Lanluma Protocol and Administration Technique for Practitioners

Poly-L-lactic acid (PLLA) injectables are a key principle in aesthetic medicine, making structured dosing protocols essential for achieving safe and predictable outcomes. Patients who adhered to a planned schedule—receiving injections at baseline, 3 months, and 6 months—experienced superior results with minimal adverse events. These findings emphasize that precise dosing and refined administration techniques are critical for maximizing treatment efficacy.

Building on this foundation, Lanluma, a next-generation PLLA-based collagen stimulator, offers practitioners a robust tool for long-term volumization and contour enhancement. Its success, however, is highly dependent on meticulous preparation, injection accuracy, and adherence to its specific protocol—factors that directly influence both aesthetic outcomes and patient satisfaction.

This article will serve as a practical guide for practitioners, detailing the Lanluma protocol, including preparation methods, administration techniques, dosing strategies, and post-treatment care. By mastering these best practices, clinicians can ensure safe, effective, and natural-looking results for their patients.

Key Takeaways

• Lanluma is a poly-L-lactic acid (PLLA) collagen stimulator that requires precise reconstitution, injection technique, and aftercare for optimal results in facial and body treatments.
• Reconstitution involves mixing 40–60 mL of sterile water per vial, hydrating for at least 12 hours (up to 72 for best consistency), with gentle mixing to avoid foaming and ensure even particle suspension.
• Injection techniques vary by area, using cannulas for safety and even distribution. Facial treatments target the deep dermis or subcutaneous layer, while body treatments focus on the deep subcutaneous plane, avoiding muscle.
• A structured treatment plan typically involves 2 to 3 sessions for the face and 2 to 4 sessions for body areas, spaced 4 to 6 weeks apart, with full results developing over 3 to 6 months and lasting up to two years.
• Post-treatment aftercare, including the 5-5-5 massage rule, is crucial to ensure product integration, prevent nodule formation, and support collagen synthesis.
• Providing clear aftercare instructions and scheduling follow-ups enhances patient satisfaction, reduces complications, and ensures the success of Lanluma treatments.
• Mastery of the Lanluma protocol, from preparation to aftercare, enables practitioners to deliver safe, natural-looking, and long-lasting aesthetic results through regenerative collagen stimulation.

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Lanluma Preparation: Reconstitution Guidelines and Product Handling

Proper reconstitution of Lanluma is a critical first step in ensuring the treatment’s success. Activating its biostimulatory effects depends on meticulous preparation, as improper handling can compromise product integrity and patient outcomes. The reconstitution process varies slightly between Lanluma V (designed for facial applications) and Lanluma X (formulated for body contouring), but the foundational principles remain the same.

Key Reconstitution Steps

• Use 40–60 mL of sterile water for injection (SWFI) per vial, adjusting volume based on treatment area and desired consistency.
• Hydrate the lyophilized powder for a minimum of 12 hours, though allowing up to 72 hours yields superior particle dispersion and smoother injectability.
• Gently swirl or vortex the vial to achieve homogeneity; avoid vigorous shaking, which can introduce unwanted air bubbles and foaming.
• Store the reconstituted product at room temperature and use it within 72 hours to maintain sterility and efficacy.

Practitioners should clearly label vials with reconstitution times and ensure aseptic technique is followed throughout. A well-prepared Lanluma suspension facilitates even distribution during injection, reduces patient discomfort, and minimizes the risk of post-procedural complications such as clumping or nodule formation.

Injection Techniques for Lanluma Administration

Administering Lanluma requires precision and a thorough understanding of anatomical planes to stimulate collagen production effectively while safeguarding patient safety. The choice between blunt-tip cannulas and needles depends on the treatment zone, desired depth, and practitioner preference, always prioritizing patient comfort and procedural control.

Injection Area	Technique Details
Facial Injections (Lanluma V)	Inject into the deep dermis or subcutaneous planeUse linear threading, cross-hatching, or fanning for even distributionEmploy a cannula (25G–27G) for precision and less trauma
Body Injections (Lanluma X)	Inject into the deep subcutaneous layer, avoiding muscleUse a longer cannula (22G–25G) for broad coverageTarget areas include the buttocks, thighs, hips, and upper arms

Regardless of the area, practitioners must always perform aspiration when using needles to mitigate the risk of intravascular injection. Following the injection, an immediate post-treatment massage is essential to aid product integration and prevent particle clumping. Controlled, deliberate injection technique combined with thorough post-injection massage directly impacts treatment success.

Lanluma Treatment Protocol: Timing and Session Frequency

Because Lanluma functions as a collagen biostimulator, its aesthetic improvements unfold gradually. Unlike hyaluronic acid fillers that deliver instant volume, Lanluma’s regenerative process requires a structured treatment plan and patient education to set proper expectations.

Most patients benefit from 2 to 3 sessions for facial rejuvenation and 2 to 4 sessions for body contouring. Initial visible changes typically emerge 6–8 weeks after the first session, with full results manifesting over 3 to 6 months. The longevity of these improvements often extends up to two years, depending on individual factors.

Understanding what is Lanluma is vital for both practitioner success and patient satisfaction. Factors such as age, skin laxity, lifestyle, and treatment goals influence the number of vials required and the frequency of sessions. Open communication about the gradual nature of results helps manage expectations and fosters a more collaborative treatment journey.

Post-Treatment Aftercare and Patient Education

Aftercare is a critical component of the Lanluma protocol, playing a direct role in the quality and longevity of results. One of the most important aftercare practices is the 5-5-5 massage rule:

• 5 minutes of massage
• 5 times a day
• For 5 consecutive days

This self-massage aids in even particle distribution, promotes collagen formation, and reduces the likelihood of nodule development.

Other Aftercare Tips

• Avoid alcohol and strenuous exercise for at least 24 hours post-treatment to reduce inflammation.
• Steer clear of saunas, steam rooms, and direct sun exposure for a minimum of 3 days to allow proper tissue healing.
• Mild bruising, swelling, or tenderness is normal and usually resolves within a few days; gentle cooling may be advised if needed.
• Incorporating a moisturizing lotion during massage can enhance comfort and improve skin hydration during recovery.

Practitioners should provide clear, written aftercare instructions and schedule a follow-up appointment to monitor results and address any concerns. Comprehensive aftercare guidance ensures patients are well-prepared, ultimately maximizing the treatment’s regenerative potential and overall satisfaction.

Conclusion

When meticulously prepared and skillfully administered, the Lanluma protocol offers a safe, effective, and scientifically-backed solution for facial rejuvenation and body contouring. Its unique mechanism of stimulating the body’s own collagen production delivers subtle, natural enhancements that evolve over time, aligning with modern aesthetic preferences for longevity and minimal invasiveness.

Each phase of treatment—from reconstitution to injection techniques to post-care protocols—requires precision and attention to detail. Practitioners who fully understand and respect these nuances can achieve superior outcomes, enhancing both clinical success and patient confidence. Mastery of Lanluma’s protocol is not merely a technical skill but a commitment to delivering high-quality, regenerative aesthetic results.

FAQs

1. How long do Lanluma results last?

Lanluma results typically last up to two years. Maintenance sessions may be scheduled every 18–24 months, depending on the treatment area and individual factors.

2. Is Lanluma suitable for all patients?

Lanluma is suitable for healthy adults with no active infections, autoimmune conditions affecting collagen, or known allergies to PLLA. It is not recommended for pregnant or breastfeeding individuals.

3. Can Lanluma be combined with other treatments?

Yes. Lanluma can complement treatments like hyaluronic acid fillers or skin tightening procedures. However, it should be administered in separate sessions and areas to avoid interference.

4. What if a patient skips the post-treatment massage?

Failure to follow massage instructions can lead to uneven product distribution or small lumps. Reinforce the importance of aftercare during the consultation and provide reminders post-procedure.

References

Amselem M, Fatsea D, Forte R, Hasenöhrl C, Haus A, Salaabian A. Safety and effectiveness results of an innovative injectable poly‐L‐lactic acid‐based collagen stimulator (Lanluma®)—Clinical outcomes at 9 months in a post‐market study. Journal of Cosmetic Dermatology. Published online September 4, 2024. doi:10.1111/jocd.16527

Wu L, Salti G. Combined Forehead and Temporal Lifting: An Innovative Approach to Lanluma V Treatment. J Cosmet Dermatol. 2025;24(1):e16583. doi:10.1111/jocd.16583

Sickles CK, Nassereddin A, Patel P, Gross GP. Poly-L-Lactic acid. StatPearls – NCBI Bookshelf. Published February 28, 2024. https://www.ncbi.nlm.nih.gov/books/NBK507871/