NUCLEOFILL™ MEDIUM

NUCLEOFILL™ MEDIUM is a 2% polynucleotide gel formulated for biorestructuring of the skin with mild aging signs. This innovative treatment uses highly purified natural-origin polynucleotides with a molecular weight of 2,500 kDa, offering deep dermal renewal, hydration, antioxidant protection, and fibroblast stimulation. It acts on three levels—dermo-epidermal, vascular, and deep tissue layers—to improve skin tone, elasticity, and volume.

Recommended for preventive and curative applications, NUCLEOFILL™ MEDIUM helps regenerate the dermis, smooth out fine wrinkles, treat shallow scars, and prepare the skin for more intensive procedures. It is CE-certified and biocompatible, making it suitable for long-term skin rejuvenation protocols.

NUCLEOFILL™ MEDIUM is administered by intradermal or deep dermal injection using multipoint or 5-point techniques.

Key features:

• Provides hydration, lifting, and dermal regeneration
• Suitable for mild to moderate aging signs

Administration guidelines:

• Use 30G 12 mm needle, included in package
• Inject 0.1 mL per point, spacing points ~1 cm apart
• Common techniques:
  • 5-point bio-restructuring
  • Multi-injection deep dermal
• Recommended treatment cycle:
  • Day 0, 15, 30, 45
  • Maintenance: every 4–6 months

Indications:

• Bio-restructuring of dermis with mild laxity
• Dehydrated or dull skin
• Fine lines and shallow scarring
• Pre-surgical preparation
• Preventive anti-aging care

Contraindications:

• Hypersensitivity to polynucleotides
• Pregnancy or breastfeeding
• Autoimmune disorders
• Skin infections or inflammatory conditions at injection site

Side effects may include:

• Temporary swelling, redness, pain, or bruising
• Rare: allergic reaction, nodules, or inflammatory response

Each syringe contains:

• 2% polynucleotide gel
• Molecular weight: 2,500 kDa
• pH: 6.8–7.2
• Viscosity: 28–43 Pa·s

Polynucleotides are derived from natural, purified sources, free from allergens or animal proteins.

Each box contains:

• 1 × 1.5 mL pre-filled syringe
• 2 × 30G 12 mm needles
• Sterile, single-use packaging
• Instructions for use

Yes, though side effects are typically mild and short-lived.

Common side effects:

• Injection site redness
• Mild swelling or bruising
• Temporary discomfort or tightness

Rare complications:

• Lumps, delayed inflammation, or hypersensitivity
• Vascular events (rare; proper technique reduces risk)

Storage conditions:

• Store at 2°C to 25°C
• Keep in original packaging, away from heat and light
• Do not freeze
• Use immediately after opening