Tesofensine (500mcg) 30 Capsules

What is Tesofensine (500mcg) Capsules x30?

It contains 30 capsules, each formulated with 500 mcg of Tesofensine. Although Tesofensine is frequently grouped with research compounds studied in neuroscience, it is a synthetic small molecule rather than a peptide. Tesofensine has been examined in laboratory and clinical research for its influence on monoamine neurotransmitter signaling, particularly in studies investigating appetite regulation, metabolic activity, and neural pathways related to feeding behavior. Within research categories often referred to as brain, cognitive, and nootropic peptides, Tesofensine is characterized by:

• CAS Number: 195875-84-4
• Chemical Formula: C₁₇H₂₃Cl₂NO
• Molecular Weight: 328.3 g/mol

Because it is not derived from a protein structure, Tesofensine does not have a peptide sequence. Research-grade material is typically produced with high purity and is commonly verified by analytical methods such as HPLC and mass spectrometry, ensuring consistency across experimental environments.

What are the key features of Tesofensine (500mcg) Capsules x30?

• 500 mcg Tesofensine per capsule supplied in a 30-count bottle
• High-purity material typically verified through HPLC analysis
• Compound identity confirmed through mass spectrometry (MS)
• Oral capsule format suitable for pharmacokinetic and pharmacodynamic studies
• Studied in research involving neurotransmitter signaling, appetite regulation, and metabolism
• Stable formulation intended for controlled laboratory investigation
• For laboratory research use only

How is Tesofensine (500mcg) Capsules x30 synthesized?

Tesofensine is produced through synthetic organic chemistry, rather than peptide synthesis. The compound is assembled through multiple reaction steps that build its molecular structure, which includes a dichlorophenyl group and a bicyclic framework associated with monoamine transporter activity. Because Tesofensine is not derived from natural proteins or amino acids, it does not require peptide-based synthesis methods. Following chemical synthesis, the compound is purified using high-performance liquid chromatography (HPLC) to remove residual impurities or intermediate compounds. Analytical verification typically includes mass spectrometry (MS) to confirm the compound’s molecular weight and structural identity. The purified active ingredient is then encapsulated with inert excipients under controlled conditions to produce capsules suitable for research use.

What is Tesofensine (500mcg) Capsules x30 being studied for? What are its possible benefits?

Tesofensine has been studied in both preclinical and clinical research for its potential effects on body-weight regulation, energy balance, and appetite signaling. Several investigations have explored how modulation of monoamine neurotransmitters may influence feeding behavior and metabolic processes in animal models and controlled human studies. Additional research has examined Tesofensine’s potential effects on energy expenditure, fat metabolism, and central nervous system pathways involved in appetite control. Studies have also evaluated its influence on hypothalamic signaling and behavioral responses related to satiety. These biological outcomes remain under scientific investigation and should be interpreted as experimental observations rather than confirmed biological outcomes.

How does Tesofensine (500mcg) Capsules x30 work in research studies?

In laboratory studies, Tesofensine is believed to influence neurotransmitter signaling by limiting the reuptake of dopamine, norepinephrine, and serotonin in the central nervous system. When reuptake is reduced, the concentration of these neurotransmitters may increase within synaptic spaces, thereby altering neuronal communication and behavioral responses associated with appetite and motivation. Researchers use Tesofensine to investigate how changes in monoamine signaling affect neural circuits involved in feeding behavior and metabolic regulation. Experimental models have suggested that increased neurotransmitter activity in certain brain regions may influence satiety signals, energy expenditure, and other physiological processes related to metabolic balance.

What dosing information exists for Tesofensine (500mcg) Capsules x30?

Preclinical dosing in rodent models typically involves subcutaneous administration in the microgram-per-kilogram range, with dose selection depending on species, sampling interval, and study objective. Dose design should be guided by peer-reviewed preclinical protocols. No standardized human dosing guidelines exist for Tesofensine (500mcg) Capsules x30 as a research reagent.

How should Tesofensine (500mcg) Capsules x30 be stored and handled?

• Store in a cool, dry place at controlled room temperature
• Protect from light and moisture to maintain compound stability
• Handle capsules with clean laboratory tools to avoid contamination
• When stored correctly, capsules may maintain stability for up to 24 months

Where can I read more research about Tesofensine (500mcg) Capsules x30?

1. Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology. 2010;35(7):1464-1476. doi:10.1038/npp.2010.16
2. Perez CI, Luis-Islas J, Lopez A, et al. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS One. 2024;19(4):e0300544. Published 2024 Apr 24. doi:10.1371/journal.pone.0300544
3. National Center for Biotechnology Information. PubChem Compound Summary for CID 11370864, Tesofensine. https://pubchem.ncbi.nlm.nih.gov/compound/Tesofensine

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.