarthritis have tried Synvisc to see if it could help their knees feel better. Some found that after getting three shots of Synvisc, their knees did indeed feel less painful. To achieve these results, it is optimal that people follow Synvisc dosage. But not everyone had the same experience. 

Based on a large, observational study to assess its tolerability and short-term effectiveness, Synvisc has a demonstrated safety profile, and over 80% of patients were satisfied, rating it as a “good” or “very good” therapy at 3 weeks after the first injection.

Meanwhile, Durolane patients often see longer-lasting relief from knee osteoarthritis. Durolane uses NASHA technology, which helps hyaluronic acid stay in the joint longer than Synvisc. People only need one shot of Durolane for good results, which makes it easier than getting three shots of Synvisc.

Durolane’s single injection has high levels of hyaluronic acid, which means it also works well for a long time.

Conclusion

When choosing between Synvisc vs Durolane, it’s essential to consider your specific needs and preferences. Durolane offers the convenience of a single injection and provides longer-lasting relief, while Synvisc, with multiple injections, can still be highly effective in managing knee pain caused by osteoarthritis.

Both treatments have potential side effects, so consulting with your doctor will help determine which option best suits your condition and lifestyle. By discussing your symptoms and goals, you can make an informed decision for lasting joint relief.

FAQs

1. What are Synvisc and Durolane?

Synvisc and Durolane are types of viscosupplements used to treat symptoms of knee arthritis by improving joint fluid.

2. How do Synvisc and Durolane work?

Synvisc and Durolane work as lubricants or shock absorbers, replacing or supplementing the natural synovial fluid in your knee joints.

3. Which is a better viscosupplement: Synvisc or Durolane?

The effectiveness of these treatments can vary from person to person. Consult with your doctor about which option might be better for you based on your health condition.

4. Are there any side effects associated with using Synvisc or Durolane?

Yes, both treatments may cause pain at the injection site, swelling, heat sensation, rash, or itching. If these persist or worsen over time, it’s recommended that you seek medical attention immediately.

References

Peck, J., Slovek, A., Miro, P., Vij, N., Traube, B., Lee, C., Berger, A. A., Kassem, H., Kaye, A. D., Sherman, W. F., & Abd-Elsayed, A. (2021). A comprehensive review of viscosupplementation in osteoarthritis of the knee. Journal of Clinical Medicine, 10(25549). https://doi.org/10.52965/001c.25549

Viscosupplementation treatment for arthritis. Johns Hopkins Medicine. Published December 15, 2021. https://www.hopkinsmedicine.org/health/conditions-and-diseases/arthritis/viscosupplementation-treatment-for-arthritis

RxList. (n.d.). Synvisc (Hylan G-F 20) drug information. Retrieved September 18, 2024, from https://www.rxlist.com/synvisc-drug.htm