FILLMED® NANOSOFT®: Use Cases and Expectations

FILLMED® NANOSOFT® is a single-use microneedle device for mesotherapy that places active solutions into the dermis through three tiny silicon points instead of a conventional steel needle. For clinicians evaluating intradermal delivery options, Doctor Medica examines FILLMED® NANOSOFT® and its applications in skin-quality treatments. Clinics researching where to buy FILLMED® online can also use this guide to assess how the device fits into protocols involving NCTF® 135 HA.

This article will explore how the device is built, what comes in the kit, which areas it suits best, what results and side effects to expect, and how it stacks up against other delivery methods.

Key Takeaways

• NANOSOFT® uses three hollow 0.6 mm silicon microneedles to standardize intradermal depth, and FILLMED® describes the needle head as around three times smaller than a standard injection needle.
• The device is paired mainly with NCTF® 135 HA for fine lines and thin-skinned zones such as crow’s feet, eyelids, and the neck.
• A randomized split face/neck study reported better performance with NANOSOFT® than with a classic 32G needle, with the size of the advantage varying by skin zone and thickness.

About: Doctor Medica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices in the market. If you’re looking to buy FILLMED® for your practice, contact Doctor Medica today.

What Is FILLMED® NANOSOFT®?

NANOSOFT® is an intradermal injection device that attaches to a standard syringe in place of a conventional mesotherapy needle [4]. The technology was developed by NanoPass Technologies, an Israeli microneedle specialist, and introduced to aesthetic medicine through a co-branding agreement with FILLMED®. The device was presented at AMWC in Monaco in April 2019, ahead of its European launch in May [3].

NANOSOFT® does not contain an active ingredient. Instead, it facilitates shallow intradermal delivery of compatible injectable solutions, including NCTF® 135 HA, which is used in skin revitalization protocols addressing fine lines and skin quality [3][4]. NCTF® 135 HA combines 59 nutritive ingredients with non-cross-linked hyaluronic acid at a 5 mg/mL concentration [2].

The device’s short, fixed-length microneedles are designed to reduce variability in injection depth compared with conventional mesotherapy needles.

What Makes the NANOSOFT® Needle Different?

The difference is scale and material. Each NANOSOFT® head carries three hollow, pyramid-shaped microneedles, each 0.6 mm long, produced from silicon crystal using MEMS (micro-electro-mechanical systems) manufacturing [1][3].

FILLMED® describes NANOSOFT® as approximately three times smaller than a conventional injection needle [4], although its product description does not specify the measurement used for that comparison. The device’s three microneedles are each 0.6 mm long, compared with the 4 mm conventional needle used in the published comparative study [1]. Needle length and the manufacturer’s general size comparison should therefore be understood as separate specifications.

That design brings precision and medical-grade consistency in several ways:

• Fixed depth. The 0.6 mm microneedles are designed for controlled, shallow intradermal delivery. Their fixed length helps standardize placement, although actual injection depth still depends on technique and local skin anatomy [1][3].
• Standardized papules. Each point produces a consistent papule, which supports an even injection depth from head to head [4].
• Universal fit. The head is single-use and adapts to all standard syringes [4].

What Does the FILLMED® NANOSOFT® Injecting Kit Include?

FILLMED® NANOSOFT® is supplied in a dispenser containing 30 sterile, single-use devices [7]. Each device has three 0.6 mm microneedles and is discarded after use.

The kit is deliberately minimal. The practitioner supplies:

• The active solution. NCTF® 135 HA, drawn into the syringe before the NANOSOFT® head is attached [1].
• A syringe. FILLMED®’s registered study used a 3 mL sterile syringe for solution delivery [1].
• Skin preparation. The study protocol disinfected the treated area with chlorhexidine before injection [1].

Each treatment also involves a disposable device cost in addition to the injectable solution and other consumables. Clinics should account for these costs when estimating treatment pricing, as distributor prices and packaging options may vary.

What Are the Clinical Use Cases for FILLMED® NANOSOFT®?

FILLMED®’s own product materials consistently name the same core zones [4]:

• Periorbital area. FILLMED® NANOSOFT® eye treatment covers the eyelids and crow’s feet, where a shallow, even depth matters most.
• Neck and décolleté. The device is positioned specifically for the neck, where good results can be achieved on tissue that tolerates classic needles poorly.
• Fine lines across the face. The launch program framed NANOSOFT® around smoothing fine lines and redensifying thin skin [3].

Within a broader FILLMED® treatment plan, SKIN PERFUSION may serve a separate topical-care role before or after aesthetic procedures. It is not an injectable solution administered through NANOSOFT®.

What Clinical Results Have Been Reported With FILLMED® NANOSOFT®?

Clinical outcomes involving NANOSOFT® should be distinguished from those attributable to the injected solution. In a randomized study involving 146 participants, NCTF® 135 HA injections combined with moisturizer improved superficial wrinkles and facial radiance compared with moisturizer alone [2]. However, that trial assessed NCTF® 135 HA rather than the NANOSOFT® delivery device itself.

Device-specific evidence comes from a randomized split-face and neck study involving 40 participants. Researchers compared NANOSOFT® with a conventional 32G × 4 mm needle for delivery of NCTF® 135 HA. The NANOSOFT® side showed statistically significant advantages for selected wrinkle, hydration, and radiance measurements, with the magnitude and timing of improvements varying across treatment areas [1]. The findings support potential benefits from the delivery method but do not establish superiority for every clinical endpoint.

What patients typically notice:

• Brighter, smoother skin with improved radiance after a course of sessions [2].
• Lower average injection-pain scores than conventional needles were reported in the comparative study [1].
• Short-lived papules at the injection points. FILLMED®’s materials describe these as resolving within about 24 hours as the solution spreads [4].

Both clinical studies discussed here evaluated treatment over multiple sessions [1][2]. Their reported outcomes should not be interpreted as guaranteed results after a single appointment.

What Are the Potential Side Effects or Drawbacks?

NANOSOFT® is designed to reduce injection-related discomfort and local reactions, but it does not eliminate procedural risks. In the comparative clinical study, adverse events were generally milder with the microneedle device than with conventional needles [1]. Redness, swelling, bruising, or local sensitivity may occur following intradermal injection.

The practical drawbacks worth weighing:

• Fixed shallow depth. At 0.6 mm, the device cannot place product in deeper planes [3], so it does not replace needles or cannulas for volumizing work.
• Consumable cost. Each patient needs a new device, which adds a per-session cost on top of the solution [4].
• Solution-specific positioning. The product literature presents NANOSOFT® for intradermal delivery of solutions such as NCTF® 135 HA, not as a universal mesotherapy platform [4].

How Does FILLMED® NANOSOFT® Compare With Other Delivery Methods?

The main alternatives differ in mechanism more than in brand:

Delivery method	How it works	Depth control	Main trade-off
FILLMED® NANOSOFT®	Three 0.6 mm hollow silicon microneedles attached to a standard syringe [3][4]	Fixed by needle length	Shallow placement only; cannot volumize
Classic mesotherapy needle	A single steel needle such as a 32G × 4 mm [1]	Set by the injector’s hand and angle	Less consistent depth in FILLMED®’s split study [1]
Microneedling pen or roller	Creates channels in the skin; topical products may be applied separately	Depends on device configuration	Does not provide the same direct intradermal injection mechanism as NANOSOFT®

The headline difference for a FILLMED® clinic is integration: NANOSOFT® is packaged and trained as part of the NCTF® protocol. Unlike a FILLMED® filler such as ART FILLER®, which is placed deeper with conventional needles or cannulas, NANOSOFT® is a skin-quality tool rather than a volumizer [3][4].

What Do Clinical Evidence and Practitioner Experience Suggest About NANOSOFT®?

Published practitioner experience with NANOSOFT® has emphasized injection comfort and its use in delicate areas, particularly around the eyes and neck [6]. These observations are consistent with some findings from the later comparative study [1], although individual clinical experience should not be treated as equivalent to controlled evidence.

NANOSOFT® also received the Best Aesthetic Device award at AMWC 2023 [5]. Its practical limitations remain relevant: the device is intended for shallow intradermal delivery, and each single-use head adds a consumable cost to treatment planning.

When considering broader FILLMED® testimonials, clinicians should distinguish experiences with NANOSOFT® from those involving the company’s injectable formulations and skincare products.

Looking to buy FILLMED® NANOSOFT® online? Get in touch with our customer service representatives at Doctor Medica for further guidance.

For licensed medical professionals only. This content is for informational purposes only and does not constitute medical advice.

Citations

[1] Boca, Andreea et al. “Evaluation of the Performance and Safety of a New Micro-Needle Technology in Comparison With the Classic Needle on the Antiaging Effects of a Biorevitalizing Solution: A Randomized Split Face/Neck Study.” Journal of cosmetic dermatology vol. 23,12 (2024): 3974-3985. doi:10.1111/jocd.16547

[2] Fanian, Ferial et al. “A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study.” The Journal of dermatological treatment vol. 34,1 (2023): 2216323. doi:10.1080/09546634.2023.2216323

[3] NanoPass Technologies Ltd. “FILLMED and NanoPass Launch NANOSOFT™ Microneedles for Aesthetics.” PR Newswire, 3 Apr. 2019, www.prnewswire.com/il/news-releases/fillmed-and-nanopass-launch-nanosoft-tm-microneedles-for-aesthetics-855536718.html.

[4] FILLMED. “New Products NANOSOFT®.” FILLMED, fillmed.com/new-products-nanosoft/.

[5] FILLMED. “AMWC 2023 Aesthetic Medicine Awards.” FILLMED, 2023, fillmed.com/amwc-2023-aesthetic-medicine-awards/.

[6] Smit, Riekie. “New: Nanosoft™.” Anti Age and Longevity Magazine, 1 Apr. 2019, en.anti-age-magazine.com/nanosoft-aesthetic-medicine-revolution/.

[7] FILLMED. “Treatment Protocols: To Precisely Target Indications.” FILLMED, uk.fillmed.com/wp-content/uploads/2024/03/FIL7261-Treatment-Protocols-Practitioner-Brochure-single-page.pdf.