The Complete Guide To Mesotherapy Skin Rejuvenation Treatment

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Last Updated On: 2024-01-26

Mesotherapy refers to a non-surgical skin rejuvenation therapy. Mesotherapy helps to to treat Cellulite, fat removal and other medical conditions

Doctor Medica team

Mesotherapy refers to a non-surgical skin rejuvenation therapy that was first developed in France by Michel Pistor. Traditionally, mesotherapy was used to treat medical conditions, including rheumatologic and traumatic disorders. However, since its recognition by the French Academy of Medicine in 1987, it became a popular treatment method for cellulite reduction, alopecia, acne scarring, and facial rejuvenation.
It involves a diverse array of cutaneous injection techniques, using suitable products and compounds to provide the following benefits:

  1. Increases the biosynthetic capacity of fibroblasts;
  2. Produces new collagen, elastin, and hyaluronic acid;
  3. And enhances cellular activity.

How will mesotherapy help me?

Mesotherapy injections contain biocompatible and completely biodegradable materials, which are injected intradermally to rejuvenate the face, reduce cellulite, tighten loose skin, re-contour the face and body, and treat hyperpigmentation. Due to differences in pharmacological availability and laws regulating medical practices between the United States and European countries, the practice of mesotherapy, as well as the composition of each formula, may differ from country to country. There is no standardized formulation in mesotherapy; physicians may use different solutions, including enzymes, vitamins and minerals, hormones, and other prescription medications during these treatments.


The most common application of mesotherapy in the United States is cosmetic, specifically for facial rejuvenation, cellulite, alopecia, and localized fat deposits.

Facial Rejuvenation

The skin becomes relatively atrophic, lax, and wrinkled with age. UV light exposure, smoking, and environmental pollutants cumulatively accelerate skin aging. Luckily, mesotherapy can help reduce the mild signs of aging, providing hydration and nutrients to the skin.
Mesotherapy for skin rejuvenation does not require a skin test prior to injection. As such, it’s easy to use and is good for mild to moderate aging. There is no downtime or recovery time involved with this treatment, and it can be performed on almost all skin type, just like Belotero and similar products.

Fat Reduction (weight loss)

Doctors often recommend sessions of mesotherapy for fat reduction, with 2 to 4 weeks intervals.

Cellulite Treatment

Phosphatidylcholine and deoxycholic acid are the major components of mesotherapy treatments for cellulite. The mode of action of this combination treatment is poorly understood. Common protocol used by a number of physicians includes injection lipolysis, followed by mesotherapy and lymphatic massage.

Lower Eyelid Fat (Blepharoplasty)

Lower eyelid fat is often treated with surgical blepharoplasty. At least 1-2 mesotherapy sessions are recommended to treat fat pads in the lower eyelids. Swelling is a common side effect, and the patient may need to take cortisone prior to injection to fight off inflammation.


During this process, the skin is infused with potent vitamins and minerals, antioxidants, vasodilators, and other substances, depending on the condition and area being treated. Mesotherapy formulations may contain the following ingredients:

  Active Ingredients  Hyaluronic acid and/or sodium hyaluronate
  Vitamins  Vitamin A, vitamin B complex (thiamine, riboflavin, niacin, pantothenate, pyridoxine, folic acid, and cyanocobalamin), vitamin C, vitamin E, vitamin K, vitamin D, biotin, and inositol
  Minerals  Sodium, potassium, calcium and magnesium
  Amino Acids  Alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, and valine
  Coenzymes  Carboxylase, coenzyme A, Flavin adenine dinucleotide, nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and uridine triphosphate
  Nucleic acids  Deoxyadenosine, Deoxycytidine, Deoxyguanosine, Deoxythymidine, and Methylcytosine
  Reducing agents  Ascorbic acid and Glutathione


Injection Techniques

Physicians must be aware of the multiple injection techniques relevant to aesthetic mesotherapy and must be skilled at determining proper injection depth. Different depths of injection vary depending on the thickness of the skin at the injection site.

Serial Puncture (Papule)DermisFacial rejuvenation
NappageEpidermis/DermisFacial rejuvenation
Point-by-pointDeep DermisCellulite, rheumatology, sports medicine
  1. Prepare the cutaneous surface following proper aseptic technique.
  2. Injection must be performed with the patient lying down.
  3. For each session, map the area to be treated.
  4. The injection can be performed manually, or through a mesotherapy gun, using papule, nappage, or point-by-point techniques.
  5. The needle must be perpendicular to the skin.
  6. Introduce the needle to the skin from a depth of 2 to 6mm.
  7. Inject 0.1–0.8ml solution with a distance of 0.50–5cm.

Side Effects

Potential adverse effects vary based on the type of medication to be injected, the manner of administration, medications taken prior to injection, and the expertise of the administrator. Patients may experience mild and transient side effects, lasting from days to a week. Serious complications may also occur.
Adverse effects:

  1. Bruising
  2. Swelling
  3. Redness
  4. Burning sensation
  5. Itching
  6. Pain or tenderness
  7. Allergic reactions
  8. Dizziness
  9. Hyperpigmentation
  10. Necrosis
  11. Abscess formation
  12. Infection


The overall cost of the procedure depends on the amount of medication required to treat the patient’s condition, or to achieve the desired outcome. The average cost for a single session ranges from $250–$600 in the United States.
The procedure for facial rejuvenation is well-tolerated by most patients. The punctured areas may appear reddened after injection. Several sessions are often needed to achieve the desired outcome. Talk to your doctor about the various types of mesotherapy treatments, and whether they might be right for you.

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