NUCLEOFILL™ STRONG

NUCLEOFILL™ STRONG is a 2.5% polynucleotide gel engineered for deep dermal biorestructuring in cases of visible skin aging, pronounced laxity, and marked loss of elasticity and volume. With a molecular weight of 2,500 kDa and high viscosity, it targets not only the dermis but also adipose and osseous tissue, making it one of the most intensive regenerative treatments within the Nucleofill range.

This product is particularly recommended for patients with deep wrinkles, sagging skin, or atrophic areas, offering a long-lasting lifting effect, enhanced hydration, and collagen stimulation. It supports the recovery of dermal architecture and is suitable for face, neck, and body treatments requiring maximum biostimulation.

NUCLEOFILL™ STRONG is injected deeply using linear threading or multipoint techniques.

Key features:

• High-viscosity formulation for deep stimulation
• Indicated for intensive rejuvenation

Protocol guidelines:

• Needle: 30G 12 mm, included
• Dosage: 0.1 mL per point, spacing ~1 cm
• Injection depth: deep dermis, adipose layer, or even subperiosteal depending on indication
• Recommended schedule:
  • Day 0, 15, 30, and 45
  • Maintenance every 6 months

Indications:

• Severe skin aging and laxity
• Deep wrinkles and dermal hypotrophy
• Volume loss in cheeks, jawline, and neck
• Scarred or stressed skin
• Pre- and post-surgical support

Contraindications:

• Allergy to polynucleotides
• Pregnancy or breastfeeding
• Autoimmune or collagen disorders
• Active skin infections
• Recent deep peel or laser procedure

Potential side effects:

• Mild pain, redness, or bruising
• Localized swelling
• Rare: nodules, inflammatory reaction, or vascular complications

Each syringe contains:

• 2.5% polynucleotide gel
• Molecular weight: 2,500 kDa
• pH: 6.8–7.5
• Viscosity: 48–65 Pa·s

Polynucleotides are highly purified and derived from natural sources, without allergenic proteins.

Each box includes:

• 1 × 1.5 mL pre-filled syringe
• 2 × 30G 12 mm needles
• Sterile packaging and instructions for use

Yes, but they are usually mild and short-lived, typical of injectable procedures.

Common side effects:

• Redness, bruising, or pain at injection site
• Edema or tightness

Rare side effects:

• Nodules, delayed hypersensitivity, or vascular events

Storage instructions:

• Store at 2°C to 25°C
• Keep in original box, away from light and heat
• Do not freeze
• Use immediately after opening
• Dispose of any unused portion