Mastelli Plinest – All About the Italian Manufacturer

Founded in 1952 in Sanremo, Italy, Mastelli has long been at the forefront of skincare and regenerative medicine, establishing itself as a leader in the field. With a deep commitment to advancing healthcare, Mastelli specializes in developing and producing a wide range of products, including drugs, medical devices, dermocosmetics, and food supplements.

Among its most notable innovations is the Plinest line, a collection of dermocosmetic products designed to enhance outpatient treatments. These products are carefully formulated with functional ingredients and excipients that stand out for their unique characteristics, ensuring both safety and efficacy, even for patients undergoing pharmacological treatments.

In this article, we’ll explore Mastelli’s rich history, its unwavering commitment to innovation, and the development of the Plinest line. We’ll also dive into the company’s manufacturing processes, focus on quality and safety, and examine the profound impact its products have had on the field of aesthetic medicine.

Key Takeaways

• Mastelli has over seven decades of experience in pharmaceutical innovation, specializing in biologics, natural extracts, and dermatological products.
• The company’s PN-HPT™ technology is at the heart of its regenerative medicine approach, allowing the extraction and purification of polynucleotides for skin rejuvenation and tissue repair.
• Plinest, the flagship product, uses PN-HPT™ polynucleotides to enhance skin elasticity and texture, making it ideal for treating areas with acne scars, dark circles, and fine lines.
• Mastelli’s product line includes Plinest Eye, Plinest Hair, Plinest Fast, Plinest One, Newest®, and Newest® One, all designed to address a wide range of aesthetic concerns, from skin laxity to scarring and hair rejuvenation.
• Mastelli maintains a strong commitment to clinical research, regulatory compliance, and safety, ensuring that all products meet the highest standards for quality and performance.
• The company has a global presence, with distribution across Europe, Asia, the Middle East, and the Americas, and provides comprehensive training and educational resources for healthcare professionals.

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Company Background and Expertise

Founded in Sanremo, Italy, Mastelli has over seven decades of experience in pharmaceutical innovation. The company specializes in the development and production of biologics, natural extracts, and a wide range of products, with a strong focus on dermatology, aesthetic medicine, and wound healing. Mastelli’s commitment to research and development has led to the creation of groundbreaking therapies, particularly in the realm of polynucleotide-based treatments.

Mastelli’s expertise lies in the extraction and purification of DNA-derived molecules, specifically polydeoxyribonucleotide (PDRN) and polynucleotides (PN). These substances are known for their regenerative properties, making them ideal for applications in skin rejuvenation and tissue repair. By maintaining complete control over the supply chain, Mastelli ensures the highest quality standards, delivering safe and effective products to its global market.

PN-HPT™ Technology and Product Line

At the heart of Mastelli’s innovative approach to regenerative medicine is its proprietary PN-HPT™ technology. This cutting-edge process involves the meticulous extraction and purification of polynucleotides from natural biological sources, such as trout sperm DNA. The result is an exceptionally pure and safe compound that maximizes therapeutic benefits while minimizing potential impurities or adverse effects.

• Plinest: Aimed at maintaining youthful skin and remodeling fibrous areas like acne scars. It enhances elasticity and texture for both preventative and corrective treatments.
• Plinest Eye: Specially designed for the delicate eye area. Plinest Eye targets fine lines, dark circles, and puffiness, improving skin texture and firmness.
• Plinest Hair: Stimulates hair and eyebrow rejuvenation, promoting healthier follicles, improving scalp health, and potentially reducing hair thinning and loss.
• Plinest Fast: Ideal for sensitive skin, it delivers quick hydration and regeneration with minimal irritation, perfect for post-procedure care.
• Plinest One: Designed for younger patients with early skin laxity, it helps prevent sagging and improves skin tone by boosting fibroblast activity.
• Newest: Combines PN-HPT™ and hyaluronic acid for mature, dehydrated skin, enhancing hydration, skin plumpness, and remodeling of scars and stretch marks.
• Newest One: Targets severe atrophic scars, stretch marks, and blemishes, promoting intensive skin remodeling and improved texture and resilience.

Each of these products is designed to complement and synergize with other aesthetic treatments. When used in conjunction with modalities such as laser therapy, radiofrequency, dermal fillers, and microneedling, Mastelli’s polynucleotide-based products enhance overall outcomes by accelerating tissue healing, improving skin quality, and extending the longevity of results. This multi-modal approach ensures patients receive comprehensive care that maximizes rejuvenation effects across different skin types and concerns.

Clinical Research and Regulatory Compliance

Mastelli places a strong emphasis on clinical research to validate the efficacy and safety of its products. The company collaborates with academic institutions and medical professionals to conduct rigorous studies. This helps ensure their products meet the highest standards of quality and performance.

All of Mastelli’s medical devices are CE-certified, complying with European Union regulations for safety and effectiveness. The company’s manufacturing processes adhere to Good Manufacturing Practices (GMP) and ISO standards, reflecting its commitment to excellence in pharmaceutical production.

By investing in ongoing research and maintaining strict regulatory compliance, Mastelli continues to advance the field of regenerative medicine. By offering innovative solutions, they are able to improve patient outcomes.

Global Presence and Professional Support

Mastelli’s products are distributed internationally, reaching markets across Europe, Asia, the Middle East, and the Americas. The company’s global presence is a testament to the trust and recognition it has earned within the medical community.

To support healthcare professionals, Mastelli provides comprehensive training and educational resources. The company organizes workshops, seminars, and participates in medical conferences to share knowledge and best practices. This commitment to professional development ensures that practitioners are well-equipped to deliver optimal patient care using Mastelli’s products.

For those interested in comparing Mastelli’s offerings with other products in the market, exploring the differences between similar treatments like Plinest vs Nucleofill can provide valuable insights into their respective benefits and applications.

Conclusion

Mastelli is a pioneer in regenerative and aesthetic medicine, known for its decades-long commitment to pharmaceutical innovation and quality. Founded in Italy, the company has established itself as a trusted name in dermatology and skin rejuvenation. As the original Plinest manufacturer, Mastelli has leveraged its scientific expertise to develop advanced biotechnological solutions. With their products, they utilize highly purified polynucleotides for skin and tissue regeneration.

At the core of Mastelli’s success is its proprietary PN-HPT™ technology. This ensures the safety, purity, and effectiveness of its products. Their commitment to safe and effective aesthetic solutions is further reflected in the company’s investment in clinical research, compliance with strict European regulatory standards, and global presence across major aesthetic markets. By integrating science, safety, and innovation, Mastelli continues to lead the way in modern skincare therapies and aesthetic advancements.

FAQs

1. What is PN-HPT™ technology?

PN-HPT™ (Polynucleotides High Purification Technology) is Mastelli’s proprietary method for extracting highly purified polynucleotides from natural sources. This technology ensures the safety and efficacy of their products by eliminating impurities and enhancing the regenerative properties of the polynucleotides.

2. How does Plinest differ from Newest?

Plinest helps maintain youthful skin and remodel areas with high fibrous content, such as acne scars. Newest combines polynucleotides with hyaluronic acid, making it ideal for mature and dehydrated skin, promoting remodeling of striae distensae and improving skin trophism.

3. Do Mastelli products have CE certification?

Yes, all of Mastelli’s medical devices are CE-certified, indicating compliance with European Union regulations for safety and effectiveness. The company also adheres to Good Manufacturing Practices (GMP) and ISO standards.

4.  Where can I purchase Mastelli’s products?

Mastelli’s products are available through authorized distributors and medical suppliers worldwide. For more information on purchasing options, you can visit their official website or contact their customer support for assistance.

References

Mastelli S.r.l. Officina Bio-Farmaceutica. The company overview. Mastelli website. Accessed June 3, 2025. https://www.mastelli.com/company 

Lee KWA, Chan KWL, Lee A, et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. Int J Mol Sci. 2024;25(15):8224. Published 2024 Jul 27. doi:10.3390/ijms25158224