Juvederm vs. Botox: What’s The Difference?

Dermal Fillers


Last Updated On: 2024-01-08

Juvederm and Botox’s main differences are their composition, mode of action, target areas, and duration of effect.

Doctor Medica team

Despite the vast range of cosmetic procedures on the market, botulinum toxin, commonly known as Botox, and dermal fillers, such as Juvederm, have been among the most popular reasons to visit a cosmetic surgeon for years. 

These rejuvenation methods differ in the injection technique, the active ingredients in the composition, and the principle of action. This article will explain how Botox and Juvederm dermal filler treatments work, their benefits, and the nuances of patient choice for Botox vs. Juvederm.

What Is Juvederm?

Under the brand name Juvederm, there are several types of dermal fillers designed to achieve specific cosmetic effects. Conditionally, we can divide them into two major groups, described below.

Ultra Series

This product line corrects specific facial areas and includes hyaluronic acid of different densities. The gel also contains a special component to prevent the substance from spreading under the skin after application.

The product line comprises:

  1. Ultra 2 – Corrects fine wrinkles, adds skin elasticity, and contours the face. Used for lip augmentation. Lasts up to 10 months.
  2. Ultra 3 – Dense gel for significant corrections on the forehead, nose, lips, and cheeks. Compensates for lack of soft tissues in the chin area. Lasts up to a year.
  3. Ultra 4 – The densest gel for shaping the facial oval and contours. Allows lip and cheek augmentation. Deep injection with effects lasting up to a year.
  4. Ultra Smile – Special product for increased lip volume and shape correction. Effects last 10-12 months.

VyCross Series

This line provides longer-lasting correction effects.

The product line includes:

  1. Voluma – Adds volume to areas with insufficient soft tissues. Lasts up to 1.5 years.
  2. Volift – Shapes and contours the middle and lower face, eliminates skin defects, corrects lips, and removes nasolabial folds. Lasts 15 months.
  3. Volift Retouch – Hyaluronic filler for the additional correction of the facial oval, lips, wrinkles, furrows, and nasolabial folds. Effects last up to 15 months.
  4. Volbella – Specialized gel for fine wrinkle elimination on the delicate, thin skin of the upper face. Addresses eye-area skin defects and shapes the lips. Effects last for a year.
  5. Volite – High-plasticity injection combining filler and revitalizing effects. Replenishes skin cell fluid, provides a lifting effect, and reinforces the face. Rapidly manifests after injection, lasting up to 9 months.

What Is Botox?

Botox is a botulinum toxin-based drug actively used in cosmetology. It is used to block neuromuscular transmission, thus eliminating expression lines, migraine attacks, and hyperhidrosis.

The product belongs to the muscle relaxants category. It provides potent muscle blockade while having limited impact. The effect of its application is localized only to the injection sites.

Botulinum toxin does not migrate to neighboring tissues, affect internal organ functions, trigger allergic reactions, or negatively impact overall well-being. 

The medication is intended for intramuscular injection using a fine needle. Only minor traces and bruises remain at the injection sites, which fade within a few days.

After the administration of Botulinum toxin, muscle fibers are inhibited at the neuromuscular junction and reduced in the activity of muscle stretch receptors.

Advantages of Juvederm

The basis of the preparations is hyaluronate (hyaluronic acid) – a substance biologically compatible with human tissues and body fluids. Decreased hyaluronate content with age results in cosmetic defects, such as dryness, dehydration, sagging, etc. Hyaluronic acid promotes long-term fluid retention in the skin, renews its structure, and slows down aging.

The hyaluronic acid in the products is of inorganic origin, which completely excludes allergic reactions and rejection by the body.

Juvederm products contain lidocaine – a component that eliminates pain during the procedure.

Let’s summarize the advantages:

  • Hypoallergenic;
  • Painless injection;
  • Effect lasting 10 months to 1.5 years;
  • Minimal side effects;
  • Evenly distributed under the skin.

Side Effects of Juvederm

Juvederm products are based on hyaluronic acid and are safe for the human body. Contraindications to cosmetic procedures with their use are only general cases:

  • Acute diseases or exacerbation of chronic pathology;
  • Inflammatory processes in the injection area;
  • Conditions that interfere with blood clotting;
  • Pregnancy and lactation.

Advantages of Botox

Among the advantages of botulinum therapy, we can confidently refer to the following:

  • Affordability: Botulinum therapy is reasonably priced, especially considering the procedure’s effects and longevity. This is an obvious advantage in the Juvederm versus Botox comparison.
  • Wide selection of products: Despite being a unique procedure, various brands are available for botulinum therapy, such as Botox, Dysport, Xeomin, Relatox, Botulax, and more.
  • Rapid results: Within 3-5 days, depending on the product, the initial effects of botulinum toxin injections can be observed, with maximum results achieved by the second week.
  • Safety: Contrary to common belief, botulinum therapy is safe as it uses minimal doses of botulinum toxin type A. Additionally, the toxin is completely eliminated from the body without negatively affecting the liver.
  • No tissue sagging after the effects wear off: Dispelling another common myth, botulinum toxin does not cause dependence, and once it is eliminated from the body, the tissues return to their natural position.
  • Natural facial expressions: When performed skillfully, botulinum therapy does not make your facial expressions disappear or give your face a masked appearance. The key is to choose a skilled practitioner.
  • Quick procedure: Botulinum therapy typically takes 20-30 minutes to complete.

Side Effects of Botox

  • Involuntary muscle spasm (seen usually after injections in the eye area);
  • Paralysis of facial muscles;
  • Lowering of the eyebrows;
  • Severe swelling;
  • Severe subcutaneous hemorrhage (bruising);
  • Disruption of upper lip mobility;
  • Severe headaches.

Patient Selection

When selecting patients for Juvederm or Botox procedures, several factors are considered to ensure safe and effective outcomes:

  • Age: Botox and Juvederm are typically used in adults aged 18 and above, although age restrictions may vary based on regulations.
  • Cosmetic Concerns: Patients should have specific cosmetic concerns that can be addressed by Botox (dynamic wrinkles) or Juvederm (volume loss).
  • Medical History: A thorough medical history evaluation is crucial to identify contraindications or potential risks. Allergies, previous treatments, medications, and medical conditions that may impact eligibility are assessed.
  • Expectations: Clear communication about desired outcomes is vital to establish realistic goals, managing expectations for the procedures, and choosing a suitable cosmetic product.
  • Physical Examination: A comprehensive physical examination helps assess facial anatomy, skin condition, and target areas for treatment. This evaluation is vital for the final treatment choice and guides the selection of injection sites and treatment plans.
  • Overall Health: Patients should be healthy, without active infections or skin conditions in the treatment area. Reviewing the patient’s medical history to choose between Botox and Juvederm is essential.


In conclusion, Botox and Juvederm are popular cosmetic procedures offering different rejuvenation approaches. Juvederm dermal fillers, consisting of hyaluronic acid, are mainly used for adding volume. They provide long-lasting effects, improve skin structure, are hypoallergenic, and offer minimal side effects. 

On the other hand, Botox, based on botulinum toxin, offers affordability, a wide selection of products, and rapid results. It is considered safe when administered in small doses and does not cause tissue sagging once the effects wear off. Skilled administration preserves natural facial expressions. However, there are potential side effects, such as muscle spasms, facial muscle paralysis, swelling, and headaches.

Overall, both Botox and Juvederm offer practical and effective solutions for cosmetic enhancement, and a personalized approach is key to achieving safe and desirable outcomes.


What are the main differences between Juvederm and Botox?

Juvederm and Botox’s main differences are their composition, mode of action, target areas, and duration. 

Is Juvederm better than Botox?

It is inaccurate to say which is better, Botox or Juvederm. These are different treatments that serve different purposes. Juvederm is a dermal filler primarily used to restore volume and treat wrinkles, while Botox is a muscle relaxant that targets dynamic wrinkles.

What lasts longer, Botox or Juvederm?

There is a difference between Botox and Juvederm in their effect duration. The effects of Juvederm can last from several months to more than a year, depending on the product used and other factors, while Botox results last for 3-4 months.

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