NABOTA® (JEUVEAU®) 100u

NABOTA® (JEUVEAU®) 100u, also known as prabotulinumtoxinA-xvfs, is a purified botulinum toxin type A injectable neurotoxin used for temporary improvement of moderate to severe glabellar lines (frown lines between the eyebrows) in adults. It works by inhibiting acetylcholine release at neuromuscular junctions, resulting in targeted muscle relaxation.

Manufactured using a proprietary purification process, NABOTA®/Jeuveau® offers high clinical efficacy with a safety profile similar to other botulinum toxins. Each vial contains 100 Units of vacuum-dried powder, to be reconstituted before use.

NABOTA® is intended for intramuscular injection by a licensed medical professional. Proper dilution and anatomical knowledge are critical for safe and effective treatment.

Key features:

• Administered at five injection sites in the glabellar complex
  
• Standard dose: 20 Units total (4 Units per site)
  

Injection protocol:

• Reconstitute 100 Units with 2.5 mL preservative-free 0.9% NaCl (yields 4 Units per 0.1 mL)
  
• Inject 0.1 mL (4 Units) at each of:
  
  • Inferomedial corrugator (left and right)
    
  • Superior corrugator (left and right)
    
  • Midline of procerus
    
• Avoid injections <1 cm above central eyebrow to minimize ptosis risk
  
• Use within 24 hours post-reconstitution; refrigerate at 2–8°C

Indications:

• Temporary improvement of moderate to severe glabellar lines in adults
  

Contraindications:

• Hypersensitivity to any botulinum toxin product
  
• Infection at proposed injection site(s)
  

Potential side effects:

• Very common: Headache (12%)
  
• Common: Eyelid ptosis (2%), upper respiratory tract infection (3%)
  
• Other: Injection site pain, local weakness, eyelid swelling, allergic reactions
  

Serious adverse events may include dysphagia, respiratory distress, and systemic toxin spread (rare but potentially life-threatening).

Each 100 Unit vial contains:

• PrabotulinumtoxinA-xvfs (botulinum toxin type A) – 100 Units
  
• Human serum albumin – 0.5 mg
  
• Sodium chloride – 0.9 mg
  

The powder is vacuum-dried, sterile, and preservative-free.

Each package includes:

• 1 single-use vial with 100 Units of vacuum-dried powder
  
• Intended for single reconstitution and patient use
  
• Packaged in a protective carton to avoid light exposure

Yes, like all botulinum toxin products, NABOTA®/Jeuveau® may cause both localized and systemic side effects.

Common side effects:

• Headache (up to 12%)
  
• Eyelid ptosis (2%)
  
• Upper respiratory tract infection (3%)
  
• Injection site pain, bruising, or swelling
  

Rare but serious risks:

• Systemic toxin spread → muscle weakness, respiratory distress, dysphagia
  
• Allergic reactions including anaphylaxis
  
• Arrhythmia, heart attack (rare)

Storage instructions:

• Unopened vials: Store at 2°C to 8°C (36°F to 46°F), in original carton
  
• Reconstituted solution: Store at 2°C to 8°C and use within 24 hours
  
• Do not freeze after reconstitution
  
• Protect from light and contamination