NABOTA® (JEUVEAU®) 200u

NABOTA® (JEUVEAU®) 200u, also known as prabotulinumtoxinA-xvfs, is a botulinum toxin type A product used for temporary aesthetic treatment of moderate to severe glabellar lines (frown lines between the eyebrows) in adults. It acts by blocking the release of acetylcholine at neuromuscular junctions, thereby temporarily paralyzing the target muscles responsible for dynamic wrinkles.

Manufactured with a proprietary purification process, it is designed for precision, purity, and clinical performance comparable to other market-leading neurotoxins. The 200 Unit vial format offers greater flexibility for multi-site treatments, repeated sessions, or high-demand practices.

NABOTA® 200u must be reconstituted and injected intramuscularly by a licensed medical professional familiar with facial anatomy.

Key features:

• Standard treatment for glabellar lines uses 20 Units divided into five sites
  
• Larger vial format allows use across multiple areas or multiple patients (when allowed)
  

Administration guidelines:

• Reconstitute with 2.5 mL of preservative-free 0.9% NaCl for 4 Units per 0.1 mL
  
• Inject 0.1 mL (4 Units) into each of:
  
  • 2 corrugator supercilii (inferomedial and superior middle, both sides)
    
  • 1 midline procerus muscle
    
• Total: 20 Units per session for glabellar lines
  
• Maximum use: no more than every 3 months
  
• Use reconstituted solution within 24 hours, store at 2–8°C, and do not freeze

Indications:

• Temporary aesthetic improvement of moderate to severe glabellar lines in adults
  

Contraindications:

• Known hypersensitivity to botulinum toxin or excipients
  
• Presence of infection at the intended injection site
  

Potential side effects:

• Very common: Headache (12%)
  
• Common: Eyelid ptosis (2%), upper respiratory tract infection (3%)
  
• Rare: Dysphagia, muscle weakness, systemic toxin spread, cardiovascular events

Each 200 Unit vial contains:

• PrabotulinumtoxinA-xvfs (botulinum toxin type A) – 200 Units
  
• Human serum albumin – 1.0 mg
  
• Sodium chloride – 1.8 mg
  

Supplied as a vacuum-dried, preservative-free powder for intramuscular injection after reconstitution.

Each package includes:

• 1 sterile single-dose vial containing 200 Units of vacuum-dried powder
  
• Intended for professional reconstitution and injection
• Packaged in a light-protective sealed carton with complete prescribing information

Yes, NABOTA® 200u may cause local and systemic side effects, particularly when dosing is excessive or injection is improperly administered.

Common adverse effects:

• Headache (up to 12%)
  
• Eyelid drooping or ptosis
  
• Upper respiratory infections
  
• Localized pain, redness, bruising
  

Serious but rare risks:

• Generalized muscle weakness
  
• Respiratory compromise
  
• Dysphagia
  
• Allergic or anaphylactic reactions

Proper storage is essential to preserve safety and potency.

Storage guidelines:

• Store unopened vials at 2°C to 8°C (36°F to 46°F) in original packaging
  
• After reconstitution, use within 24 hours
  
• Do not freeze after dilution
  
• Keep vials protected from light