STYLAGE® L BI-FLEX® with Lidocaine

Product Specifications

• Active Ingredients: Cross-linked hyaluronic acid 24mg/g; mannitol 9mg/mL; lidocaine 3mg/mL
• Strength: 24mg/g HA | 9mg/mL mannitol | 3mg/mL lidocaine
• Dosage Form: Injectable gel
• Format: 2 × 1mL prefilled syringes + 4 × 30G ½ needles
• Manufacturer: Laboratories VIVACY
• Brand: STYLAGE®
• Country of Origin: France
• Drug Class: Cross-linked injectable hyaluronic acid dermal filler
• Regulatory Status: CE-marked for EU use; verify current FDA and local jurisdiction status before use
• Route of Administration: Intradermal, subdermal, or subcutaneous injection, depending on treatment area and clinical objective
• Storage Requirements: Store below 25°C; do not freeze; protect from direct sunlight
• Intended Use: Licensed aesthetic medicine professionals only

What is STYLAGE® L BI-FLEX® with Lidocaine?

STYLAGE® L BI-FLEX® with Lidocaine is a cross-linked hyaluronic acid dermal filler manufactured by Laboratories VIVACY in France and used in aesthetic medicine for deep wrinkle correction, facial volume restoration, and contour refinement in licensed clinical settings. It uses IPN-Like Technology™ (Interpenetrating Network technology) with interlocked hyaluronic acid polymer networks designed to support elasticity, cohesivity, and controlled gel behavior. The BI-FLEX® designation refers to its optimized rheological profile, which is intended to enable smooth injection and tissue integration. Product selection should be based on the treatment area, degree of correction required, condition of the patient's skin, injector technique, and individual risk assessment. The STYLAGE® range is CE-marked for EU use; practitioners asking whether STYLAGE® is FDA approved should verify current US FDA status, as approval is product- and indication-specific.

How Does STYLAGE® L BI-FLEX® with Lidocaine Work?

STYLAGE® L BI-FLEX® with Lidocaine works through the physicochemical properties of cross-linked hyaluronic acid. The HA gel binds water molecules at the injection site, creating an immediate volumizing and hydrating effect that helps smooth deeper folds and restore soft tissue support. IPN-Like Technology™ uses interlocked polymer networks designed to support gel cohesivity, elasticity, and resistance to deformation. Mannitol acts as an antioxidant and free radical scavenger that may help limit oxidative degradation of the HA matrix, which may contribute to product longevity. Lidocaine 3mg/mL is co-formulated as a local anesthetic to reduce discomfort during injection. Like other HA-based fillers, the gel is gradually degraded by endogenous hyaluronidase and may be reversed with hyaluronidase injection when clinically appropriate.

What Are the Administration & Injection Guidelines for STYLAGE® L BI-FLEX®?

• Pre-treatment assessment: Evaluate medical history, allergies, prior filler use, active infection, inflammation, pregnancy/lactation status, anticoagulant use, autoimmune history, and risk factors for vascular compromise.
• Aseptic technique: Use sterile technique, appropriate skin preparation, and careful selection of the injection plane.
• Injection technique: Linear threading, fanning, or cross-hatching may be used based on clinical preference and treatment area.
• Lidocaine: Co-formulated at 3mg/mL; additional topical anesthesia may be used based on clinical preference and patient sensitivity.
• Post-treatment care: Advise patients to avoid sun exposure, UV light, extreme heat, alcohol, and strenuous activity until redness or swelling resolves.
• Expected local reactions: Bruising at the injection site, redness, swelling, tenderness, and mild discomfort may occur and typically resolve within a few days.
• Follow-up: Touch-up sessions should be based on practitioner assessment rather than a fixed schedule.
• Reversal: HA filler may be dissolved with hyaluronidase when clinically indicated.
• Storage: Store below 25°C, protect from direct sunlight, and do not freeze.

Longevity of STYLAGE® filler is commonly described as approximately 12–18 months, but the duration varies by treatment area, injection technique, tissue mobility, HA metabolism, lifestyle, skin type, and condition of the patient's skin. Duration should be communicated as an expected range rather than a guaranteed outcome.

What Are STYLAGE® L BI-FLEX® with Lidocaine’s Indications?

Trained aesthetic professionals use STYLAGE® L BI-FLEX® with Lidocaine for correction objectives that require structural support, wrinkle filling, and volume restoration. Intended or commonly referenced uses include:

• Deep wrinkle correction: Including nasolabial folds, marionette lines, and glabellar lines, depending on local labeling and clinical judgment.
• Moderate to severe facial folds: Including deeper facial lines that require mid-to-deep dermal or subdermal correction.
• Volume restoration: For facial regions affected by age-related volume loss, at the medium-to-deep dermis or subcutaneous plane.
• Facial contouring: Including cheeks, chin, and jawline, where appropriate to anatomy, injection plane, and clinical assessment.
• Perioral and lower-face support: Depending on the treatment area, tissue quality, and correction objective.

Treatment area selection should consider the degree of volume loss, condition of the patient's skin, tissue thickness, vascular anatomy, injection plane, and factors such as skin type, age, lifestyle, and prior aesthetic treatments. Other STYLAGE® formulations have different indications and should be treated as separate products.

What Are the Side Effects & Safety Considerations?

Common side effects are generally localized and transient. They may include bruising at the injection site, redness, swelling, tenderness, pain, itching, firmness, discoloration, or mild nodularity. These reactions often resolve within a few days, but persistence, worsening pain, blanching, livedo, or visual symptoms require urgent clinical evaluation. Rare but serious risks include vascular occlusion, skin necrosis, visual disturbance or vision loss, infection or abscess formation, granuloma or delayed inflammatory reaction, hypersensitivity reaction, and lidocaine-related systemic reactions in sensitive patients. Before treatment, practitioners should review allergies, medications, anticoagulant use, autoimmune history, prior filler complications, and lidocaine sensitivity. Bleeding risk may increase in patients using anticoagulants, antiplatelet agents, NSAIDs, or supplements that affect coagulation. Refer to the product IFU and local clinical protocols for complete information on contraindications, adverse events, and management.

Legal Status of STYLAGE® L BI-FLEX® with Lidocaine

Current as of May 2026, STYLAGE® L BI-FLEX® with Lidocaine is manufactured in France by Laboratories VIVACY and belongs to the CE-marked STYLAGE® range for professional aesthetic use in relevant European markets. Use remains subject to local regulatory requirements, professional scope of practice, and product-specific labeling. Regarding US regulatory status: FDA approval for dermal fillers is product- and indication-specific. STYLAGE® L BI-FLEX® with Lidocaine should not be represented as FDA-approved unless confirmed through current FDA databases or official labeling. Practitioners should verify local regulatory status, formulary eligibility, and professional-use requirements before procuring, discussing, or administering the product.

Availability and Access to STYLAGE® L BI-FLEX® with Lidocaine

Access to STYLAGE® L BI-FLEX® with Lidocaine should be limited to licensed healthcare professionals, registered aesthetic clinics, and qualified injectors working within applicable regulatory requirements. Product evaluation should include verification of professional eligibility, product documentation, handling conditions, expiry information, and jurisdiction-specific restrictions before use in aesthetic medicine. Professionals evaluating how to buy STYLAGE® L BI-FLEX® wholesale should avoid treating product availability as equivalent to authorization for use in a specific market. When buying online, authenticity checks should include batch documentation, packaging integrity, storage conditions, and confirmation that the product is being used only in licensed clinical settings. Practitioners who wish to buy dermal fillers or buy STYLAGE® may contact Doctor Medica's staff for guidance on finding qualified suppliers and documentation support.