STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine

Product Specifications

• Active Ingredients: Cross-linked hyaluronic acid 20mg/mL; lidocaine 0.3%
• Strength: 20mg/mL HA | 0.3% lidocaine
• Dosage Form: Injectable gel
• Format: 1 × 1mL prefilled syringe + 2 × 30G ½ needles
• Manufacturer: Laboratories VIVACY
• Brand: STYLAGE®
• Country of Origin: France
• Drug Class: Cross-linked injectable hyaluronic acid filler for lip augmentation, with lidocaine
• FDA Approval Date: Not confirmed; verify current US FDA status before use
• Regulatory Status: CE-marked for EU use; verify current FDA and local jurisdiction status before use
• Route of Administration: Intradermal, subdermal, or submucosal injection, depending on the lip treatment area and correction objective
• Storage Requirements: Store below 25°C; do not freeze; protect from direct sunlight
• Intended Use: Licensed aesthetic medicine professionals only

What is STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine?

STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine is a cross-linked hyaluronic acid filler engineered by Laboratories VIVACY (France) specifically for lip enhancement and perioral rejuvenation. Key architectural components include:

• Advanced Formulation: Features a 20mg/g HA concentration, which is denser than the standard 18.5mg/g STYLAGE® Lips formula, to deliver more pronounced volume, crisp border definition, and structural correction.
• IPN-Like Technology™: Utilizes an interpenetrating polymer network that enhances gel cohesivity and elasticity, allowing the filler to withstand constant mechanical movement from expressions, speech, and eating.
• Bi-FLEX® Syringe System: Administered via VIVACY's next-generation ergonomic delivery hardware, optimizing injection force and stability for precision placement in sensitive tissues.
• Patient Comfort: Co-formulated with 0.3% lidocaine to minimize procedural discomfort.

Regulatory Note: The STYLAGE® portfolio is CE-marked for distribution in Europe. Because regulatory approvals for dermal fillers are product- and territory-specific, practitioners should independently verify current US FDA status prior to procurement.

How Does STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine Work?

STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine works through cross-linked hyaluronic acid, which binds water within lip tissue to create immediate volume, hydration, and soft tissue support at the injection site. IPN-Like Technology™ uses interlocked HA polymer networks designed to resist deformation under mechanical pressure, which is relevant to the lips, given their frequent movement during speech, eating, and facial expressions. BI-FLEX® rheology supports cohesive but flexible gel behavior that adapts to lip tissue dynamics. Lidocaine 0.3% is an amide-type local anesthetic co-formulated within the gel to reduce discomfort during injection in the lip treatment area. Like other HA-based injectable dermal fillers, the product is gradually degraded by endogenous hyaluronidase and may be reversed with hyaluronidase injection when clinically appropriate.

What Is STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine Used For?

STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine is used in professional aesthetic settings where lip volume, lip contour, or perioral support is required. Product selection should consider lip anatomy, degree of volume loss, treatment area, tissue mobility, patient goals, and local product labeling.

• Lip augmentation: Used to enhance lip body volume and fullness.
• Lip border definition: Used for vermillion border refinement and improved lip contour.
• Perioral volume restoration: Used to support tissues around the mouth affected by age-related volume loss.
• Perioral line correction: May be used around the lips, depending on the treatment area, injection depth, and product labeling.
• Philtrum and Cupid's bow definition: Used where appropriate to support lip architecture and shape.
• Professional aesthetic procedures: Intended for trained aesthetic professionals familiar with injectable dermal fillers and lip-related vascular anatomy.

How Is STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine Injection Administered?

STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine injection is administered in the lip body, vermillion border, philtrum columns, Cupid's bow, or perioral treatment area, depending on the clinical objective. Injection depth and technique should be selected based on lip anatomy, tissue quality, degree of volume loss, and the desired level of augmentation. Technique options may include

• Linear threading
• Serial puncture
• Microbolus placement
• Fanning

Choosing the right technique depends on practitioner preference and local labeling. Volume per session is at the practitioner's discretion; overcorrection should be avoided, given the vascularity, mobility, and swelling tendency of lip tissue.

• Pre-treatment assessment: Evaluate medical history, allergies, prior filler use, active infection, inflammation, history of cold sores, pregnancy/lactation status, anticoagulant use, autoimmune history, and risk factors for vascular compromise.
• Aseptic technique: Use sterile technique and select the appropriate injection plane.
• Lidocaine: Co-formulated at 0.3%; screen for hypersensitivity to amide-type local anesthetics. Additional topical anesthesia may be used at the practitioner's discretion.
• Post-treatment care: Advise patients to avoid sun exposure, UV light, extreme heat, alcohol, and strenuous activity until redness or swelling resolves.
• Expected local reactions: Swelling, bruising at the injection site, redness, tenderness, and mild discomfort may occur and typically resolve within a few days.
• Follow-up: Touch-up or follow-up sessions should be determined by practitioner assessment and lip symmetry evaluation.
• Reversal: HA filler may be dissolved with hyaluronidase when clinically indicated.
• Storage: Store below 25°C, protect from direct sunlight, and do not freeze.

What Are the Side Effects and Safety Considerations?

The most clinically significant risk is inadvertent intravascular injection leading to vascular occlusion. Because the perioral region is highly vascular, immediate recognition and access to a reversal protocol (hyaluronidase) are mandatory.

Common & Transient Reactions (Resolve in a few days)

• Injection Site Issues: Localized swelling, bruising, redness, tenderness, pain, or mild itching.
• Tissue Response: Temporary firmness or mild nodularity.
• Note: Due to the vascularity and mobility of lip tissue, post-procedure swelling is typically more pronounced than in other facial zones.

Rare but Serious Risks (Require urgent clinical evaluation)

• Ischemic/Vascular: Vascular occlusion, skin necrosis, or visual disturbance/vision loss.
• Immune/Infectious: Infection/abscess formation, hypersensitivity, or granulomas (delayed inflammatory reactions).
• Systemic: Lidocaine-related systemic reactions in sensitive individuals.

Pre-Treatment Screening Checklist

Before administration, practitioners must screen patients for:

• Medical History: Active infections, autoimmune history, history of cold sores, and prior filler complications.
• Allergies: Known sensitivities to hyaluronic acid or amide-type local anesthetics (lidocaine).
• Medications: Use of anticoagulants, antiplatelet agents, NSAIDs, or supplements that may elevate bleeding and bruising risks.

What Is the Legal Status of STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine?

Current as of May 2026, STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine is manufactured in France by Laboratories VIVACY and belongs to the STYLAGE® range, which is CE-marked for professional aesthetic use in Europe. The product should be used only by licensed aesthetic medicine professionals, dermatologists, plastic surgeons, or registered aesthetic clinics operating in accordance with local regulatory requirements. Current US FDA status should be verified before procurement or use. FDA approval for dermal fillers is product- and indication-specific, and STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine should not be represented as FDA-approved unless confirmed in current FDA databases or official labeling. Practitioners should also verify importation rules, professional-use restrictions, and local requirements before any patient-facing discussion or administration.

Availability and Access to STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine

Access to STYLAGE® LIPS PLUS BI-FLEX® with Lidocaine should be restricted to licensed healthcare professionals, registered aesthetic clinics, and qualified injectors operating within local regulatory requirements. Product evaluation should include a review of professional eligibility, batch documentation, packaging integrity, expiry information, storage requirements, and jurisdiction-specific restrictions. Professionals evaluating how to buy STYLAGE® LIPS PLUS BI-FLEX® wholesale should not treat product availability as equivalent to clinical authorization in a specific market. When buying online, practitioners should verify authenticity documentation, product traceability, storage conditions, and whether the product is appropriate for professional aesthetic medicine use. Practitioners who wish to buy dermal fillers or buy STYLAGE® products may contact Doctor Medica's staff for information and documentation support.