PROFHILO® STRUCTURA

PROFHILO® STRUCTURA is a next-generation injectable bioremodeling treatment designed to restore facial fat volume and improve midface contour. Unlike conventional dermal fillers, it acts on superficial facial fat compartments, supporting adipose tissue regeneration for a naturally rejuvenated appearance.

This product contains 90 mg of ultrapure hyaluronic acid formulated with NAHYCO® hybrid cooperative complexes (HCCs), offering high biocompatibility without chemical cross-linking agents. PROFHILO® STRUCTURA is particularly suitable for patients with midface volume loss, including those affected by age-related fat depletion or rapid weight loss due to GLP-1 therapy.

The product is injected into the superficial fat compartments of the midface using a blunt-tip cannula technique to improve safety and precision. The treatment involves two sessions, spaced one month apart, using one syringe (2 mL) per session.

• Injection site: Midface preauricular region

• Injection depth: Superficial fat layer

• Device: 25G x 38 mm or 22G x 50 mm cannula

• Volume per session: 2 mL (entire syringe)

• Frequency: 2 treatments, spaced 30 days apart

• No massage or manipulation needed post-injection

• Results observed at 1 and 3 months post-treatment

PROFHILO® STRUCTURA is indicated for the restoration and remodeling of superficial facial fat in patients experiencing midface volume loss, flattening, or sagging. It is a regenerative alternative for patients seeking natural results without conventional filler volume.

Indications:

• Midface hollows and structural flattening

• Sagging cheeks and reduced facial projection

• Age-related facial fat loss

• Weight-loss-associated facial volume reduction (e.g., post-Ozempic)

Contraindications:

• Pregnancy or breastfeeding

• Hypersensitivity to hyaluronic acid

• Active skin infections or inflammatory conditions at the injection site

Side Effects:

• Mild redness, swelling, or bruising

• Very low incidence of adverse events with cannula technique

• No BDDE means reduced risk of inflammatory reactions

• 77.1% fewer vascular complications when using cannulas

The product is composed of ultrapure hyaluronic acid combined using NAHYCO® hybrid cooperative complex technology, without the use of chemical cross-linking agents. This enables deep tissue bio-integration and long-lasting efficacy.

• Hyaluronic acid (HA): 90 mg per 2 mL

  • 45 mg low molecular weight HA (80–100 kDa)

  • 45 mg high molecular weight HA (1100–1400 kDa)

• No BDDE or other cross-linking chemicals

• pH-neutral, biocompatible formula

Each package contains all the necessary components for safe and effective treatment, including prefilled syringes and sterile accessories.

• 1 pre-filled syringe containing 2 mL of PROFHILO® STRUCTURA

• 2 cannulas:

  • 1 x 22G x 50 mm

  • 1 x 25G x 38 mm

• 2 pilot needles for cannula insertion:

  • 1 x 21G x 25 mm

  • 1 x 23G x 19 mm

• Instructions for use, patient card, and traceability label

Side effects with PROFHILO® STRUCTURA are generally minimal and self-limiting. The product’s high purity and cannula-based delivery significantly reduce the risk of complications.

• Mild and temporary reactions such as swelling, redness, or bruising

• Low risk of vascular occlusion with cannula injection (77.1% reduction)

• No known delayed hypersensitivity due to absence of BDDE

• No massage required post-treatment reduces trauma

Proper storage is essential to maintain the integrity of the product. PROFHILO® STRUCTURA must be kept within a specific temperature range and protected from light.

• Store at 2°C to 25°C

• Keep out of direct sunlight

• Do not freeze

• Use before the expiry date listed on the packaging