Dihexa (8mg) 30 Tablets

What is Dihexa (8mg) x 30 Tablets? Dihexa is a synthetic, small-molecule peptide derivative structurally related to angiotensin IV. It is composed of a modified hexapeptide sequence designed to enhance stability and bioavailability in experimental settings. Dihexa has been characterized in preclinical models as blood-brain barrier-permeable and orally active, making it a subject of investigation in neuropharmacology. It has been studied for its potential effects on synaptic function, neuronal signaling, and growth-factor pathways. Dihexa is under investigation in preclinical models exploring mechanisms relevant to neurobiology and cellular communication.

What are the key features of Dihexa (8mg) x 30 Tablets?

Dihexa (8mg) x 30 Tablets is supplied in a pre-measured tablet format intended for laboratory research applications. Each tablet contains 8 mg of analytically verified peptide material.

Key Features

• CAS Number: 1401708-83-5
• Purity: ≥98% purity confirmed by HPLC
• Chemical Formula: C₂₇H₄₄N₄O₅
• Molecular Weight:7 g/mol
• Sequence: Hexanoyl-Tyr-Ile-Unk (N-Hexanoyl-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
• Identity verification: Verified via mass spectrometry (MS)
• Structure: Synthetic analog of angiotensin IV
• Format: Supplied as 30 tablets (verify exact format with supplier)
• For laboratory research use only
• Supports structured experimental design and preclinical evaluation

How is Dihexa (8mg) x 30 Tablets synthesized?

Dihexa is synthesized via solid-phase peptide synthesis (SPPS), in which protected amino acids are sequentially coupled to form the modified hexapeptide sequence. This synthetic peptide is designed to mimic the activity of angiotensin IV while offering enhanced stability and bioavailability. After synthesis, Dihexa is purified by high-performance liquid chromatography (HPLC) to ensure high purity. Mass spectrometry (MS) and other analytical procedures are used to confirm molecular identity. Stability testing and amino acid analysis may also be performed to verify the product’s quality and reproducibility.

What is Dihexa (8mg) x 30 Tablets being studied for? What are its possible benefits?

Dihexa has been studied primarily in preclinical research related to neuronal function and synaptic connectivity. Research has explored its potential role in cognitive function, synaptogenesis, and cellular communication networks. Research areas include:

• Neuronal growth and synaptic density
• Cognitive and memory-related pathways in animal models
• Growth factor modulation
• Neuroprotective mechanisms

Potential biological effects under investigation include enhanced synaptic signaling and support of cellular communication networks. These findings are based on laboratory and animal studies, and no clinical efficacy has been established.

How does Dihexa (8mg) x 30 Tablets work in research studies?

In research studies, Dihexa is thought to influence growth-related signaling pathways. Preclinical evidence suggests it may interact with hepatocyte growth factor (HGF), which plays a role in cellular growth and structural remodeling in neural tissue. Rather than acting as a traditional receptor agonist, Dihexa is described as enhancing signaling cascades associated with synaptic development. Experimental studies have shown its potential effects on synapse formation and maintenance in cell culture and animal models. These mechanisms are still under investigation and remain to be fully characterized.

What dosing information exists for Dihexa (8mg) x 30 Tablets?

Dosing information for Dihexa is limited to preclinical research models. Published animal studies have administered Dihexa at microgram-per-kilogram doses, including approximately 10 µg/kg in murine models assessing cognitive function and synaptic endpoints. In vitro research has used concentration-dependent exposure in cultured neuronal cells to observe changes in synaptic markers and signaling proteins. No standardized human dosing guidelines exist, as Dihexa has not been approved for clinical use, and all available dosage data are derived from experimental laboratory or animal studies.

How should Dihexa (8mg) x 30 Tablets be stored and handled?

Dihexa tablets should be stored at –20 °C, protected from light and moisture, in a sealed, airtight container. Tablets should not be dissolved or reconstituted unless required by a specific laboratory protocol. Refer to the COA for lot-specific storage and handling guidance. Standard laboratory protective equipment should be used during handling.

Where can I read more research about Dihexa (8mg) x 30 Tablets?

Researchers may consult the following peer-reviewed and scientific resources:

1. Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y. AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway. Brain Sci. 2021;11(11):1487. Published 2021 Nov 11. doi:10.3390/brainsci11111487
2. Weiss JB, Phillips CJ, Malin EW, Gorantla VS, Harding JW, Salgar SK. Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies. Ann Med Surg (Lond). 2021;71:102917. Published 2021 Oct 8. doi:10.1016/j.amsu.2021.102917
3. Cho KO, Lybrand ZR, Ito N, et al. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 2015;6:6606. Published 2015 Mar 26. doi:10.1038/ncomms7606
4. National Center for Biotechnology Information. PubChem Compound Summary for CID 129010512, N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide. https://pubchem.ncbi.nlm.nih.gov/compound/dihexa.

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.