STYLAGE® S BI-FLEX® with Lidocaine

Product Specifications

• Active Ingredients: Cross-linked hyaluronic acid 16mg/g; mannitol 9mg/mL; lidocaine 3mg/mL
• Strength: 16mg/g HA | 9mg/mL mannitol | 3mg/mL lidocaine
• Dosage Form: Injectable gel
• Format: 2 × 0.8mL prefilled syringes (BI-FLEX® syringe system, rebranded from Bi-SOFT®) + 4 × 30G ½ needles
• Manufacturer: Laboratories VIVACY
• Brand: STYLAGE®
• Country of Origin: France
• Drug Class: Cross-linked injectable hyaluronic acid dermal filler, superficial plane, with mannitol and lidocaine
• FDA Approval Date: Not confirmed; verify current US FDA status before use
• Regulatory Status: CE-marked for EU use; verify current FDA and local jurisdiction status before use
• Route of Administration: Intradermal injection into the superficial dermis
• Storage Requirements: Store below 25°C; do not freeze; protect from direct sunlight
• Intended Use: Licensed aesthetic medicine professionals only

What Is STYLAGE® S BI-FLEX® with Lidocaine?

Within the STYLAGE® range, this formulation occupies the superficial end of the correction spectrum. At 16mg/g HA, its concentration is lower than STYLAGE® M and STYLAGE® L, making it suited to fine line correction and surface wrinkle treatment rather than deep volumization or structural support. It is manufactured by Laboratories VIVACY in France and CE-marked for professional aesthetic use in the EU. The product uses IPN-Like Technology™ — Interpenetrating Network technology — in which interlocked HA polymer networks support elasticity, cohesivity, and resistance to deformation in high-movement, superficial-plane treatment areas. Mannitol 9mg/mL acts as an antioxidant and free-radical scavenger that may help limit oxidative degradation of HA, thereby contributing to product longevity. Lidocaine 3mg/mL is co-formulated to reduce discomfort during injection, which is particularly relevant in sensitive periorbital and perioral treatment areas. The BI-FLEX® syringe system is the rebranded successor to Bi-SOFT®, updated to offer improved ergonomics, enhanced injection precision, and greater safety. The current version is identified by its soft purple-and-white packaging. Practitioners asking whether STYLAGE® is FDA-approved should independently verify its current US FDA status, as regulatory authorization is product- and indication-specific. Since the STYLAGE® dermal filler has CE-marked status, IPN-Like Technology™, mannitol-supported longevity, and a refined delivery system, its suitability for a given patient should be determined by clinical assessment of treatment area, skin condition, and correction objective.

How Does STYLAGE® S BI-FLEX® with Lidocaine Work?

In the superficial dermis, where tissue movement is constant and placement precision is critical, the structural behavior of the injected gel matters as much as its volumizing effect. STYLAGE® S BI-FLEX® with Lidocaine delivers cross-linked HA that binds water at the injection site, producing an immediate smoothing and hydrating effect. IPN-Like Technology™ supports cohesivity and resistance to deformation, helping the gel maintain structural integrity under the mechanical demands of superficial tissue. Mannitol 9mg/mL scavenges free radicals that would otherwise accelerate enzymatic HA breakdown, potentially extending product longevity. How long STYLAGE® filler lasts depends on factors such as skin type, treatment area, injection technique, lifestyle, and condition of the patient's skin. Duration should be discussed with patients as an expected range rather than a fixed outcome. Like all HA fillers, this product is gradually degraded by endogenous hyaluronidase and is reversible with hyaluronidase injection when clinically required.

What Is STYLAGE® S BI-FLEX® with Lidocaine Used For?

STYLAGE® S BI-FLEX® with Lidocaine is suited to cases where correction is needed at the surface level. It can serve as a standalone treatment for fine lines or as part of a layered approach alongside deeper STYLAGE® formulations.

• Fine line correction: Superficial facial lines where deep volumization is not required.
• Superficial wrinkle treatment: Surface-level lines in the superficial dermis, including periorbital and perioral lines.
• Skin texture refinement: Superficial correction and hydration support where clinically appropriate.
• Nasolabial folds and marionette lines: Superficial component correction only — not indicated for deeper volume correction in these areas.
• Professional aesthetic procedures: For trained professionals familiar with injectable dermal fillers, superficial injection technique, and complication management.

Treatment area selection should consider skin quality, patient skin condition, injection plane, and factors such as skin type, age, and lifestyle. STYLAGE® S BI-FLEX® with Lidocaine is not intended for deep volumization.

How Is STYLAGE® S BI-FLEX® with Lidocaine Injection Administered?

STYLAGE® S BI-FLEX® with Lidocaine injection is placed in the superficial dermis using an intradermal technique. The BI-FLEX® syringe system supports improved precision for superficial-plane injection compared to the former Bi-SOFT® design. Technique options include linear threading, serial puncture, or microdepot placement; volume per session is at the practitioner's discretion, with care taken to avoid overcorrection given the visibility of superficial irregularities.

• Pre-treatment assessment: Review allergies, prior filler use, active infection, inflammation, pregnancy/lactation status, anticoagulant use, autoimmune history, and vascular risk factors.
• Aseptic technique: Use sterile technique and select the appropriate injection plane.
• Lidocaine: Co-formulated at 3mg/mL; screen for hypersensitivity to amide-type local anesthetics.
• Post-treatment care: Advise patients to avoid sun exposure, UV light, extreme heat, alcohol, and strenuous activity until redness or swelling resolves.
• Expected local reactions: Swelling, bruising at the injection site, redness, tenderness, and mild discomfort may occur and typically resolve within a few days.
• Reversal: HA filler may be dissolved with hyaluronidase when clinically indicated.
• Storage: Store below 25°C, protect from direct sunlight, and do not freeze.

What Are the Side Effects and Safety Considerations?

The most clinically significant safety concern with HA fillers is inadvertent intravascular injection and vascular occlusion. Common side effects are usually localized and transient, including swelling, redness, tenderness, bruising, pain, itching, firmness, discoloration, or mild nodularity. Persistence, worsening pain, blanching, livedo, or visual symptoms require urgent evaluation. Serious but rare risks include vascular occlusion, skin necrosis, visual disturbance or vision loss, infection or abscess formation, granuloma, delayed inflammatory reaction, hypersensitivity, persistent nodules, and lidocaine-related systemic reactions in sensitive patients. Practitioners should review the product IFU and local clinical protocols for complete contraindication, adverse event, and management information before use.

Legal Status of STYLAGE® S BI-FLEX® with Lidocaine

Current as of May 2026, STYLAGE® S BI-FLEX® with Lidocaine is manufactured in France by Laboratories VIVACY and is CE-marked for professional aesthetic use in the EU. Use remains subject to local regulatory requirements, professional scope of practice, and product-specific labeling. Current US FDA status is not confirmed; practitioners should verify FDA approval, importation rules, local registration requirements, and scope-of-practice restrictions before procurement or use. STYLAGE® S BI-FLEX® with Lidocaine should not be represented as FDA-approved unless confirmed through current FDA databases or official labeling.

Availability & Access to STYLAGE® S BI-FLEX® with Lidocaine

Access to STYLAGE® S BI-FLEX® with Lidocaine should be limited to licensed healthcare professionals, registered aesthetic clinics, and qualified injectors operating within local regulatory requirements. Practitioners evaluating how to buy STYLAGE® S BI-FLEX® wholesale should review supplier qualification, authenticity documentation, storage conditions, lot number traceability, and regulatory status before procurement. When buying online, product documentation and handling standards should be verified before any order is placed. Practitioners who wish to buy dermal fillers or buy STYLAGE® products may contact Doctor Medica's staff for sourcing information and documentation support.