Profhilo vs Rejuran – Comparing Treatments

Dermal filler treatments have continued to rise in popularity, with over 6 million procedures performed in the United States alone in 2023, according to the American Society of Plastic Surgeons (ASPS). These non-surgical treatments are sought after for their ability to rejuvenate the skin and restore a youthful appearance with minimal downtime.

Two standout treatments in this category are Profhilo and Rejuran. Profhilo is known for its deep hydration and skin remodeling properties, while Rejuran, often called a “skin healer,” is prized for its regenerative effects and ability to improve skin texture and elasticity.

In this article, we will compare Profhilo and Rejuran, exploring their benefits and differences and how they can help you achieve your skincare goals.

Key Takeaways

• Profhilo and Rejuran help make skin look younger but work in different ways. Profhilo uses hyaluronic acid to hydrate and tighten the skin, while Rejuran uses salmon DNA to fix scars and tiny pores.
• Treatments with Profhilo involve two sessions a month apart for effects lasting six months. Rejuran requires three sessions a month apart, with results improving over time.
• Both treatments show strong support from clinical studies. Patients say their skin feels better after using them, noting less pain and quick recovery times.
• The choice between Profhilo and Rejuran depends on your skin’s needs. If you want to target aging signs like loose skin or want deep hydration without added volume, go for Profhilo. Choose Rejuran if you’re trying to repair scars or reduce pore size through a collagen boost without affecting elastin production.

About: Doctor Medica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices in the market. If you’re looking to buy Profhilo for your practice, contact the Doctor Medica today.

Introduction to Profhilo and Rejuran

Profhilo is a hyaluronic acid-based treatment designed to deeply hydrate and remodel the skin. Unlike traditional fillers, it doesn’t add volume but instead enhances skin quality by boosting hydration, improving elasticity, and stimulating collagen production, resulting in a smoother, firmer complexion.

Rejuran, also known as Rejuran Healer, is a polynucleotide (PN) treatment focusing on skin regeneration. Derived from salmon DNA, Rejuran promotes cell repair and rejuvenation, making it highly effective for improving skin texture, reducing fine lines, and enhancing overall skin health.

Composition and Mechanism of Action

Profhilo combines 32 mg each of high- and low-molecular-weight hyaluronic acid. This blend deeply hydrates the skin and enhances elasticity, stimulating collagen and elastin production. The treatment uses the Bio Aesthetic Points (BAP) technique, targeting five injection points per side of the face for even distribution and effective skin rejuvenation.

Meanwhile, Rejuran is formulated with polynucleotides (PN) derived from salmon DNA, which are highly compatible with human skin. These polynucleotides promote collagen production, tissue regeneration, and skin repair. Administered in three sessions spaced a month apart, Rejuran effectively improves skin texture, reduces fine lines, and supports overall skin rejuvenation.

Clinical Efficacy and Specific Skin Concerns

Profhilo

Clinical studies have shown remarkable results for Profhilo treatments, emphasizing their power to rejuvenate the skin. These studies highlight Profhilo’s ability to stimulate collagen and elastin production, which is crucial for combating signs of aging.

• Firming the Skin: Profhilo’s formula helps the skin feel tightened and stiffer, battling loose areas that frequently appear with aging.
• Skin Hydration: Profhilo moisturizes the surface and enhances moisture retention over time for enduring hydration.
• Anti-Aging: Profhilo directly confronts various signs of aging, reverting the skin’s appearance.
• Skin Rejuvenation: It revives skin at the cellular level, leaving skin glowing and radiant.
• Skin Aging: This therapy directly tackles fine lines and wrinkles by lessening the skin’s natural repair mechanisms.
• Wrinkle Reduction: Profhilo softens wrinkles, offering a smoother texture and diminishing aging signs.

Rejuran

Clinical studies have shown Rejuran’s effectiveness in enhancing skin appearance and repairing acne scars. These findings highlight its role in promoting collagen production and skin repair.

• Acne Scar Treatment: It stands out for its efficacy in repairing scars. Rejuran fills in the scars from within by inducing collagen synthesis, smoothing out the skin’s surface.
• Pore Minimization: Rejuran will help those struggling with large pores. The treatment tightens the skin and reduces the appearance of pores by enhancing the skin’s texture and firmness.
• Collagen Induction Therapy: This is central to Rejuran’s action, rejuvenating the skin by increasing collagen production. More collagen means firmer, plumper skin that looks more youthful.
• Skin Repair: Beyond cosmetic improvements, Rejuran helps in overall skin repair. It strengthens the skin’s barrier and enhances resilience against environmental damage.
• Wrinkle Reduction: Fine lines and wrinkles can be reduced with Rejuran treatments as well. The boost in collagen smooths out these signs of aging for a more refreshed look.

Longevity of Results and Side Effects

Profhilo delivers long-lasting results, typically around six months after two sessions are completed within one month. The treatment is well-tolerated, with minimal discomfort and downtime. However, it may cause the following side effects:

• Mild Pain: Some discomfort may be felt during injections.
• Soreness and Inflammation: For a few days, the treated areas, especially those around the Profhilo injection points, may be tender and slightly inflamed.
• Redness and Bruising: Temporary redness and occasional bruising may occur at the injection sites.
• Allergic Reactions: Uncommon but possible, including symptoms like redness and itching.
• Nerve Damage: Rare and usually temporary if it occurs.
• Infection: A small risk exists, which can be minimized with proper care.

As for Rejuran, three sessions are spaced one month apart, with results emerging after the third or fourth treatment. It is effective for enhancing skin elasticity and collagen production. However, it may cause the following side effects:

• Swelling and Redness: Mild swelling and redness are typical, usually resolving within 48 hours.
• Injection Marks: Visible marks can last up to five days before fading.
• Allergic Reactions: Extremely rare but can include redness, swelling, or itching.
• Infection: A low risk that is minimized with proper aftercare.
• Increased Sensitivity: Temporary tenderness in the treated area may occur.

Practical Considerations and Comparison

Profhilo and Rejuran are both effective skin rejuvenation treatments, each with its own approach and protocol. Profhilo uses the Bio Aesthetic Points (BAP) injection technique, requiring just two sessions spaced one month apart. This method ensures even product distribution with minimal downtime and discomfort.

• Start with a consultation to evaluate the patient’s skin and determine if Profhilo is suitable. Discuss expected outcomes and potential side effects.
• During each session, apply the BAP technique, using five injection points per side of the face for optimal results.

Rejuran is well-regarded for repairing acne scars, reducing large pores, and improving overall skin texture. Its efficacy depends on following a structured treatment plan.

• Schedule three Rejuran sessions at one-month intervals to allow the skin to heal and absorb the treatment fully.
• Choose Rejuran S for deeper scars or more severe skin issues, and Rejuran Healer for general skin rejuvenation.

Patients typically notice significant improvements after completing the three Rejuran sessions, thanks to enhanced collagen production and skin repair.

When comparing Profhilo and Rejuran, both treatments are highly effective but differ in approach, protocol, and cost. Medical professionals should consider these factors when determining which treatment best fits the patient’s needs and the practice’s budget.

Cost and Affordability

Profhilo treatments typically cost $500 to $700 per session, with two sessions required for optimal results. Factors influencing the cost include the practitioner’s expertise, clinic location, and the specific needs of the patient’s skin.

Rejuran treatments generally cost between $300 and $600 per session, with three sessions recommended for best outcomes. The cost can vary based on the type of Rejuran used (Rejuran S or Rejuran Healer), the severity of the skin condition, and the clinic’s pricing structure.

When considering affordability, patients should weigh the total cost of the treatment series and the longevity of the results. While Profhilo may have a higher upfront cost, its effects last longer, potentially offering better value over time. Rejuran, with its lower per-session cost, might be more accessible for those seeking gradual improvements. 

Conclusion

Choosing between Profhilo and Rejuran ultimately depends on your skin concerns and goals. 

Profhilo is ideal for addressing skin laxity and signs of aging. It uses a unique blend of hyaluronic acid to boost collagen, enhance elasticity, and deliver a plump, youthful appearance without adding volume.

On the other hand, Rejuran focuses on healing and rejuvenating the skin from within, utilizing salmon DNA to effectively treat scars, large pores, and overall skin texture.

While both treatments offer significant rejuvenation benefits, they differ in their ingredients, approach, and cost. Making an informed decision based on these factors will help you achieve the best possible results for your skin.

FAQs

1. What are the Profhilo and Rejuran treatments?

Profhilo and Rejuran are skin rejuvenation treatments, but they work in different ways to achieve results.

2. How do Profhilo and Rejuran compare rejuvenation benefits for skin revitalization?

The main difference lies in their composition—Profhilo is based on hyaluronic acid, while Rejuran uses PDRN derived from salmon DNA.

3. Which treatment is better: Profhilo or Rejuran?

The effectiveness of either treatment depends on individual needs. If hydration and firming up of sagging skin are your priorities, Profhilo could be a good fit; if healing acne scars or improving overall skin health is your goal, Rejuran could be a good fit.

4. Are there any side effects with these treatments?

Like all medical procedures, potential side effects exist for both treatments – including temporary swelling or bruising at injection sites. Discussing these possibilities with a certified professional before deciding on a treatment plan is crucial.

References

2023 Plastic Surgery Statistics Report. American Society of Plastic Surgeons. https://www.plasticsurgery.org/documents/news/statistics/2023/plastic-surgery-statistics-report-2023.pdf

Cassuto, D., Delledonne, M., Zaccaria, G., Illiano, I., Giori, A. M., & Bellia, G. (2020). Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. BioMed research international, 2020, 8159047. https://doi.org/10.1155/2020/8159047

Sparavigna, A., Grimolizzi, F., Cigni, C., Lualdi, R., & Bellia, G. (2024). Efficacy and tolerability of Profhilo® Structura intended to restore lateral cheek fat compartment: An observational pilot study. Health science reports, 7(1), e1743. https://doi.org/10.1002/hsr2.1743