Follistatin 344 (95%) 1mg

What is Follistatin 344 (95%) (1mg)?

Follistatin 344 (95%) (1mg) is a recombinant protein corresponding to the 344–amino acid isoform of human follistatin, a naturally occurring glycoprotein involved in regulating growth factors. Commonly referred to as FST or Activin-Binding Protein, it is classified as a regulatory binding protein rather than a short peptide fragment. The full-length Follistatin 344 precursor contains 344 amino acids, which are processed into biologically active forms in physiological systems. The approximate molecular weight of the expressed protein backbone is 37–38 kDa (commonly listed as ~3780 g/mol, though full-length glycosylated forms are larger depending on the expression system). This product is supplied at ≥95% purity, verified through analytical testing. Follistatin 344 has been studied for its roles in regulating activin signaling and modulating growth factors in laboratory models.

What are the key features of Follistatin 344 (95%) (1mg)?

Follistatin 344 (95%) (1mg) is produced in a research-grade recombinant format suitable for controlled laboratory applications.

• Recombinant human Follistatin 344 protein
• ≥95% purity (analytically verified)
• Supplied as 1 mg of lyophilized protein in a sealed vial
• Studied in growth factor and muscle biology research models
• Recommended storage: 2–8 °C (≤–20 °C for long-term storage)
• For laboratory research use only
• Intended exclusively for in vitro and preclinical research investigations

How is Follistatin 344 (95%) (1mg) synthesized?

Follistatin 344 (95%) (1mg) is produced using recombinant DNA technology. The human FST gene sequence encoding the 344–amino acid isoform is inserted into an appropriate expression system, such as mammalian or bacterial host cells, to generate the protein under controlled laboratory conditions. Following expression, purification is performed using chromatographic techniques to achieve ≥95% purity. The primary method for purity verification is SDS-PAGE, while high-performance liquid chromatography (HPLC) is used as a complementary technique. Analytical verification also commonly includes mass spectrometry (MS) to confirm the molecular identity and structural integrity. The final product is lyophilized to improve stability and ease of storage.

What is Follistatin 344 (95%) (1mg) being studied for? What are its possible benefits?

Follistatin 344 (95%) (1mg) has been studied in research models focused on growth factor regulation, particularly involving activins and related signaling proteins. Investigations have explored its potential role in:

• Muscle development and regeneration
• Myostatin signaling
• Endocrine system regulation
• Reproductive biology
• Cell proliferation and differentiation

In experimental settings, Follistatin 344 has been investigated for its ability to bind and neutralize activin-family proteins, which play important roles in cellular growth and differentiation. Potential biological effects observed in laboratory studies remain investigational and are not indicative of clinical efficacy.

How does Follistatin 344 (95%) (1mg) work in research studies?

In laboratory models, Follistatin 344 (95%) (1mg) functions as a binding protein that interacts with activins and other members of the transforming growth factor-beta (TGF-β) superfamily. By binding to these signaling molecules, it may modulate downstream cellular pathways. In simplified terms, Follistatin 344 acts as a regulatory protein that influences the availability of growth factors in experimental systems. This modulation has been studied in contexts such as muscle cell differentiation, tissue remodeling, and endocrine regulation. These mechanisms are still under investigation and are limited to controlled research environments.

What dosing information exists for Follistatin 344 (95%) (1mg)?

Preclinical research involving Follistatin 344 has primarily been conducted in animal and cell culture models. In murine studies, recombinant follistatin proteins have been dosed at microgram per kilogram (µg/kg) ranges, depending on the study’s objectives. In vitro investigations typically use concentrations ranging from nanogram to microgram per milliliter (ng/mL to µg/mL) to evaluate effects on cell proliferation or differentiation. Dosing parameters vary depending on study design. There are no established human dosing guidelines for Follistatin 344 (95%) (1mg), as it is intended solely for laboratory research.

How should Follistatin 344 (95%) (1mg) be stored and handled?

Follistatin 344 (95%) (1mg) should be stored at 2–8 °C for routine laboratory handling. For long-term storage, ≤–20 °C is recommended. Protect the vial from light exposure and excessive moisture. After reconstitution with sterile laboratory-grade solvent, short-term storage at 2–8 °C is advised. Avoid repeated freeze-thaw cycles, as these may affect protein stability. The approximate shelf life is 24 months when stored under the recommended conditions. Standard laboratory protective equipment should be used during handling, and disposal should follow institutional biosafety guidelines.

Where can I read more research about Follistatin 344 (95%) (1mg)?

The following peer-reviewed sources provide background information on follistatin research:

1. Datta-Mannan A, Yaden B, Krishnan V, Jones BE, Croy JE. An engineered human follistatin variant: insights into the pharmacokinetic and pharmocodynamic relationships of a novel molecule with broad therapeutic potential. J Pharmacol Exp Ther. 2013;344(3):616-623. doi:10.1124/jpet.112.201491
2. Castonguay R, Lachey J, Wallner S, et al. Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. J Pharmacol Exp Ther. 2019;368(3):435-445. doi:10.1124/jpet.118.252304
3. Datta-Mannan A, Huang L, Pereira J, Yaden B, Korytko A, Croy JE. Insights into the Impact of Heterogeneous Glycosylation on the Pharmacokinetic Behavior of Follistatin-Fc-Based Biotherapeutics. Drug Metab Dispos. 2015;43(12):1882-1890. doi:10.1124/dmd.115.064519
4. Sugino H, Sugino K, Hashimoto O, Shoji H, Nakamura T. Follistatin and its role as an activin-binding protein. J Med Invest. 1997;44(1-2):1-14.

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.