MOTs-C 20mg

What is MOTs-C (20mg)?

MOTs-C (20mg) is a synthetic research peptide derived from a mitochondria-encoded open reading frame within mitochondrial DNA. It belongs to a class of molecules known as mitochondria-derived peptides (MDPs), which are small signaling peptides produced by mitochondria and studied for their involvement in cellular metabolism and stress response pathways.

• Chemical Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
• Molecular Weight: 2174.64 g/mol
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

In laboratory environments, MOTs-C (20mg) has been studied for its potential role in metabolic signaling, cellular energy regulation, and mitochondrial communication with the nucleus. Research-grade peptide material is typically synthesized to high purity levels and supplied as a lyophilized compound for experimental research applications.

What are the key features of MOTs-C (20mg)?

• Synthetic 16–amino acid mitochondrial peptide
• Supplied as 20 mg lyophilized peptide in sealed research vial
• High research-grade purity verified through analytical testing
• Studied in cellular metabolism and mitochondrial signaling research
• Shelf life of approximately 24 months when stored properly
• For laboratory research use only

How is MOTs-C (20mg) synthesized?

MOTs-C (20mg) is typically produced using solid-phase peptide synthesis (SPPS), a widely used method for constructing peptides with precise amino acid sequences. This process allows researchers to replicate the 16-amino acid sequence of MOTs-C, a mitochondrial-derived peptide encoded by a short open reading frame within the MT-RNR1 (12S rRNA) gene. After synthesis, the peptide is purified by high-performance liquid chromatography (HPLC) to ensure high purity. Analytical verification of molecular identity and mass is performed using mass spectrometry (MS). The purified peptide is then lyophilized to improve stability, making it suitable for storage and transport in research laboratories.

What is MOTs-C (20mg) being studied for? What are its possible benefits?

In research settings, MOTs-C (20mg) has been studied for its role in mitochondrial signaling and cellular metabolic regulation. As a mitochondria-derived peptide, it is being studied in models that explore communication between mitochondria and the cell nucleus. Research areas involving MOTs-C include:

• Metabolic regulation research
• Mitochondrial signaling pathways
• Cellular stress response mechanisms
• Glucose and energy metabolism studies
• Age-related metabolic research models

Laboratory findings suggest MOTs-C may influence metabolic gene expression and cellular energy balance in experimental models. These observations remain investigational and are limited to controlled laboratory research.

How does MOTs-C (20mg) work in research studies?

In laboratory studies, MOTs-C (20mg) is believed to function as a signaling peptide involved in cellular responses to metabolic stress. Unlike many signaling peptides encoded by nuclear DNA, MOTs-C originates from mitochondrial genetic sequences and may influence metabolic regulation. Experimental models suggest that MOTs-C can interact with cellular pathways associated with energy sensing and metabolic adaptation. In research settings, the peptide has been studied for its potential ability to affect cellular responses during metabolic stress conditions, including those related to glucose metabolism and mitochondrial function. These mechanisms are still under investigation and remain limited to experimental systems.

What dosing information exists for MOTs-C (20mg)?

Most dosing data for MOTs-C (20mg) originate from preclinical studies involving cell cultures and animal models. In vitro studies typically examine the peptide at nanomolar to micromolar concentrations to evaluate its effects on cellular metabolic activity. Animal studies have reported experimental dosing ranges in the microgram per kilogram (µg/kg) range, depending on the research design and biological model used. Dosing schedules vary widely across experimental protocols. There are no established human dosing guidelines, as MOTs-C is a research compound intended for laboratory research use only.

How should MOTs-C (20mg) be stored and handled?

MOTs-C (20mg) should be stored under controlled laboratory conditions to maintain stability. Recommended storage conditions include 2–8 °C for standard handling and ≤–20 °C for long-term storage. The lyophilized peptide should be protected from light, moisture, and excessive heat. After reconstitution with sterile laboratory solvent, solutions should generally be stored at 2–8 °C for short-term use. Repeated freeze–thaw cycles should be avoided to maintain peptide integrity. When stored under recommended conditions, MOTs-C typically maintains stability for approximately 24 months. Standard laboratory protective equipment should be used during handling, and disposal should follow institutional biosafety procedures.

Where can I read more research about MOTs-C (20mg)?

1. Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023;14:1120533. Published 2023 Jan 25. doi:10.3389/fendo.2023.1120533
2. Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022;23(19):11991. Published 2022 Oct 9. doi:10.3390/ijms231911991
3. Wan W, Zhang L, Lin Y, et al. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. J Transl Med. 2023;21(1):36. Published 2023 Jan 20. doi:10.1186/s12967-023-03885-2

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.