MT-2 (Melanotan 2)

What is MT-2 (Melanotan 2)?

Melanotan II (MT-2) is a fully synthetic peptide derived from the hormone α-Melanocyte-Stimulating Hormone (α-MSH). It belongs to a class of small, cyclic peptides known as heptapeptides, composed of seven amino acids arranged into a stable lactam ring structure that enhances structural integrity and enzymatic resistance. This structural configuration contributes to its receptor-binding characteristics within melanocortin pathways studied in laboratory research models. In research environments, MT-2 is supplied as a high-purity (≥95%), lyophilized white powder. The freeze-dried format helps preserve peptide stability during storage and transport, ensuring reproducibility in controlled scientific studies.

Product Specifications

• Product Name: Melanotan II (MT-2)
• Synonym: MT-2
• CAS Number: 121062-08-6
• Chemical Formula: C₅₀H₆₉N₁₅O₉
• Molecular Weight: 1024.198 g/mol
• Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
• Structure Type: Cyclic heptapeptide
• Purity: ≥95% (research grade)
• Appearance: White lyophilized powder

What are the key features of MT-2 (Melanotan 2)?

It is available in research-grade formulations, including the melanotan 2 10 mg vial, designed to support precision in laboratory workflows. The peptide's formulation and analytical consistency make it suitable for biochemical and melanogenesis studies. Key features include:

• High-purity formulation (often ≥95%) confirmed by HPLC and mass spectrometry
• Supplied as a sterile, lyophilized (freeze-dried) white powder for research use
• Heptapeptide structure supporting stable research outcomes
• Standard vial sizes, including the melanotan 2 10 mg vial, ideal for experimental setups
• Analytical verification including advanced chromatographic techniques
• Each batch is accompanied by documentation regarding its synthetic pathway and sequence integrity
• For laboratory research use only

How is MT-2 (Melanotan 2) synthesized?

MT-2 is produced through solid-phase peptide synthesis (SPPS), a controlled method in which the peptide is built one amino acid at a time on a solid resin backbone. This technique ensures precise incorporation of each amino acid residue, which is crucial for replicating the stable structure of the melanotan 2 peptide. After assembly, the peptide undergoes a cyclization process, where the chain is closed into a ring structure by linking the N-terminal and C-terminal ends. This ring formation is a critical feature of MT-2 as it increases the peptide's stability and resistance to enzymatic degradation, making it highly effective for research use. The peptide undergoes further purification using HPLC, which removes any impurities and confirms the molecular weight and purity of the compound. Finally, mass spectrometry and amino acid analysis are employed to verify the identity and integrity of the peptide. The product is then lyophilized into a stable, white to off-white powder. This careful synthesis and analytical process ensures that MT-2 for research meets the required standards for laboratory investigation.

What is MT-2 (Melanotan 2) being studied for? What are its possible benefits?

MT-2 (Melanotan 2) is primarily studied for its role in melanogenesis, the biological process responsible for the production of melanin in skin cells, or melanocytes. It is widely used to investigate how MT-2 influences pigmentation pathways, particularly those regulated by α-MSH. Beyond pigmentation studies, MT-2 has been explored in relation to:

• Lipid metabolism and energy expenditure, with research focusing on its potential role in metabolic regulation
• Inflammatory responses, as some studies suggest MT-2 may have effects on inflammatory cytokines
• Angiogenesis, particularly in relation to blood vessel formation, in preclinical models
• Tissue repair, especially in studies evaluating the role of MT-2 in wound healing and regeneration

However, these findings remain exploratory, and no confirmed therapeutic benefits have been established. All current evidence applies only to preclinical models and in-vitro research and does not represent proven clinical outcomes. Researchers studying the melanotan 2 tanning peptide typically examine these pathways within controlled environments.

How does MT-2 (Melanotan 2) work in research studies?

In laboratory experiments, MT-2 is believed to function by mimicking the activity of α-MSH, a natural hormone that signals melanocytes to produce pigment. When exposed to MT-2, melanocytes activate pathways involved in melanin synthesis, allowing researchers to study changes in pigmentation-related markers and the regulation of melanogenesis. MT-2 functions as a non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). MC1R activation is responsible for melanogenesis (pigmentation), while MC4R activation (and potentially MC3R) is associated with additional cellular effects studied in preclinical research. By activating this receptor, MT-2 increases the production of melanin, the pigment responsible for skin color. Additionally, some studies also explore how MT-2 interacts with other cellular processes, such as those connected to inflammation, cellular stress responses, and tissue-level signaling. These mechanisms are still under investigation, and the exact pathways by which MT-2 exerts its effects may vary depending on the model or experimental design.

What dosing information exists for MT-2 (Melanotan 2)?

Dosing ranges for MT-2 appear in early-stage research and are not standardized. Reported values from preclinical models and limited human studies typically range from 0.01 mg/kg to 0.03 mg/kg, with some experiments administering MT-2 by subcutaneous injection every other day. Earlier experimental protocols reported a single daily dose of approximately 0.025 mg/kg/day, although higher doses were associated with a greater likelihood of adverse reactions. These figures reflect preclinical and limited human studies and should not be viewed as guideline recommendations. No approved dosing instructions for MT-2 exist in clinical settings. Experts using MT-2 for research should rely solely on peer-reviewed studies or institutional research standards when determining experimental concentrations.

How should MT-2 (Melanotan 2) be stored and handled?

Store at –20°C, away from light, heat, and moisture to maintain structural integrity. The lyophilized powder is stable when frozen and protected from environmental exposure. After reconstitution, the solution is typically stored at 2–8°C and used promptly to minimize degradation. Freezing reconstituted solutions is not recommended, as freeze-thaw cycles can degrade peptide structure. Standard aseptic handling procedures should be followed to maintain sample integrity throughout the study. The peptide should also be kept desiccated (dry), as it is sensitive to moisture.

Where can I read more research about MT-2 (Melanotan 2)?

For more information, consult these credible resources:

1. AC-NLE-Cyclo[ASP-His-D-Phe-Arg-TRP-Lys]-NH2. PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/14560360
2. Mun Y, Kim W, Shin D. Melanocortin 1 receptor (MC1R): Pharmacological and therapeutic aspects. International Journal of Molecular Sciences. 2023;24(15):12152. doi:10.3390/ijms241512152
3. Peters B, Hadimeri H, Wahlberg R, Afghahi H. Melanotan II: a possible cause of renal infarction: review of the literature and case report. CEN Case Reports. 2020;9(2):159-161. doi:10.1007/s13730-020-00447-z
4. Brennan R, Wells JG, Van Hout MC. An unhealthy glow? A review of melanotan use and associated clinical outcomes. Performance Enhancement & Health. 2014;3(2):78-92. doi:10.1016/j.peh.2015.06.001
5. Melanotan-2 (MT-II): Comprehensive Research Monograph | Peptide Biologix. https://peptidebiologix.com/melanotan-2

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.