What Is Lanluma – All About the Dermal Filler

Collagen, the primary structural protein in the skin, plays a crucial role in maintaining elasticity, firmness, and overall dermal integrity. However, from the mid-20s onward, collagen production declines by approximately 1% each year, leading to visible signs of aging such as wrinkles, volume loss, and skin laxity.

To address this natural decline, biostimulatory treatments have emerged, aiming to restore the skin’s structure by enhancing endogenous collagen synthesis. Among these, Lanluma, a poly-L-lactic acid (PLLA)-based dermal filler, stands out for its ability to stimulate gradual, long-lasting improvements in skin quality and volume.

This article will explore what Lanluma is, how it differs from traditional fillers, and why it is gaining recognition in aesthetic medicine. We’ll examine its mechanism of action, clinical benefits, potential risks, and key considerations for those seeking a regenerative approach to facial and body rejuvenation.

Key Takeaways

• Lanluma is a poly-L-lactic acid (PLLA)-based dermal filler that stimulates collagen production. It offers gradual and long-lasting improvements in skin firmness, elasticity, and volume.
• Unlike hyaluronic acid fillers that provide instant volume, Lanluma activates fibroblasts to naturally regenerate collagen, resulting in subtle, natural-looking enhancements over time.
• Lanluma is uniquely suited for both facial and body treatments, including non-surgical buttock augmentation, hip dips, and thigh contouring. It has specialized formulations for different areas.
• Treatment plans typically involve multiple sessions spaced 4–6 weeks apart, with full results developing over several months and lasting up to two years.
• Lanluma’s safety profile is well-established. Common side effects, such as swelling, bruising, and tenderness, are mild and temporary. Proper patient selection and technique are crucial for minimizing risks.
• As a regenerative biostimulator, Lanluma provides a long-term solution for those seeking natural, progressive rejuvenation without the obvious signs of cosmetic intervention.

About: Doctor Medica is your trusted supplier of top-quality dermal fillers, viscosupplements, and more for your medical practice. We offer genuine products from leading brands at the lowest prices. Contact Doctor Medica today to order Lanluma online for your practice.  

What Makes Lanluma Different from Other Dermal Fillers

Lanluma distinguishes itself from conventional dermal fillers through its unique mechanism of action. While hyaluronic acid (HA) fillers create immediate volume by physically occupying space with gel-like substances, Lanluma operates on a deeper biological level. It stimulates fibroblasts, encouraging the production of new collagen, which gradually improves skin firmness, volume, and elasticity from within.

A defining feature of Lanluma is its suitability for larger treatment areas, a capability that sets it apart from most HA fillers. It is commonly utilized for non-surgical buttock augmentation, hip dip correction, and thigh contouring—applications beyond the scope of traditional fillers, which are generally limited to facial volumization.

For patients comparing Lanluma vs Sculptra, it’s important to note that while both are PLLA-based collagen stimulators, Lanluma is approved for a broader range of body treatments within the UK and EU. Additionally, Lanluma’s reconstitution protocol allows for higher dilution volumes, providing enhanced flexibility for treating larger surface areas while maintaining consistency and safety.

These differentiators make Lanluma an attractive option for individuals seeking natural-looking, long-lasting body contouring results without invasive surgery.

Clinical Indications and Target Treatment Areas for Lanluma

Lanluma is designed for versatile applications across both the face and body, offering targeted solutions through its two specialized formulations:

• Lanluma V for facial treatments, tailored for delicate areas requiring precision and subtle enhancement.
• Lanluma X for body contouring, formulated for higher injection volumes and deeper tissue applications.

Primary treatment areas include:

• Face: cheeks, temples, jawline, nasolabial folds, and areas affected by age-related volume loss.
• Body: buttocks, hips, thighs, upper arms, and décolletage, targeting concerns like skin laxity, cellulite, and contour irregularities.

Treatment plans are typically structured with 2 to 4 sessions, spaced 4–6 weeks apart for optimal and sustainable results. The exact number of sessions and vials used is customized based on patient anatomy, skin quality, and aesthetic goals. This tailored approach ensures gradual, natural enhancements with results that evolve over time.

The Science Behind Lanluma’s Mechanism of Action

At the core of Lanluma’s efficacy is poly-L-lactic acid (PLLA), a biocompatible, biodegradable synthetic polymer with over 30 years of medical use. Its history includes applications in dissolvable sutures and soft tissue implants, underscoring its safety and reliability in biostimulation therapies.

Upon injection into the dermal or subcutaneous layers, Lanluma’s PLLA particles initiate a controlled, low-grade inflammatory response. This response activates fibroblasts, leading to the production of new collagen fibers. Unlike hyaluronic acid fillers that deliver instant volume, Lanluma’s effects develop gradually as the PLLA microspheres metabolize and the body’s own collagen network replaces them.

This collagen remodeling process results in:

• Enhanced skin thickness and firmness.
• Restored volume in targeted areas.
• Improved texture and elasticity.

The outcome is a smooth, balanced, and natural look, as the new collagen integrates seamlessly into the tissue without the artificial feel of traditional fillers. This regenerative approach makes Lanluma ideal for patients seeking subtle, yet impactful aesthetic improvements.

Lanluma Safety Profile and Contraindications

When administered by trained professionals, Lanluma maintains a strong safety profile, supported by its CE-mark approval in the UK and EU. Clinical studies and post-market data affirm its efficacy and tolerability, particularly for facial rejuvenation and body contouring procedures.

Lanluma’s common side effects include:

• Temporary swelling at the injection site.
• Mild bruising and localized tenderness.
• Occasional redness or itching, typically resolving within a few days.

However, Lanluma is contraindicated in patients with:

• Active skin infections at the treatment site.
• Autoimmune diseases affecting collagen production.
• Pregnancy or breastfeeding status.
• Known allergies to PLLA or related components.

Comprehensive patient assessment prior to treatment is essential to ensure suitability. Proper injection techniques and adherence to the recommended product preparation protocols significantly minimize risks and enhance treatment success.

Conclusion

Understanding Lanluma in depth reveals why it is more than a conventional filler—it is a collagen biostimulator promoting natural, gradual rejuvenation through the body’s regenerative capabilities. Lanluma provides an effective, long-lasting alternative to immediate-volume fillers, appealing to patients seeking subtle yet noticeable enhancements, whether for facial contouring or body sculpting.

Its ability to address larger treatment areas, combined with a strong safety record, makes Lanluma a valuable option in modern aesthetic practices. When administered with precision and complemented by proper aftercare, Lanluma delivers natural-looking, long-lasting results, making it a trusted choice for both patients and practitioners alike.

FAQs

1. How long do Lanluma results last?

Lanluma results can last up to two years. Patients may need maintenance treatments depending on the area treated and patient factors such as age and metabolism.

2. Is Lanluma better than hyaluronic acid fillers?

Lanluma offers longer-lasting and more natural results through collagen stimulation. However, practitioners may recommend HA fillers for immediate volume or in delicate areas like the lips.

3. Does Lanluma work for all skin types?

Yes, Lanluma is suitable for all skin types. However, practitioners should fully consult to rule out contraindications and tailor treatments accordingly.

4. How soon can I see results from Lanluma?

Initial results begin around 6–8 weeks after treatment. Full effects develop over 3–6 months as collagen builds beneath the skin.

References

He T, Fisher GJ, Kim AJ, Quan T. Age-related changes in dermal collagen physical properties in human skin. PLoS ONE. 2023;18(12):e0292791. doi:10.1371/journal.pone.0292791

Safe poly-L-lactic acid collagen stimulator filler. Lanluma. https://lanluma.com/lanluma-journey/

Wu L, Salti G. Combined Forehead and Temporal Lifting: An Innovative Approach to Lanluma V Treatment. J Cosmet Dermatol. 2025;24(1):e16583. doi:10.1111/jocd.16583