Restylane vs. Botox: Which One is Better?

Dermal Fillers


Last Updated On: 2024-01-12

While both Restylane and Botox are effective treatments for facial rejuvenation, they have different applications and target areas.

Doctor Medica team

Facial rejuvenation has become increasingly popular as patients seek non-surgical options to enhance their appearance. Among the many available treatments, Restylane and Botox have emerged as leading options among aesthetic treatments.

Both Restylane and Botox are highly effective in addressing common aesthetic concerns, like fighting wrinkles and plumping up the skin, but they differ in their composition, mechanism of action, and target areas. So let’s dive deeper to understand the similarities and differences between these two products’ features and possibilities to decide which is better – Restylane or Botox.

What Is Restylane?

Restylane is a well-known dermal filler widely used in aesthetic medicine. It is composed of hyaluronic acid (HA), which provides hydration and volume to the skin.

Restylane works by replenishing lost volume, filling in wrinkles, and enhancing facial contours. When injected into the skin, it attracts and binds with water molecules, improving skin texture and smoothness.

Restylane is commonly used for various facial areas, including the nasolabial folds, marionette lines, and lips. It effectively reduces the appearance of wrinkles and adds volume to specific areas, resulting in a more youthful and rejuvenated appearance.

There are several types of Restylane. Depending on the density and composition, you can choose a suitable option for a specific purpose. For example, Lip Volume is used to increase the volume of lips, and Skinboosters are used for biorevitalization. 

The benefits of Restylane include its long-lasting results, natural-looking outcomes, and the ability to customize treatments based on individual patient needs. In addition, hyaluronic acid, included in the composition, is not of animal origin, so the risk of side effects is minimal.

What Is Botox?

Botox, a purified form of Botulinum Toxin, is a popular injectable treatment used to address dynamic wrinkles formed by repeated muscle contractions. 

The neurotoxin, injected under the skin, blocks the nerve impulses transmission to the muscle and relaxes it. The effect is local: only in those muscles where the injections were made. Relaxed muscles cause wrinkles and dermal folds to smooth out naturally.

Botox injections are used in solving many cosmetic problems:

  • Horizontal wrinkles of the forehead, lower eyelid, and décolletage;
  • Deep interbrow wrinkles;
  • Vertical wrinkles on the face and neck;
  • “Crow’s feet” in the eye area;
  • Wrinkles in the lip area.

Botox reduces their appearance by temporarily relaxing the underlying muscles responsible for these wrinkles and preventing further wrinkle deepening. 

Botox begins to work within a week after the procedure, the maximum result is fixed after two weeks, and the effect lasts from 4 to 6 months. It is not a one-time procedure that will help solve antiaging problems forever. Botox treatments must be repeated, after a certain period, depending on the longevity of the effect for the patient.

In addition, Botox injections can solve some medical problems:

  • Reduce the volume of masticatory muscles;
  • Get rid of migraines;
  • Tighten the face oval;
  • Raise the corners of the eyes and lips;
  • Get rid of twitching of the muscles around the eyes;
  • To block neural signals that lead to the active work of sweat glands (hyperhidrosis).

Botox offers distinct advantages, including its ability to provide a more youthful and refreshed look with minimal downtime and without surgery.

Differences Between Botox and Restylane

The main difference between these two treatments is the purpose of the injections because Botox is used to combat active facial expressions and works with muscles, while Restylane is used to fill the lack of volume.

While both Restylane and Botox are effective treatments for facial rejuvenation, they have different applications and target areas. Restylane primarily focuses on replenishing lost volume and smoothing out wrinkles, making it suitable for the areas like nasolabial folds and lips. Botox, on the other hand, is specifically designed to address dynamic wrinkles caused by muscle contractions, making it ideal for crow’s feet, forehead lines, and frown lines.

The other big difference between Botox and Restylane is that the effect of botulinum toxin treatment is noticeable immediately, and after filler injection, the result increases over time.

Botox requires three to five injections per visit. The procedure takes about 10 minutes. Results are often noticeable after one or two days.

Restylane treatment may take up to an hour, and recovery takes less than a day. Even though the first effect is noticeable immediately, the final result will be visible after one or two weeks.

The duration of results varies between Botox vs. Restylane. Restylane typically lasts around 6 to 12 months, depending on the treatment area, individual metabolism, and lifestyle habits. 

Botox results usually last for approximately 3 to 4 months, after which the treatment can be repeated to maintain the desired outcome. But individual responses may vary, and patient factors should be considered when determining the optimal treatment frequency.

Advantages and Side Effects

Both Restylane and Botox are FDA-approved and have a well-established safety profile when administered by trained medical professionals. Restylane is formulated with biocompatible and biodegradable hyaluronic acid, minimizing the risk of adverse reactions. Botox has been successfully used in the medical field long before cosmetology and was extensively studied and approved by regulatory authorities for its cosmetic applications.

Restylane is highly effective in restoring lost volume, providing plumpness to the lips, and smoothing out wrinkles. It offers immediate results, allowing patients to enjoy a more youthful appearance soon after the treatment. Restylane’s versatility and ability to target specific areas make it a popular choice for patients seeking facial rejuvenation.

Botox, on the other hand, excels in reducing the appearance of dynamic wrinkles developed due to muscle movement. It is particularly beneficial for patients who wish to soften lines around the eyes, forehead, and between the eyebrows. In addition, botox treatments are quick, convenient, and require minimal downtime, making them suitable for patients with busy lifestyles.

Common side effects associated with Restylane and Botox treatments are similar and typically mild and temporary. These may include redness, swelling, bruising, and tenderness at the injection site. These side effects usually resolve within a few days.

Serious complications after those treatments are rare but can include infection, allergic reactions, or asymmetry if not administered correctly. Therefore, doctors must comprehensively understand facial anatomy and injection techniques to minimize any potential risks.

Combination Approaches

In many cases, doctors may recommend a combination approach using both Restylane and Botox to achieve comprehensive facial rejuvenation.

By addressing volume loss with Restylane and targeting dynamic wrinkles with Botox, doctors can create natural-looking results that harmoniously enhance the patient’s facial features. 

If deep static skin creases remain after Botox therapy, then cosmetologists use medium-density Restylane fillers.

This integrated approach allows creating a more comprehensive and tailored treatment plan, delivering optimal patient outcomes.


Restylane and Botox are two prominent treatments in facial rejuvenation, offering effective solutions for different aesthetic concerns. Restylane excels in replenishing lost volume and smoothing out wrinkles, while Botox specifically targets dynamic wrinkles caused by muscle contractions. 

The choice between Restylane and Botox depends on the patient’s unique needs and desired outcomes. By understanding the unique properties of each treatment, doctors can provide tailored solutions that meet their patient’s best interests.


Does Botox last longer than Restylane?

Yes, Botox typically lasts longer than Restylane. Botox injections usually provide results that last for around 3 to 4 months, while Restylane injections generally last for about 6 to 12 months. 

However, the duration of the effects can vary depending on individual factors such as metabolism, lifestyle, and the area being treated.

How is Restylane different from Botox?

Restylane and Botox are effective treatments for rejuvenating the face, but they have different mechanisms of action. Restylane adds volume and fills in wrinkles, while Botox relaxes muscles to reduce the appearance of wrinkles caused by muscle movements. 

The choice between Botox or Restylane depends on the individual’s specific concerns and goals, and a qualified aesthetic doctor can help determine the most suitable treatment option.


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