SESDERMA®

About Sesderma® — Professional Cosmeceutical Skincare from Spain

Sesderma® was founded in 1989 by Dr. Gabriel Serrano, a Valencia-based dermatologist who started the company after years of treating patients in his own clinic and finding that existing skincare products fell short of what he needed professionally. [1]

Where are Sesderma® Products Made? 

Sesderma® is manufactured at the company’s own facilities in Puzol, near Valencia, under EU cosmetic regulation. This answers the common question of where Sesderma® products are made: everything is produced in Spain, in-house, under the company’s direct oversight.

The company sits within Sesderma® Group S.L., which also owns MEDIDERMA, the group’s clinic-exclusive professional arm. Sesderma® products are now distributed in more than 80 countries, sold through aesthetic clinics, dermatologists, and other licensed medical professionals rather than general retail. [1]

Are Sesderma® and Mediderma® the Same? Clarifying the Brand Relationship

Both brands are not the same, but they are closely related. Both belong to Sesderma® Group S.L., founded by Dr. Gabriel Serrano, but Mediderma was launched a few years later, in 1993, as a separate, clinic-exclusive division. [2]

Mediderma products, including its peels, boosters, and professional devices, are formulated for in-practice use and sold only through licensed healthcare professionals. Sesderma, by contrast, spans both professional and consumer-facing channels, which is why you’ll see it stocked in clinics and also recommended for patients to continue using at home between visits. Practitioners choosing between the two can think of it this way: Mediderma handles the in-clinic procedure, and Sesderma® is what the patient takes home to maintain the result.

Sesderma® Liposomal and NANOPORE Technology – How to Purchase Sesderma® Online

Sesderma’s core differentiator is its liposomal Nanotech delivery platform. Liposomes are tiny phospholipid vesicles, roughly 100 to 400 nanometers across, that fuse with skin cell membranes and release their contents intracellularly rather than sitting on the surface waiting to be absorbed. This matters for actives that are notoriously unstable or poorly absorbed in conventional formulations. Vitamin C is the clearest example, along with azelaic acid and retinol. Encapsulating these actives in liposomes meaningfully improves how much of the ingredient actually reaches living skin cells instead of degrading in the jar or sitting inert on the surface. The broader nanotechnology approach behind these formulations has been central to the brand’s identity since it launched its first nanotechnology-based product lines in 2008. [3]

NANOPORE refers to Mediderma’s professional microneedling device family, including the NANOPORE Stylus and NANOPORE Pen. These devices create controlled micro-channels in the skin that improve penetration of topical actives applied immediately afterward. NANOPORE is not a separate delivery technology built into Sesderma’s topical products themselves, but the two technologies complement each other well in practice: a Mediderma NANOPORE session in clinic followed by Sesderma’s liposomal actives at home is a combination some practitioners already build into their protocols.

Is Sesderma® Medical Grade?

Sesderma® belongs to the cosmeceutical tier: formulations with higher active ingredient concentrations than standard drugstore products, sold through professional and clinical channels, and built around advanced delivery technology. It is not a pharmaceutical product and isn’t sold on prescription. Regulated as a cosmetic under the EU Cosmetics Regulation (EC) No 1223/2009, Sesderma® is best described as professional cosmeceutical skincare rather than a medical device or drug.

Sesderma® Product Range — Full Catalog

AZELAC® RU (Pigmentation)

Sesderma® AZELAC® RU LIPOSOMAL SERUM targets pigmentation, uneven tone, and post-inflammatory hyperpigmentation. The Sesderma® AZELAC RU serum combines a multi-ingredient depigmenting complex, with key actives including azelaic acid, tranexamic acid, 4-butylresorcinol, and niacinamide, delivered through Sesderma’s liposomal system for enhanced epidermal penetration. It is generally well tolerated on sensitive skin and remains one of the most consistently ordered products in the Sesderma® AZELAC line for pigmentation correction protocols.

Sesderma® AZELAC® RU LUMINOUS FLUID CREAM carries the same depigmenting complex as the serum but in a moisturizing facial cream gel base. Patients who prefer a cream texture or who have drier skin tend to do better with this format than the liquid serum.

C-VIT (Vitamin C and Antioxidant)

Sesderma® C-VIT LIPOSOMAL SERUM is the brand’s Sesderma® vitamin C antioxidant serum, using liposomal encapsulation to deliver more ascorbic acid into the skin than a conventional vitamin C formula typically manages. It addresses oxidative stress, dullness, and uneven tone, and functions as a facial serum in both brightening and anti-aging routines.

The Sesderma® C-VIT range also includes Sesderma® C-VIT MIST, an antioxidant vitamin C facial mist in a lighter, moisturizing spray format meant for a quick refresh rather than a full serum step. It is a popular choice post-procedure or as part of a daily top-up.

Sesderma® C-VIT RADIANCE GLOWING FLUID rounds out the line as a lightweight moisturizing fluid built around vitamin C for radiance and general skin luminosity. It is an antioxidant cream hybrid for patients who want daily brightening without a heavy texture.

FACTOR G RENEW (Growth Factor Anti-Ageing)

Sesderma® FACTOR G RENEW REJUVENATING CREAM uses growth factor technology to support skin regeneration, address lines and wrinkles, and help with loss of firmness. It is often positioned for mature skin or as part of a post-procedure regenerative skincare protocol.

HIDRADERM (Deep Hydration)

Sesderma® HIDRADERM HYAL FACIAL CREAM is a hyaluronic acid-based moisturizing facial cream built for intensive hydration and skin barrier support, suitable for dry, dehydrated, and sensitive skin. The wider Sesderma® HIDRADERM range, including Sesderma® HIDRADERM TRX, provides additional hydration options. HIDRADERM HYAL also pairs well as a topical maintenance product between injectable HA skinbooster sessions.

HIDRAVEN (Sensitive Skin Cleansing)

Sesderma® HIDRAVEN FOAMY SOAP-FREE CREAM is a gentle, soap-free cleanser designed for sensitive and reactive skin. The Sesderma® HIDRAVEN range is a safe default for skin that is prone to dryness or intolerance, and it works well across most cosmetic and post-procedure protocols where a gentle cleanse is needed.

REPASKIN (Sun Protection)

Sesderma® REPASKIN INVISIBLE FLUID SPF50+ is a broad-spectrum SPF50+ sunscreen in a lightweight, invisible fluid finish, built for daily photoprotection. Sesderma® REPASKIN is essential after laser treatments, peels, or any hyperpigmentation protocol where UV exposure could undo the work already done.

Clinical Applications — Fitting Sesderma® into Aesthetic Protocols

For pigmentation, AZELAC® RU Liposomal Serum paired with REPASKIN Invisible Fluid SPF50+ covers both correction and the daily photoprotection that pigmentation treatment absolutely depends on.

Post-procedure, HIDRAVEN Foamy Cream for gentle cleansing, REPASKIN SPF50+ for photoprotection, and FACTOR G RENEW for regeneration support form a reasonable default kit after laser treatments, peels, or microneedling.

As a complement to injectable HA work, HIDRADERM HYAL Facial Cream gives patients a topical hydration option to use between skinbooster sessions, keeping results looking fresher for longer.

For anti-aging protocols more broadly, Sesderma® RETI AGE and other Sesderma® retinol formulations, layered with C-VIT antioxidant serum and FACTOR G RENEW, form a fairly complete regimen. The wider catalog also includes eye contour treatments, limited edition antioxidant formulas, and the RETISIL INTENSIVE line. Practitioners who want to round out a protocol can also explore the Sesderma® SESLASH range for lash and brow conditioning, or the Sesderma® SALISES line for oily and acne-prone skin, both of which sit outside the core nine products covered above but see regular interest.

Sesderma® Compared to Other Professional Skincare Brands

vs Mediderma: Are They the Same Brand?

They only share the same founder and parent group, but they are not the same. Mediderma is the clinic-exclusive professional arm, formulated for in-practice protocols and sold only through licensed healthcare professionals. Sesderma® spans both professional and consumer-accessible channels. Some practitioners describe Mediderma as the clinic-only version and Sesderma® as the professional retail version of the same underlying philosophy.

vs Mesoestetic®

Mesoestetic®, also based in Spain, in Barcelona, is arguably the more established medical-grade brand in the Spanish professional skincare market, with a stronger foothold in dermatology clinics and a more extensively published clinical evidence base. Its Cosmedical range is positioned firmly at the prescription-adjacent end of professional skincare. Sesderma® plays across a broader professional-to-consumer spectrum, with liposomal delivery technology as its main point of difference. Mesoestetic®’s brightening lines, Mesoprotech and Meso White, compete directly with Sesderma’s AZELAC® RU in the pigmentation space, and its radiance DNA fluid sits in the same category as Sesderma’s C-VIT range. Where Sesderma® pulls ahead is its delivery technology story; where Mesoestetic® pulls ahead is depth of published clinical evidence.

vs Plinest®

Plinest®, made by Mastelli in Italy, is a polynucleotide (PDRN) injectable, a completely different product category from Sesderma’s topical skincare. Plinest® works through injectable biostimulation, while Sesderma® is applied topically. The two are not really competitors so much as potential partners in the same protocol: a practitioner running Plinest® injectables can complement the treatment with Sesderma® topicals, particularly REPASKIN SPF50+ post-procedure, HIDRADERM HYAL for barrier support, and C-VIT antioxidant serum for ongoing skin health between sessions.

vs BCN (Institut BCN)

Institut BCN, based in Barcelona, is primarily a mesotherapy brand, built around injectable cocktails rather than topical skincare, with its own topical offering playing a secondary role. Sesderma® sits entirely in the topical category. The comparison matters most for clinics building a complete protocol: BCN’s injectable mesotherapy alongside Sesderma’s topical maintenance is a complementary pairing rather than a head-to-head choice.

vs FILLMED®

FILLMED®, part of the Filorga group in France, positions itself around professional injectables and mesotherapy, with its NCTF range of nutritive cocktails as the flagship product. Its topical line sits more in the premium consumer space than the clinical professional tier Sesderma® occupies. FILLMED® has strong recognition among injectors specifically, while Sesderma’s advantage is the sheer breadth of its topical range: pigmentation, Sesderma® vitamin C, SPF, hydration, and retinol all under one brand, with liposomal delivery technology as a clear differentiator.

For practitioners evaluating where to buy Sesderma® online, the single-brand protocol depth is often what tips the decision compared to sourcing Fillmed topicals separately from its injectable line.

Why Practitioners Choose Sesderma® — Key Benefits

The liposomal delivery system is the main reason most practitioners stock Sesderma. For actives like vitamin C and retinol, which are genuinely difficult to stabilize and deliver effectively in conventional formulations, the difference in bioavailability is clinically meaningful, not just a marketing claim.

The range itself is broad enough to run a single-brand protocol covering pigmentation, antioxidant care, anti-aging, hydration, cleansing, and sun protection without needing to source multiple manufacturers. In our experience, clinics that consolidate on one professional skincare line tend to see stronger patient compliance with take-home protocols, partly because staff become more fluent recommending products they know well.

Manufacturing in Spain under EU cosmetics regulation also means no cold-chain requirements and a stable shelf life, which simplifies stock management considerably compared to some injectable or biologic product lines.

Safety and Tolerability

Sesderma® products are manufactured in the EU and safety-assessed under Regulation (EC) No 1223/2009. Liposomal formulations are generally well tolerated across skin types. The AZELAC® RU range should be avoided in patients with known azelaic acid sensitivity. Any retinol-based product in the range, including Sesderma® RETI AGE, should be avoided during pregnancy, introduced gradually, and always paired with daily SPF. Sesderma® products are not tested on animals.

Category-specific products like Sesderma® shampoo, the Sesderma® NANOCARE intimate range, and the Sesderma® SALISES line each have their own tolerability guidance detailed in each product’s individual instructions for use.

Buy Sesderma® Wholesale — Doctor Medica

Buy Sesderma® from Doctor Medica today. We sell Sesderma® professional skincare directly to licensed aesthetic practitioners at wholesale prices, and we have done so for more than 15 years alongside our full range of professional skincare and injectables.

For clinics wondering where to buy Sesderma® in the USA, Doctor Medica can assist licensed professionals without the sourcing guesswork, whether that is a single product or a full range refresh for the clinic. We offer verified products, competitive pricing, and reliable shipping on every order. Practitioners who want to buy Sesderma® products for their clinics can also reach out for information on shipping timelines and volume pricing.

Frequently Asked Questions

What is Sesderma®?

Sesderma® is a professional skincare brand founded in 1989 in Valencia, Spain, built around proprietary liposomal and nanotechnology delivery systems. Its ranges cover pigmentation, vitamin C, anti-aging, hydration, sun protection, retinol, and sensitive skin.

Where are Sesderma® products made?

All Sesderma® products are manufactured in-house in Valencia, Spain, under EU cosmetic regulations, including Regulation (EC) No 1223/2009.

Is Sesderma® medical grade?

Sesderma® sits in the cosmeceutical professional tier, formulated with higher active concentrations and advanced delivery technology, but it is not a pharmaceutical product. It is sold through clinics, dermatologists, and aesthetic practitioners rather than on prescription.

Are Sesderma® and Mediderma® the same?

They are connected, but distinct brands under Sesderma® Group S.L. Mediderma® is the clinic-exclusive professional division, formulated for in-practice use. Sesderma® covers a broader professional and consumer skincare portfolio under the same parent company.

What is Sesderma® Liposomal Technology?

Sesderma® uses liposomal encapsulation, phospholipid vesicles that fuse with skin cell membranes and release actives intracellularly, to improve the stability, penetration, and bioavailability of ingredients like vitamin C, azelaic acid, and retinol.

What is Sesderma® AZELAC® RU?

AZELAC® RU is Sesderma®’s pigmentation-focused range, built around a multi-ingredient depigmenting complex that includes azelaic acid, tranexamic acid, 4-butylresorcinol, and niacinamide. It is available as a liposomal serum and a luminous fluid cream for addressing uneven tone, post-inflammatory hyperpigmentation, and melasma.

Where can practitioners buy Sesderma® products in the USA?

Licensed practitioners can buy Sesderma® wholesale through Doctor Medica. Browse the available range above or contact the team for verified products, wholesale pricing, bulk orders, and shipping information.

For licensed medical professionals only. This content is for informational purposes only and does not constitute medical advice.

Citations and Resources

[1] Sesderma. “About Us.” Sesderma.

[2] Sesderma Academy. “About Us.” Sesderma Academy.

[3] Joseph, Sarah. “How Sesderma Became the Pioneers in Nanotechnology with Its Effective Skincare Products.” Emirates Woman, 9 Aug. 2023, emirateswoman.com/how-sesderma-became-the-pioneers-in-nanotechnology-with-its-effective-skincare-products/.

[4] Weaver, James. “Sesderma: Defining Tomorrow’s Skin Health with Precision Innovation.” Success Knocks, 22 Dec. 2025, successknocks.com/sesderma-dr-gabriel-serrano/.