BELOTERO® REVIVE

BELOTERO® REVIVE is an injectable skin revitalizer combining 20 mg/mL of cross-linked sodium hyaluronate with 17.5 mg/mL of glycerol, designed to treat early signs of photodamaged facial skin. Utilizing Cohesive Polydensified Matrix (CPM®) technology, it integrates smoothly into the dermis, enhancing hydration, elasticity, and firmness while reducing superficial fine lines and skin roughness.

BELOTERO® REVIVE should be administered by trained healthcare professionals under appropriate aseptic conditions.

Key Features:

• Injection depth: Mid to deep dermis
  
• Needle size: Typically 30G½” needles
  

Protocol Details:

• Injection techniques: Linear threading, serial puncture, fanning, or cross-hatching
  
• Volume per session: Varies based on treatment area and desired correction
  
• Treatment regimen: 1 to 3 sessions, with at least 4 weeks between sessions; maximum annual dose of 24 mL
  
• Post-injection care: Gentle massage to ensure even distribution

Indications:

• Early signs of photodamaged facial skin, characterized by:
  
  • Dehydration
    
  • Superficial fine lines
    
  • Loss of elasticity and firmness
    

Contraindications:

• Hypersensitivity to any components (sodium hyaluronate, glycerol, BDDE)
  
• Pregnancy or breastfeeding
  
• Patients under 18 years old
  
• Active infections or inflammation at the injection site
  
• Autoimmune diseases
  
• Previous treatment with permanent dermal fillers in the target area
  

Side Effects:

• Common: Redness, swelling, bruising, tenderness, itching
  
• Rare: Nodules, granulomas, discoloration, vascular occlusion

Each 1 mL syringe contains:

• Cross-linked sodium hyaluronate: 20 mg/mL
  
• Glycerol: 17.5 mg/mL
  
• Phosphate buffer: pH 7

Package Contents:

• 1 pre-filled syringe (1 mL)
  
• 2 sterile 30G½” needles
  
• Package insert with detailed instructions
• 2 traceability labels for product verification

While generally well-tolerated, BELOTERO® REVIVE may cause side effects.

Common Side Effects:

• Injection site reactions: Redness, swelling, bruising, tenderness, itching
  
• Duration: Typically resolve within 1 to 2 weeks
  

Rare Side Effects:

• Nodules or granulomas
  
• Discoloration
  
• Vascular occlusion, leading to more serious complications

Storage Conditions:

• Temperature: Store between 2°C and 25°C
  
• Avoid: Freezing and exposure to direct sunlight
  
• Packaging: Keep in original packaging until use
  
• Shelf life: Do not use beyond the expiration date indicated on the packaging