HYAFILIA® GRAND PLUS with Lidocaine

HYAFILIA® GRAND PLUS with Lidocaine is a high-viscosity, cross-linked hyaluronic acid (HA) dermal filler designed for the deep dermis and subcutaneous tissue, delivering structural volume and contour enhancement. Its formulation is stabilized using 1,4-butanediol diglycidyl ether (BDDE), ensuring prolonged effect and biocompatibility. This product is indicated for the temporary improvement of deep facial wrinkles and volume loss, especially in areas such as the cheeks, jawline, and chin. With particle sizes reaching 1,100 µm, HYAFILIA® GRAND PLUS is ideal for creating definition and lift in more demanding facial zones.

It is a non-animal derived, colorless, transparent, viscoelastic gel that provides a natural-looking and long-lasting result. It is delivered in sterile syringes, preloaded and ready for clinical use, and includes two needles.

HYAFILIA® GRAND PLUS is administered via deep intradermal or subcutaneous injection by trained professionals. Its high particle size enables structural correction and deep tissue augmentation.

• Particle size: ~1,100 µm
  
• Injection depth: Deep dermis or subcutaneous tissue
  
• Needle gauge: 23G or 27G (depending on the version)
  
• Packaging: 1ml, 2ml, or 3ml syringes with 2 needles included
  
• Shelf life: 36 months from manufacturing date
  
• Storage: Room temperature (1–30°C), away from direct light

HYAFILIA® GRAND PLUS is indicated for patients seeking temporary correction of deep facial wrinkles, volume enhancement, and facial contouring.

Indications:

• Nasolabial folds
  
• Jawline contouring
  
• Chin augmentation
  
• Cheek volume restoration
  

Contraindications:

• Hypersensitivity to HA or lidocaine
  
• Active skin infections or inflammation at the injection site
  
• Pregnancy or breastfeeding
  
• Autoimmune conditions or bleeding disorders
  

Side Effects:

• Mild swelling or redness at the injection site
  
• Possible bruising or discomfort
  
• Rare hypersensitivity reactions

The formulation includes cross-linked hyaluronic acid stabilized with BDDE to enhance structural integrity and duration.

• Hyaluronic acid concentration: 20 mg/ml
  
• Cross-linking agent: 1,4-Butanediol diglycidyl ether (BDDE)
  
• Appearance: Transparent, viscoelastic gel
  
• Lidocaine: Present for improved patient comfort during injection

Each product unit is individually packed in a sterile format to ensure clinical safety.

• Pre-filled syringe (1 ml, 2 ml, or 3 ml)
  
• Two sterile needles (23G or 27G depending on format)
  
• Instructions for use
  
• Tamper-evident packaging

Yes, like all injectable fillers, HYAFILIA® GRAND PLUS may cause temporary or mild adverse effects.

• Common side effects:
  
  • Swelling
    
  • Redness
    
  • Bruising
    
  • Mild pain at the injection site
    
• Less common side effects:
  
  • Hypersensitivity
    
  • Nodule formation
    
  • Infection (rare)

Proper storage ensures product safety and efficacy.

• Temperature: Store at room temperature (1°C to 30°C)
  
• Light: Keep away from direct sunlight
  
• Shelf life: Up to 36 months from manufacturing date
  
• Do not freeze or use after expiration date