DSIP 5mg

What is DSIP (5mg)?

Delta Sleep-Inducing Peptide (DSIP) is a synthetic nonapeptide composed of nine amino acids. Originally isolated from mammalian brain extracts in the 1970s, DSIP has been studied for its potential role in sleep modulation and neuroendocrine regulation. The 5mg presentation refers to a lyophilized, research-grade preparation with high analytical purity (typically ≥98% by HPLC). DSIP is being investigated in laboratory settings to better understand its biological activity and signaling interactions under controlled experimental conditions.

What are the key features of DSIP (5mg)?

DSIP (5mg) is provided as a research-grade, lyophilized nonapeptide manufactured under controlled laboratory conditions. Each batch undergoes analytical verification to confirm sequence accuracy, molecular weight, and purity prior to release. The 5mg vial format supports flexible preparation for a range of in vitro and preclinical research applications.

Key Features

• CAS Number: 62568-57-4
• Molecular weight: 848.8 g/mol
• Chemical Formula: C₃₅H₄₈N₁₀O₁₅
• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• Purity: ≥98% confirmed by HPLC
• Identity verification: Verified via mass spectrometry (MS) and HPLC
• For laboratory research use only
• Supports structured experimental design and preclinical evaluation

How is DSIP (5mg) synthesized?

DSIP is produced through solid-phase peptide synthesis (SPPS), a well-established method for assembling short peptide chains with high precision. This synthetic process ensures consistent sequence fidelity and reproducibility across production batches. After synthesis, the peptide is purified using high-performance liquid chromatography (HPLC) to meet the specified purity level. Mass spectrometry (MS) is used to confirm molecular identity. The final product is lyophilized to enhance stability under controlled laboratory storage conditions.

What is DSIP (5mg) being studied for? What are its possible benefits?

DSIP has been studied primarily for its involvement in sleep regulation, neuroendocrine modulation, and stress responses. Research has explored its relationship with sleep architecture, circadian rhythms, and hormonal regulation. Research areas include:

• Sleep architecture and delta-wave activity modulation
• Neuroendocrine regulation (ACTH, LH, GH secretion pathways)
• Circadian rhythm and locomotor pattern research
• Oxidative stress and cellular stress adaptation models
• Hormonal regulation in preclinical models

These findings are based on research observations and do not establish therapeutic effects or clinical efficacy in humans. DSIP continues to be studied for its potential regulatory role in neurochemical signaling and physiological balance, although its mechanisms remain only partially defined.

How does DSIP (5mg) work in research studies?

In laboratory studies, DSIP is thought to interact with signaling pathways involved in neuroendocrine and stress-related regulation. Although the exact mechanism remains under investigation, research suggests it may influence the activity of biological mediators linked to circadian rhythms and adaptive responses. Preclinical data indicate that DSIP may modulate oxidative stress markers and protein expression involved in cellular signaling. Some studies suggest that it may interact with hormonal regulatory systems, including stress-response pathways. These findings are derived from experimental models and do not indicate established therapeutic mechanisms.

What dosing information exists for DSIP (5mg)?

Dosing information for DSIP is limited to preclinical research models. Historical preclinical studies have evaluated DSIP at microgram-per-kilogram doses in rodent models, assessing sleep architecture, hormonal secretion, and neuroendocrine endpoints. In vitro research has used concentration-dependent exposure in cultured neuronal cells to observe changes in synaptic markers and signaling proteins. No standardized human dosing guidelines exist, as DSIP has not been approved for clinical use, and all available dosage data are derived from experimental laboratory or animal studies.

How should DSIP (5mg) be stored and handled?

DSIP (5mg) should be stored in its lyophilized form at –20 °C, protected from light and moisture. Maintaining a low-humidity environment is recommended to preserve structural stability. If reconstituted for experimental use, solutions should typically be stored at 2–8 °C and used within a limited timeframe, based on laboratory validation data. Repeated freeze-thaw cycles should be avoided, as they may affect peptide integrity. Proper laboratory handling procedures, including sterile technique and accurate volumetric measurement, are recommended to ensure experimental consistency.

Where can I read more research about DSIP (5mg)?

Researchers interested in further information may consult the following peer-reviewed sources:

1. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. doi:10.1111/j.1471-4159.2006.03693.x
2. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83-93. doi:10.1016/0149-7634(84)90022-8
3. Iyer KS, Marks GA, Kastin AJ, McCann SM. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. Proc Natl Acad Sci U S A. 1988;85(10):3653-3656. doi:10.1073/pnas.85.10.3653
4. Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003;24(2):307-311. doi:10.1016/s0196-9781(03)00040-8
5. Popovich IG, Voitenkov BO, Anisimov VN, et al. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. doi:10.1016/s0047-6374(03)00082-4

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.