HYALURONIDASE 1500iu 5 vials

HYALURONIDASE 1500 IU is a lyophilized enzyme preparation used primarily for the rapid and targeted degradation of hyaluronic acid-based dermal fillers. It is highly effective in clinical aesthetic practice for managing overcorrection, granulomas, vascular compression, and Tyndall effect caused by inappropriate or excessive filler injection. The enzyme works by hydrolyzing the bonds between N-acetyl-D-glucosamine and D-glucuronic acid, the building blocks of hyaluronic acid polymers. This allows for rapid filler dissolution, restoring the area to its baseline appearance or preparing it for a revised injection. The product is generally diluted in saline and used immediately after reconstitution to preserve its activity. An allergy test is essential before administration due to the risk of hypersensitivity reactions, even on first use.

HYALURONIDASE is injected directly into the area of concern, targeting the filler excess or granuloma for localized correction. Proper dilution and pre-injection allergy testing are crucial.

• Presentation: Lyophilized powder (1500 IU)
  
• Dilution: Typically 1500 IU in 4 ml saline (can vary)
  
• Test dose: 0.1 ml subcutaneous intradermal allergy test (150 IU/ml)
  
• Injection method: Retrograde or bolus injection at or near the filler site
  
• Needle size: 32G recommended
  
• Timing: Immediate injection recommended in case of vascular compromise
  
• Onset of action: Visible within 1 hour; full result by day 3

HYALURONIDASE is indicated for aesthetic and medical purposes where reversal of hyaluronic acid fillers is necessary. It helps treat complications such as:

• Overcorrection from dermal fillers
  
• Tyndall effect (bluish skin discoloration from superficial filler placement)
  
• Granulomas (inflammatory nodules)
  
• Vascular occlusion/necrosis risk
  
• Fibrosis from cellulitis (historical use)
  

Contraindications:

• Known allergy to hyaluronidase
  
• Prior sensitization to the enzyme
  
• Use in non-hyaluronic acid filler complications (e.g., silicone, PLA)
  

Possible side effects:

• Immediate hypersensitivity (anaphylaxis, urticaria, angioedema)
  
• Intermediate reactions (macular rashes, itching after 24h)
  
• Localized bruising or swelling
  
• Delayed inflammation in rare cases

• Active ingredient: Hyaluronidase (1500 IU per vial)
  
• Form: Lyophilized powder for reconstitution
  
• Diluent: Sterile physiological saline (NaCl 0.9%)
  
• Source: Typically ovine-derived

• 5 vials of lyophilized hyaluronidase (each containing 1500 IU)
  
• No preservatives or stabilizers
  
• Requires dilution before use
  
• No prefilled syringes included

While generally well-tolerated, hyaluronidase may cause side effects, particularly in sensitized individuals.

• Common: Temporary swelling, erythema, bruising at injection site
  
• Less common: Itching, redness, discomfort
  
• Rare: Anaphylactic shock, systemic allergic reaction
  
• Delayed: Large, red itchy macules (resolving within days)
  

Always perform an intradermal allergy test before injection.

• Storage form: Lyophilized powder
  
• Storage temperature: Store at 2–8°C (refrigerated)
  
• Shelf life: As per manufacturer instructions
  
• After reconstitution:
  
  • Use immediately
    
  • Do not store reconstituted solution
    
• Protect from light and moisture