NUCLEOFILL™ SOFT PLUS

NUCLEOFILL™ SOFT PLUS is a high-purity 0.75% polynucleotide gel specifically formulated for delicate and sensitive areas, particularly the periocular region. It offers a targeted solution for under-eye hollows, fine wrinkles, and dark circles, working by deeply hydrating the tissue, improving microcirculation, and reducing puffiness and pigmentation.

This advanced biorestructuring product has a molecular weight of 1,200 kDa, enabling effective fibroblast stimulation and dermal regeneration in thin, fragile skin. It is particularly recommended for patients showing early signs of aging in the infraorbital zone or for those undergoing aesthetic procedures focused on eye rejuvenation.

The product is administered via microinjection into the superficial to mid dermis of the periocular area.

Key features:

• Designed for eye contour biorevitalization
• Highly tolerable in thin skin zones

Administration guidelines:

• Use 30G needle (12 mm), included
• Inject 0.1 mL per point, spacing points ~1 cm apart
• Recommended technique: multi-point periocular microinjection
• Protocol:
  • 3 sessions: Days 0, 15, and 30
  • Maintenance every 4–6 months

Indications:

• Periocular wrinkles and dark circles
• Dehydration, skin laxity, or under-eye hollows
• Loss of dermal thickness in thin or photodamaged skin
• Pre-treatment priming before surgery or lasers

Contraindications:

• Allergy to polynucleotides
• Pregnancy or breastfeeding
• Autoimmune conditions
• Local infection, skin disease, or inflammation

Side effects may include:

• Mild redness, edema, or bruising
• Tightness or itching
• Rare: nodules, hypersensitivity, or vascular events

Each pre-filled syringe contains:

• 0.75% polynucleotide gel
• Molecular weight: 1,200 kDa
• pH: 6.8–7.2
• Viscosity: 15–20 Pa·s

Derived from purified, natural-origin DNA fragments with no allergenic proteins or additives.

Each box contains:

• 1 × 1.5 mL pre-filled syringe
• 2 × 30G 12 mm needles
• Sterile packaging and usage instructions

Adverse effects are rare and generally limited to mild, local reactions typical of injectable procedures.

Typical side effects:

• Pain, redness, or bruising at injection sites
• Swelling or discomfort lasting up to 48 hours

Uncommon or rare risks:

• Allergic reaction
• Injection site nodules
• Delayed inflammatory responses

Storage instructions:

• Keep at 2°C to 25°C
• Do not freeze
• Store away from light and heat
• Use immediately after opening
• Discard any unused product