Humanin 10mg

What is Humanin (10mg)?

Humanin (10mg) is a synthetic peptide corresponding to a small mitochondrial-derived signaling protein originally identified in human cells. It belongs to a group of peptides known as mitochondrial-derived peptides, which are being investigated for their role in cellular stress response and metabolic regulation.

• Chemical Formula: C₁₁₉H₂₀₄N₃₄O₃₂S₂
• Molecular Weight: 2687.2 g/mol
• Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
• CAS Number: 330936-69-1

This peptide fragment is typically manufactured to high purity levels, verified through analytical testing. Humanin has been studied in laboratory models investigating mitochondrial signaling, cellular protection pathways, and metabolic processes. These investigations remain experimental.

What are the key features of Humanin (10mg)?

• High research-grade purity (typically ≥95%, verified analytically)
• Supplied as a 10 mg lyophilized peptide in a sealed vial
• Peptide sequence consisting of 24 amino acids
• Studied in mitochondrial signaling and metabolic research models
• Shelf life of approximately 24 months under recommended storage conditions
• For laboratory research use only

How is Humanin (10mg) synthesized?

Humanin (10mg) is produced using solid-phase peptide synthesis (SPPS), a method that enables precise assembly of short peptide sequences from individual amino acid units. This technique ensures accurate production of the full 24-amino acid Humanin sequence used in laboratory research. After synthesis, purification is typically performed using high-performance liquid chromatography (HPLC) to achieve high purity. The peptide's molecular weight and structural identity are confirmed using mass spectrometry (MS). The purified peptide is then lyophilized to enhance its stability during storage and transport.

What is Humanin (10mg) being studied for? What are its possible benefits?

Humanin (10mg) has been studied in laboratory research focused on mitochondrial function and cellular stress responses. Research investigations have explored its involvement in:

• Mitochondrial signaling research
• Metabolic regulation studies
• Neurodegenerative disease research models
• Cell survival and apoptosis investigations
• Oxidative stress response studies

In experimental systems, Humanin has been studied for its potential influence on pathways related to cellular protection and metabolic regulation. These potential biological effects are still under investigation, based on laboratory findings, rather than established clinical outcomes.

How does Humanin (10mg) work in research studies?

In laboratory studies, Humanin (10mg) is being researched for its role as a signaling peptide involved in mitochondrial communication and cellular stress response pathways. Mitochondrial-derived peptides are believed to function as regulatory molecules that influence cellular metabolism and survival signals. Humanin may interact with cellular signaling systems that regulate responses to metabolic stress or damage. Experimental studies have examined its potential role in modulating apoptosis-related pathways and cellular defense mechanisms. These mechanisms are still investigational and are primarily studied in cell culture and animal models.

What dosing information exists for Humanin (10mg)?

Research involving Humanin has primarily been conducted in cell culture and animal models. In vitro studies typically evaluate nanomolar to micromolar concentrations to assess cellular responses related to mitochondrial signaling and metabolic stress. In animal models, Humanin and related analogs have been studied at microgram per kilogram (µg/kg) dosing ranges, depending on experimental design. Dosing schedules vary widely based on research objectives and the biological systems under investigation. There are no established human dosing guidelines for Humanin (10mg), as it is intended solely for laboratory research use.

How should Humanin (10mg) be stored and handled?

Humanin (10mg) should be stored at 2–8 °C for routine laboratory handling. For long-term preservation, storage at ≤–20 °C is recommended to maintain peptide stability. Protect the vial from excessive light and moisture. After reconstitution with sterile laboratory-grade solvent, short-term storage at 2–8 °C is typically recommended. Avoid repeated freeze–thaw cycles, as these may affect peptide stability. The product generally maintains stability for approximately 24 months when stored under recommended conditions. Appropriate laboratory protective equipment should be used when handling the material. Disposal should follow institutional biosafety and chemical safety guidelines.

Where can I read more research about Humanin (10mg)?

1. Hashimoto Y, Niikura T, Tajima H, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A. 2001;98(11):6336-6341. doi:10.1073/pnas.101133498
2. Muzumdar RH, Huffman DM, Atzmon G, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009;4(7):e6334. Published 2009 Jul 22. doi:10.1371/journal.pone.0006334
3. Armas A, Sonois V, Mothes E, Mazarguil H, Faller P. Zinc(II) binds to the neuroprotective peptide humanin. J Inorg Biochem. 2006;100(10):1672-1678. doi:10.1016/j.jinorgbio.2006.06.002
4. National Center for Biotechnology Information. PubChem Compound Summary for CID 16131438, Humanin. https://pubchem.ncbi.nlm.nih.gov/compound/Humanin

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.