Rejuran vs Sculptra – A Thorough Comparison

According to the American Society of Plastic Surgeons (ASPS), non-surgical facial treatments have surged by 200% over the past decade. This trend underscores the growing preference for minimally invasive procedures to achieve youthful, rejuvenated skin.

Among these treatments, Rejuran and Sculptra stand out for their unique approaches to skin rejuvenation. Rejuran, derived from salmon DNA, focuses on skin regeneration and repair, while Sculptra, made from poly-L-lactic acid, stimulates collagen production to restore facial volume. Both treatments offer promising results, but their mechanisms and outcomes differ significantly.

This article will delve into the science behind Rejuran and Sculptra, compare their benefits and drawbacks, and help you determine which treatment might best suit your needs.

Key Takeaways

• Rejuran and Sculptra are popular non-surgical cosmetic treatments, each offering unique benefits for skin rejuvenation.
• Rejuran focuses on skin healing and repair using polynucleotides (PN) from salmon DNA, improving skin texture and elasticity.
• Sculptra promotes collagen production with poly-L-lactic acid (PLLA), targeting volume loss and deeper wrinkles.
• Both treatments are effective but differ in their application areas, mechanisms of action, and treatment outcomes.
• The choice between Rejuran and Sculptra depends on individual skin concerns and desired results, such as smoother skin versus volume restoration.

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Understanding Rejuran and Sculptra

Rejuran is an injectable treatment made from polynucleotides (PN) derived from salmon DNA. Unlike traditional fillers, Rejuran does not contain hyaluronic acid. It works by stimulating the production of collagen and elastin, helping to rejuvenate the skin, improve its texture, and enhance elasticity.

While effective, patients and healthcare professionals must consider Rejuran’s FDA approval before deciding on and committing to this treatment.

On the other hand, Sculptra is a cosmetic injectable made from poly-L-lactic acid (PLLA). This treatment addresses volume loss and deep wrinkles by encouraging the gradual production of collagen. Over time, Sculptra helps restore the skin’s structure and smoothness, making it a popular choice for those seeking long-term, natural-looking improvements in their skin’s appearance.

Mechanism of Action

Understanding how Rejuran and Sculptra work is key to selecting the right treatment for your skin concerns. Both injectables focus on rejuvenation but operate through different mechanisms to achieve their effects.

• Rejuran: Rejuran uses polynucleotides (PN), derived from salmon DNA, to stimulate the skin’s natural healing process. These short DNA fragments encourage the production of collagen and elastin, leading to improved skin texture, elasticity, and overall health. By boosting cell regeneration, Rejuran helps restore a youthful, glowing complexion.
• Sculptra: In contrast, Sculptra relies on poly-L-lactic acid (PLLA) to address volume loss and deep wrinkles. Once injected, Sculptra works beneath the skin to gradually stimulate collagen production over time. This progressive approach helps rebuild the skin’s structure, offering natural-looking results that continue to improve for several months post-treatment.

Efficacy and Results

Both Rejuran and Sculptra are highly effective in skin rejuvenation, but their results vary due to their different mechanisms of action.

• Rejuran focuses on healing and regenerating the skin, leading to noticeable improvements in skin texture, elasticity, and fine lines within a few weeks. Patients often report a healthier, more radiant complexion with smoother skin.
• Sculptra is designed to tackle volume loss and deep wrinkles by stimulating long-term collagen production. While results are gradual, patients typically see significant improvements in facial volume and skin firmness over several months, with full results taking up to 6 months to appear. Sculptra’s effects can last up to two years, making it ideal for those seeking more structural enhancement.

Suitable Treatment Areas

Both Rejuran and Sculptra are versatile treatments, but they target different areas of concern depending on their strengths.

Rejuran

• Face: Rejuran is commonly used to improve overall skin texture, reduce fine lines, and enhance skin elasticity. It is particularly effective for areas with visible signs of aging, such as the forehead, cheeks, and around the eyes.
• Neck: It can also be applied to the neck to address sagging skin and fine lines, promoting a smoother and more youthful appearance.
• Hands: Rejuran is sometimes used on the hands to rejuvenate the skin and reduce the appearance of aging.

Sculptra

• Cheeks: Sculptra is ideal for restoring volume in the cheeks, providing a fuller and more youthful look.
• Nasolabial Folds: It reduces deep lines and wrinkles around the nose and mouth, known as nasolabial folds.
• Jawline: Sculptra can enhance the jawline by adding volume and definition, helping to create a more contoured appearance.
• Temples: It is also used to fill in hollow temples, which can contribute to a more balanced and youthful facial structure.

Conclusion

Rejuran and Sculptra both offer effective solutions for enhancing skin appearance, but they work in distinct ways. Rejuran excels in improving skin texture and elasticity, making it ideal for those seeking smoother, firmer skin. On the other hand, Sculptra is perfect for filling deep lines and restoring facial volume, giving the face a fuller, more youthful look.

Ultimately, the choice between the two depends on your skin’s specific needs. Both treatments rejuvenate the skin without the need for surgery, so whether you’re looking to reduce wrinkles or improve overall texture, you can find a solution that suits your goals.

FAQs

1. What is the primary difference between Rejuran and Sculptra?

Rejuran uses polynucleotides from salmon DNA to repair and regenerate the skin, improving texture and elasticity. Meanwhile, Sculptra uses poly-L-lactic acid to stimulate collagen production, primarily addressing volume loss and deep wrinkles.

2. How long do results from Rejuran and Sculptra last?

Rejuran results can last up to six months or more, depending on the skin’s condition. Sculptra’s effects typically last up to two years, with gradual improvements over several months.

3. Which treatment is better for reducing wrinkles?

Sculptra is generally better for deep wrinkles and volume loss, while Rejuran focuses more on improving skin texture and fine lines.

4. Are Rejuran and Sculptra FDA-approved?

Sculptra is FDA-approved for aesthetic treatments, whereas Rejuran is not yet FDA-approved in the United States.

References

Farber SE, Epps MT, Brown E, Krochonis J, McConville R, Codner MA. A review of nonsurgical facial rejuvenation. Plastic and Aesthetic Research. 2020;2020. doi:10.20517/2347-9264.2020.152

U.S. Food and Drug Administration. (n.d.). FDA-approved dermal fillers. FDA. https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/fda-approved-dermal-fillers