TB500(Thymosin B4 Acetate) (10 mg)

What is Thymosin Beta 4 (TB500) (10mg)?

Thymosin Beta 4 (TB500) (10mg) is a synthetic peptide analog of the naturally occurring Thymosin Beta-4 protein, found in many mammalian tissues. It consists of 43 amino acids and is classified as a regulatory peptide involved in cellular migration and cytoskeletal dynamics in laboratory research models.

• Chemical Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
• Molecular Weight: 4963 g/mol
• CAS Number: 77591-33-4
• Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

Thymosin Beta 4 (TB500) (10mg) is produced with high purity, verified using techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). It has been studied for its potential involvement in tissue remodeling, cell migration, and cytoskeletal regulation in experimental environments.

What are the key features of Thymosin Beta 4 (TB500) (10mg)?

• Synthetic peptide composed of 43 amino acids
• Purity typically ≥95%, verified through HPLC and mass spectrometry
• Supplied as 10 mg lyophilized peptide in a sealed research vial
• Studied in cell migration, cytoskeletal dynamics, and tissue repair research
• For laboratory research use only

How is Thymosin Beta 4 (TB500) (10mg) synthesized?

Thymosin Beta 4 (TB500) (10mg) is synthesized using solid-phase peptide synthesis (SPPS), a widely used laboratory method for constructing peptides with precise amino acid sequences. In SPPS, amino acids are sequentially added to a solid support to form the complete peptide chain. After synthesis, the peptide undergoes purification through high-performance liquid chromatography (HPLC) to ensure high purity. Mass spectrometry (MS) is used for identity verification, confirming the peptide’s molecular weight and structure. Finally, the peptide is lyophilized to maintain stability during storage and transport.

What is Thymosin Beta 4 (TB500) (10mg) being studied for? What are its possible benefits?

Thymosin Beta 4 (TB500) (10mg) has been studied in laboratory environments for its role in cellular migration, tissue remodeling, and cytoskeletal organization. The peptide interacts with actin proteins, which are involved in regulating cell movement and structural integrity. Research areas involving Thymosin Beta 4 include:

• Cell migration and cytoskeletal organization studies
• Angiogenesis research models
• Tissue repair and regeneration investigations
• Inflammatory signaling pathway research
• Cell differentiation and wound-healing biology studies

Laboratory studies suggest that Thymosin Beta 4 (TB500) may influence processes such as reactive oxygen species regulation, mitochondrial efficiency, and cellular energy regulation. These observations remain under investigation and are not yet established therapeutic outcomes.

How does Thymosin Beta 4 (TB500) (10mg) work in research studies?

In laboratory studies, Thymosin Beta 4 (TB500) (10mg) is investigated for its ability to bind to actin, a protein that forms part of the cellular cytoskeleton. By interacting with actin, the peptide influences processes related to cell movement, structural organization, and intracellular signaling. Researchers examine how this interaction may affect pathways involved in tissue repair and cell migration. These studies aim to better understand how actin-binding peptides contribute to cellular communication and structural adaptation in biological systems. The exact mechanisms are still under investigation in experimental research environments.

What dosing information exists for Thymosin Beta 4 (TB500) (10mg)?

Research involving Thymosin Beta 4 (TB500) (10mg) has primarily been conducted in preclinical laboratory settings, including cell culture experiments and animal models. In vitro research typically evaluates peptide activity at nanomolar to micromolar concentrations to observe cellular responses and signaling activity. In animal models, dosing ranges have been explored on a microgram-per-kilogram (µg/kg) scale, depending on the research objectives and experimental design. As Thymosin Beta 4 (TB500) is a research compound, no standardized human dosing guidelines exist, and its use is limited to laboratory research settings.

How should Thymosin Beta 4 (TB500) (10mg) be stored and handled?

Proper storage conditions are crucial for maintaining peptide stability and ensuring reliable research results. Thymosin Beta 4 (TB500) (10mg) is supplied as a lyophilized peptide powder, which helps extend shelf life when stored properly.

• Store at –20 °C or lower for long-term preservation.
• Protect from light, heat, and moisture.
• Keep vials sealed until ready for laboratory use.
• After reconstitution, store at 2–8 °C for short-term use.
• Avoid repeated freeze-thaw cycles to preserve peptide integrity.
• Refer to the batch certificate of analysis for batch-specific stability data.

Where can I read more research about Thymosin Beta 4 (TB500) (10mg)?

Researchers interested in Thymosin Beta-4 and actin-binding peptide research may consult the following publications:

1. Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. doi:10.1046/j.1523-1747.1999.00708.x
2. Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I. Thymosin beta4 and cardiac repair. Ann N Y Acad Sci. 2010;1194:87-96. doi:10.1111/j.1749-6632.2010.05468.x
3. Smart N, Risebro CA, Melville AA, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177-182. doi:10.1038/nature05383
4. Kleinman HK, Sosne G. Thymosin β4 Promotes Dermal Healing. Vitam Horm. 2016;102:251-275. doi:10.1016/bs.vh.2016.04.005

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.