
Ejal 40 and Nucleofill are two popular injectable treatments designed to enhance skin quality and structure. Ejal 40 focuses on deep hydration and improving elasticity with hyaluronic acid, while Nucleofill stimulates collagen production through polynucleotides, providing firming and anti-aging effects. Both products offer unique approaches to skin rejuvenation, addressing common skin concerns without surgery.
In this article, we will compare Ejal 40 vs Nucleofill, examining their formulations, benefits, and how they target skin aging.
Key Takeaways
- Ejal 40 and Nucleofill are injectable treatments designed to enhance skin quality.
- Ejal 40 primarily uses hyaluronic acid to boost hydration and elasticity.
- Nucleofill relies on polynucleotides for deeper skin repair and anti-aging effects.
- Ejal 40 results last approximately 6 to 9 months, while Nucleofill offers longer-lasting effects, up to 12 months.
- Both treatments are noted for boosting skin health and radiance, with results depending on individual skin needs and treatment goals.
- The choice between Ejal 40 and Nucleofill depends on specific skin concerns. Ejal 40 is best for those needing hydration and fine-line reduction, while Nucleofill is suited for patients seeking structural improvement and advanced anti-aging.
About: Doctor Medica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices in the market. If you’re looking to order Ejal 40 online for your practice, contact the Doctor Medica team today.
Understanding Ejal 40 and Nucleofill

Ejal 40 is a bio-revitalizing treatment that uses hyaluronic acid to deeply hydrate and enhance skin elasticity, promoting natural collagen production. It’s designed to help improve skin firmness and create a healthier, more youthful appearance, making it a great option for those wanting to combat early signs of aging and preserve a fresh complexion.
On the other hand, Nucleofill is a regenerative treatment that can repair and rejuvenate the skin. It delivers nucleotides, the building blocks of DNA and RNA, to the skin cells, promoting cell regeneration and boosting the skin’s natural healing processes. Nucleofill is ideal for those seeking a more profound and long-lasting anti-aging solution.
Formulation and Mechanism of Action
Ejal 40 uses a high concentration of hyaluronic acid, which attracts moisture to the skin and improves hydration. It contains 40mg of medium molecular weight hyaluronic acid (1200-1800 kDaltons) that can stimulate fibroblasts, promoting the production of collagen and elastin fibers. This process helps the skin maintain a youthful appearance by deeply hydrating and revitalizing areas prone to dryness and fine lines.
With Nucleofill, it uses natural polynucleotides that come from nucleic acids. These polynucleotides penetrate the deeper layers of the skin, stimulating collagen synthesis and promoting tissue repair. The result is improved elasticity, structure, and resilience, making Nucleofill particularly effective for addressing more advanced signs of aging and strengthening the skin’s overall structure.
Indications for Use
Ejal 40 is ideal for individuals beginning to notice signs of aging and want a gentle yet effective boost in skin hydration and elasticity. It is especially suitable for delicate skin areas, such as the undereye region, where Ejal 40 under eyes treatments are popular for reducing fine lines and improving skin texture.
Patients seeking to enhance moisture retention, reduce the appearance of fine lines, and add subtle plumpness to targeted areas are often good candidates for Ejal 40.
As for Nucleofill, it works best for patients with more advanced aging concerns, such as deeper wrinkles and a need for improved skin structure. Its regenerative formula is well-suited for larger facial areas and can also be used on the neck, décolletage, and hands.
Nucleofill’s cellular repair mechanism makes it ideal for patients looking to rejuvenate and strengthen the skin from within, achieving a lasting firmness and revitalized complexion.
Clinical Evidence and Efficacy
Studies have shown excellent results with skin boosters like Ejal 40. People noticed fewer lines and wrinkles after using it. The product works well for up to six to nine months, which makes patients happy because they see good changes in their skin for a long time.
Meanwhile, treatments like Nucleofill stand out because they last longer than many treatments. Its high polynucleotide level helps skin look better by making it smoother and more hydrated and reducing fine lines and wrinkles.
Duration of Results and Safety Profiles
Ejal 40 results can last six to nine months, making it appealing for patients seeking long-term skin improvements like smoother skin and reduced fine lines. Known for its well-researched safety profile, Ejal 40 is versatile and suitable for use on various facial areas requiring rejuvenation. Its extended effectiveness and adaptability have positioned it as a dependable option for individuals interested in sustained facial enhancement.
Nucleofill offers even longer-lasting results, often up to twelve months, which appeals to those seeking enduring skin improvement. Formulated with a high concentration of polynucleotides, Nucleofill provides substantial skin benefits that can surpass those of other treatments like Rejuran. This makes Nucleofill a strong choice for patients focused on maintaining skin vitality and reducing signs of aging for an extended period.
Case Studies and Patient Experiences
The face appears tired in this before-and-after comparison of a patient who received Ejal 40 treatments. The patient has noticeable fine lines, uneven skin tone, and mild sagging, especially around the cheeks and jawline. The skin texture is rough, and the overall appearance lacks vibrancy.

Image Courtesy of Dr. Goodwin
After the treatment, the face looks refreshed and revitalized, with smoother skin texture, reduced fine lines, and a more even skin tone. The cheeks and jawline appear lifted, giving the face a youthful, glowing appearance.
For this Nucleofill before-and-after comparison, the patient’s facial skin shows signs of dullness and dehydration, with visible pores and early signs of aging, like crow’s feet and faint wrinkles around the mouth.

Image Courtesy of Skin Medicine
After the treatment, the patient’s face is visibly brighter, with plumped, hydrated skin and reduced pore visibility. Fine lines are nearly gone, and the overall complexion appears more radiant and healthy, enhancing the face’s natural contours.
Conclusion
Ejal 40 and Nucleofill are both effective options for rejuvenating the skin. Ejal 40 is particularly beneficial for reducing fine lines, while Nucleofill enhances skin hydration and smoothness. Both treatments stimulate collagen production, supporting long-term skin health and radiance.
With results lasting from six to twelve months, the choice between Ejal 40 and Nucleofill ultimately depends on your skin’s specific needs. Consulting with a skincare professional can help you select the best option for achieving a youthful, refreshed appearance.
FAQs
1. What are the main differences between Ejal 40 and Nucleofill?
Ejal 40 uses hyaluronic acid to improve skin hydration and elasticity, ideal for reducing fine lines. Nucleofill contains polynucleotides that focus on deeper skin repair and collagen stimulation, making it suitable for more advanced aging concerns.
2. How long do the effects of Ejal 40 and Nucleofill last?
Ejal 40 results generally last 6 to 9 months, while Nucleofill’s effects can last up to 12 months, depending on skin type and aftercare practices.
3. Which areas can Ejal 40 and Nucleofill treat?
Both treatments can rejuvenate the face, neck, décolletage, and hands. Ejal 40 is particularly popular for under-eye treatments, while Nucleofill works best for larger areas needing firming and hydration.
References
Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermato-Endocrinology. 2012;4(3):308-319. doi:10.4161/derm.22804
Beauty Bar. (n.d.). Ejal40 revitalising treatment in Hertfordshire. Retrieved November 4, 2024, from https://www.beauty-bar.co.uk/ejal40-revitalising-treatment-in-hertfordshire/
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