SS-31 15mg

What is SS-31 (15mg)?

SS-31 (15mg), also known as Elamipretide or MTP-131, is a synthetic tetrapeptide designed for laboratory research. It belongs to a class of compounds that interact with mitochondrial membranes.

• Chemical Formula: C₃₂H₄₉N₉O₅
• Molecular Weight: 639.8 g/mol
• CAS Number: 736992-21-5
• Sequence: D-Arg-dimethyl-Tyr-Lys-Phe-NH₂

SS-31 is manufactured with high purity, as verified by analytical testing such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS). It is studied for its potential interactions with mitochondrial structures involved in cellular energy metabolism.

What are the key features of SS-31 (15mg)?

• Synthetic tetrapeptide composed of four amino acids
• High research-grade purity verified through HPLC and mass spectrometry
• Supplied as 15 mg lyophilized peptide in a sealed research vial
• Studied in mitochondrial signaling and cellular energy metabolism research
• For laboratory research use only

How is SS-31 (15mg) synthesized?

SS-31 (15mg) is synthesized by solid-phase peptide synthesis (SPPS), a standard technique that enables precise assembly of peptide chains. Each amino acid is sequentially added to a solid support until the complete tetrapeptide structure is formed. After synthesis, the peptide is purified using high-performance liquid chromatography (HPLC) to ensure high purity. The peptide’s molecular identity and structural integrity are verified using mass spectrometry (MS). The final peptide is lyophilized to improve stability during storage and transport.

What is SS-31 (15mg) being studied for? What are its possible benefits?

SS-31 (15mg) has been studied for its potential role in mitochondrial biology and cellular energy regulation. Mitochondria produce cellular energy through oxidative phosphorylation, so compounds that influence mitochondrial function are valuable in metabolism research. Research areas involving SS-31 include:

• Mitochondrial function research
• Cellular energy metabolism studies
• Oxidative stress and mitochondrial signaling models
• Cardiovascular and muscle tissue experimental models
• Age-related cellular metabolism investigations

Laboratory findings suggest that peptides targeting mitochondria may modulate cellular signaling pathways involved in oxidative balance and energy production. These potential biological effects are still being studied and should not be considered confirmed therapeutic outcomes.

How does SS-31 (15mg) work in research studies?

In research models, SS-31 (15mg) has been studied for its potential interaction with mitochondrial membranes, particularly with lipid components such as cardiolipin, which are crucial for maintaining mitochondrial structure and function. By associating with mitochondrial membranes, SS-31 may influence processes involved in cellular energy production and oxidative stress regulation. Researchers are studying how this interaction may affect mitochondrial stability and signaling pathways involved in cellular metabolism. These mechanisms are still under investigation in laboratory studies and have not been established as clinical outcomes.

What dosing information exists for SS-31 (15mg)?

Research involving SS-31 (15mg) has primarily been conducted in preclinical studies using cell cultures and animal models. In vitro research typically evaluates peptide activity at nanomolar to micromolar concentrations to examine mitochondrial responses. In animal research, dosing parameters vary by experimental model and study design. Because SS-31 is a research compound, no standardized human dosing guidelines exist, and its use is limited to laboratory research settings.

How should SS-31 (15mg) be stored and handled?

• Store under temperature-controlled conditions per laboratory protocol and certificate of analysis.
• For extended storage, follow temperature conditions specified in the product certificate of analysis.
• Protect the lyophilized peptide from light, heat, and moisture.
• Room-temperature exposure during transport is acceptable for short periods.
• Once reconstituted, store under appropriate temperature-controlled conditions per laboratory protocol for short-term use.
• Avoid repeated freeze-thaw cycles to preserve peptide integrity.
• Refer to the batch certificate of analysis for batch-specific stability data.

Where can I read more research about SS-31 (15mg)?

Researchers interested in SS-31 and mitochondrial peptide research may consult the following publications:

1. Zhu Y, Luo M, Bai X, et al. SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease. Oxid Med Cell Longev. 2022;2022:1295509. Published 2022 Jun 6. doi:10.1155/2022/1295509
2. Du X, Zeng Q, Luo Y, et al. Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction. Mitochondrion. 2024;75:101846. doi:10.1016/j.mito.2024.101846
3. Russo S, De Rasmo D, Signorile A, Corcelli A, Lobasso S. Beneficial effects of SS-31 peptide on cardiac mitochondrial dysfunction in tafazzin knockdown mice. Sci Rep. 2022;12(1):19847. Published 2022 Nov 18. doi:10.1038/s41598-022-24231-4
4. Russo S, De Rasmo D, Rossi R, Signorile A, Lobasso S. SS-31 treatment ameliorates cardiac mitochondrial morphology and defective mitophagy in a murine model of Barth syndrome. Sci Rep. 2024;14(1):13655. Published 2024 Jun 13. doi:10.1038/s41598-024-64368-y
5. Li M, Kong D, Meng L, Wang Z, Bai Z, Wu G. Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis. RSC Adv. 2024;14(41):29789-29799. Published 2024 Sep 18. doi:10.1039/d4ra05517a

Compliance Statement

This product is intended for laboratory research use only and is not approved for human or veterinary use.